Elliot Imler
@elliotimler.bsky.social
Science person and prankster of great renown. Retired professional dragonfly catcher.
Reposted by Elliot Imler
🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...
Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq
Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue deg...
www.biorxiv.org
March 21, 2025 at 4:17 AM
🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...
Reposted by Elliot Imler
I like that after people discovered neurotransmitters, they effortlessly switched the language of 4 humours theory to be more modern
It sounds more scientific to say "oh no I have too little dopamine" just like 2,400 years ago it sounded more scientific to say "oh no I have too much yellow bile"
It sounds more scientific to say "oh no I have too little dopamine" just like 2,400 years ago it sounded more scientific to say "oh no I have too much yellow bile"
September 6, 2024 at 12:22 AM
I like that after people discovered neurotransmitters, they effortlessly switched the language of 4 humours theory to be more modern
It sounds more scientific to say "oh no I have too little dopamine" just like 2,400 years ago it sounded more scientific to say "oh no I have too much yellow bile"
It sounds more scientific to say "oh no I have too little dopamine" just like 2,400 years ago it sounded more scientific to say "oh no I have too much yellow bile"