Irene Gallego Romero
@ee-reh-neh.bsky.social
Same content, different website! Human evolutionary genomics, functional genomics and archaic hominins. Group leader in Human Genomics at SVI in Melbourne/Naarm, Australia. Durian evangelist. Sometimes I go to Estonia.
Pinned
Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans https://www.biorxiv.org/content/10.1101/2025.05.04.652069v1
🎉 This paper has been a long time and a labour of love (and hardship) for multiple group members, but, finally: we MPRA'ed 25k introgressed variants (Denisovan and Neanderthal) segregating at allele frequencies > 0.15 in humans today to evaluate their potential to regulate gene expression.
Ducks at Carlton Gardens this afternoon. Looks longitudinal but it's cross sectional 😅
November 13, 2025 at 9:25 AM
Ducks at Carlton Gardens this afternoon. Looks longitudinal but it's cross sectional 😅
Reposted by Irene Gallego Romero
After two talks today, a well earned treat!
November 8, 2025 at 11:04 AM
After two talks today, a well earned treat!
Mountains of Java; tea in Jakarta
November 5, 2025 at 7:37 AM
Mountains of Java; tea in Jakarta
Sitting in a hotel terrace in Jakarta and thinking about the (cultural? historical? accidental?) convergence in the flavours of the Colombian hot chocolate my first year RA made us in college, with cheese at the base, and pisang goreng served traditional style, with flecks of chocolate and cheese.
November 4, 2025 at 1:35 PM
Sitting in a hotel terrace in Jakarta and thinking about the (cultural? historical? accidental?) convergence in the flavours of the Colombian hot chocolate my first year RA made us in college, with cheese at the base, and pisang goreng served traditional style, with flecks of chocolate and cheese.
Reposted by Irene Gallego Romero
1/5
🦖 Michael Crichton’s Jurassic Park (1990) turns 35 in November. In a new preprint, I argue that it was a prescient meditation on evolutionary genetics, complexity, & control. I also examine analogous efforts of today (e.g. “de-extinction.")
Select points below:
ecoevorxiv.org/repository/v...
🦖 Michael Crichton’s Jurassic Park (1990) turns 35 in November. In a new preprint, I argue that it was a prescient meditation on evolutionary genetics, complexity, & control. I also examine analogous efforts of today (e.g. “de-extinction.")
Select points below:
ecoevorxiv.org/repository/v...
October 14, 2025 at 12:49 PM
1/5
🦖 Michael Crichton’s Jurassic Park (1990) turns 35 in November. In a new preprint, I argue that it was a prescient meditation on evolutionary genetics, complexity, & control. I also examine analogous efforts of today (e.g. “de-extinction.")
Select points below:
ecoevorxiv.org/repository/v...
🦖 Michael Crichton’s Jurassic Park (1990) turns 35 in November. In a new preprint, I argue that it was a prescient meditation on evolutionary genetics, complexity, & control. I also examine analogous efforts of today (e.g. “de-extinction.")
Select points below:
ecoevorxiv.org/repository/v...
😍🤩😍🤩😍🤩
Why do complex traits differ in their genetic architecture?
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits.
Thread:
journals.plos.org/plosbiology/...
Simple scaling laws control the genetic architectures of human complex traits
Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...
journals.plos.org
October 24, 2025 at 4:55 AM
😍🤩😍🤩😍🤩
Reposted by Irene Gallego Romero
A hearty Denisovan stew ripe with stories of mixing and more mixing, even with a third more ‘archaic’ hominid.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A high-coverage genome from a 200,000-year-old Denisovan
Denisovans, an extinct sister group of Neandertals who lived in Eastern Eurasia during the Middle and Late Pleistocene, are known only from a handful of skeletal remains and limited genetic data, incl...
www.biorxiv.org
October 20, 2025 at 7:07 PM
A hearty Denisovan stew ripe with stories of mixing and more mixing, even with a third more ‘archaic’ hominid.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Irene Gallego Romero
In a new paper led by Jiaqi Yang we trace the distribution of Denisovan introgressed DNA in ancient modern human genomes over time.
www.cell.com/current-biol...
www.cell.com/current-biol...
An early East Asian lineage with unexpectedly low Denisovan ancestry
Yang et al. study Denisovan ancestry in ancient and present-day humans. In contrast
to other East Asians, genomic comparisons suggest that the Jomon derived most of their
ancestry from a deep lineage ...
www.cell.com
October 20, 2025 at 7:39 PM
In a new paper led by Jiaqi Yang we trace the distribution of Denisovan introgressed DNA in ancient modern human genomes over time.
www.cell.com/current-biol...
www.cell.com/current-biol...
Carole was my first boss, and working in her lab an an undergraduate was a fantastic opportunity. So great to see her get this award!!
🎖️Congratulations to the ASHG 2025 Lifetime Achievement Awardee Harry (Hal) Dietz, MD, and Mentorship Awardee Carole Ober, PhD! Learn more about the award and their work here: www.ashg.org/membership/a... #ASHG25
October 16, 2025 at 1:13 AM
Carole was my first boss, and working in her lab an an undergraduate was a fantastic opportunity. So great to see her get this award!!
New, from @navya-shukla.bsky.social and me:
You have a new genome and want to test it for acceleration against other genomes:
Tired: add it to an existing WGA with much toil and tears
Wired: use our new approach to only add conserved regions!
🧬🧪🖥️
You have a new genome and want to test it for acceleration against other genomes:
Tired: add it to an existing WGA with much toil and tears
Wired: use our new approach to only add conserved regions!
🧬🧪🖥️
Lift&Add - rapid and robust addition of new species to alignments of conserved non-coding sequences https://www.biorxiv.org/content/10.1101/2025.10.14.682260v1
October 15, 2025 at 9:43 PM
New, from @navya-shukla.bsky.social and me:
You have a new genome and want to test it for acceleration against other genomes:
Tired: add it to an existing WGA with much toil and tears
Wired: use our new approach to only add conserved regions!
🧬🧪🖥️
You have a new genome and want to test it for acceleration against other genomes:
Tired: add it to an existing WGA with much toil and tears
Wired: use our new approach to only add conserved regions!
🧬🧪🖥️
It's a shameful situation but at least the memes are entertaining
October 13, 2025 at 11:33 AM
It's a shameful situation but at least the memes are entertaining
@jrossibarra.bsky.social maybe this is relevant to your interests?
Agro-STARR-seq enables in planta genome-wide enhancer discovery and AI-empowerd enhancer design https://www.biorxiv.org/content/10.1101/2025.10.10.681754v1
October 12, 2025 at 9:32 AM
@jrossibarra.bsky.social maybe this is relevant to your interests?
Reposted by Irene Gallego Romero
Be sure to check out our monthly Seminar Series!
🔹Upcoming speakers www.varianteffect.org/seminar-seri...
🔹Previous speakers www.varianteffect.org/previous-sem...
#Seminar #Series #Science #FunctionalGenomics
🔹Upcoming speakers www.varianteffect.org/seminar-seri...
🔹Previous speakers www.varianteffect.org/previous-sem...
#Seminar #Series #Science #FunctionalGenomics
October 11, 2025 at 2:16 PM
Be sure to check out our monthly Seminar Series!
🔹Upcoming speakers www.varianteffect.org/seminar-seri...
🔹Previous speakers www.varianteffect.org/previous-sem...
#Seminar #Series #Science #FunctionalGenomics
🔹Upcoming speakers www.varianteffect.org/seminar-seri...
🔹Previous speakers www.varianteffect.org/previous-sem...
#Seminar #Series #Science #FunctionalGenomics
Ikea sending me this portable induction burner as an apology when my stovetop repairs took too long has brought me so much delicious joy.
October 11, 2025 at 9:27 AM
Ikea sending me this portable induction burner as an apology when my stovetop repairs took too long has brought me so much delicious joy.
Reposted by Irene Gallego Romero
Lol the Nobels can't even acknowledge women's contribution to discovery. But sure let's acknowledge The Machines.
October 9, 2025 at 7:00 PM
Lol the Nobels can't even acknowledge women's contribution to discovery. But sure let's acknowledge The Machines.
Move to Australia they said, marsupials are cute and fluffy they said.
October 7, 2025 at 9:46 PM
Move to Australia they said, marsupials are cute and fluffy they said.
You get one more day to make your voice heard on this, guys! It's a great "National Health and Medical Council" strategy, but there's basically no "Research" in it.
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
October 7, 2025 at 1:48 AM
You get one more day to make your voice heard on this, guys! It's a great "National Health and Medical Council" strategy, but there's basically no "Research" in it.
Reposted by Irene Gallego Romero
This single author paper has to be seen to be believed.... My 'GIF' does it no justice
Chen, M. (2023) ‘Rendering protein structures inside cells at the atomic level with Unreal Engine’, bioRxiv.
doi.org/10.1101/2023...
Chen, M. (2023) ‘Rendering protein structures inside cells at the atomic level with Unreal Engine’, bioRxiv.
doi.org/10.1101/2023...
March 1, 2024 at 5:07 PM
This single author paper has to be seen to be believed.... My 'GIF' does it no justice
Chen, M. (2023) ‘Rendering protein structures inside cells at the atomic level with Unreal Engine’, bioRxiv.
doi.org/10.1101/2023...
Chen, M. (2023) ‘Rendering protein structures inside cells at the atomic level with Unreal Engine’, bioRxiv.
doi.org/10.1101/2023...
I'm stoked to be organising next year's MSS right here in beautiful Melbourne! We know Australia is very far away, and we're working hard to make sure we can support as many ECRs to attend as possible, so please do register and apply for a travel award!
📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
October 2, 2025 at 1:47 AM
I'm stoked to be organising next year's MSS right here in beautiful Melbourne! We know Australia is very far away, and we're working hard to make sure we can support as many ECRs to attend as possible, so please do register and apply for a travel award!
Reposted by Irene Gallego Romero
🔴 ÚLTIMA HORA | Muere la etóloga y primatóloga británica Jane Goodall a los 91 años social.elpais.com/wmfcr4
Muere la etóloga británica Jane Goodall a los 91 años
Revolucionó la ciencia desde los sesenta con sus métodos innovadores y fascinantes descubrimientos sobre los chimpancés salvajes
social.elpais.com
October 1, 2025 at 6:22 PM
🔴 ÚLTIMA HORA | Muere la etóloga y primatóloga británica Jane Goodall a los 91 años social.elpais.com/wmfcr4
Reposted by Irene Gallego Romero
Jane Goodall has died at the age of 91.
In 2020, Goodall spoke with Science Editor-in-Chief H. Holden Thorp for a #ScienceEditorial reflecting on the 60th anniversary of her arrival in Gombe to study wild chimpanzees. Read more: https://scim.ag/472Chb8
In 2020, Goodall spoke with Science Editor-in-Chief H. Holden Thorp for a #ScienceEditorial reflecting on the 60th anniversary of her arrival in Gombe to study wild chimpanzees. Read more: https://scim.ag/472Chb8
October 1, 2025 at 7:13 PM
Jane Goodall has died at the age of 91.
In 2020, Goodall spoke with Science Editor-in-Chief H. Holden Thorp for a #ScienceEditorial reflecting on the 60th anniversary of her arrival in Gombe to study wild chimpanzees. Read more: https://scim.ag/472Chb8
In 2020, Goodall spoke with Science Editor-in-Chief H. Holden Thorp for a #ScienceEditorial reflecting on the 60th anniversary of her arrival in Gombe to study wild chimpanzees. Read more: https://scim.ag/472Chb8
Reposted by Irene Gallego Romero
Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees.
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91
www.nytimes.com
October 1, 2025 at 7:52 PM
Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees.
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
Reposted by Irene Gallego Romero
📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
September 26, 2025 at 1:52 PM
📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
I *really* like the eLife model but it feels like some authors don't know what they were signing up for or how to take advantage of it. If you think my review is shit or unreasonable just stop addressing it and move on! Be free, my dudes! Let reviewer 3 rot in the dust!
October 1, 2025 at 5:02 AM
I *really* like the eLife model but it feels like some authors don't know what they were signing up for or how to take advantage of it. If you think my review is shit or unreasonable just stop addressing it and move on! Be free, my dudes! Let reviewer 3 rot in the dust!