I am so happy to share that our paperis officially published in Cell Genomics! In this paper, we describe TESLA-seq, which combines pooled CRISPR activation with targeted single-cell RNA-seq to map enhancer-gene connections at high sensitivity.

Link to the full story: www.cell.com/cell-genomic...

Shortcomings of silhouette in single-cell integration benchmarking - @uweohler.bsky.social @prauten.bsky.social @mdc-bimsb.bsky.social @mdc-berlin.bsky.social @humboldtuni.bsky.social go.nature.com/4fcQzZr

To evaluate computational models, we rely on trusted benchmark data and metrics

So what if a metrics is widely used… but plain wrong? It means that evaluations in dozens of papers are meaningless.

This has happened in single cell genomics…

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Evaluating something like batch correction requires looking at the data, and picking metrics that capture what you care about. Great work @prauten.bsky.social and @uweohler.bsky.social

I think a lot about what Carl Sagan said in one of his final interviews.