Nature Reviews Gastroenterology & Hepatology, Published online: 17 November 2025; doi:10.1038/s41575-025-01138-9Despite the high incidence and mortality rates of hepatopancreatobiliary cancers in the African continent, epidemiological and clinical data are scarce. This Roadmap article describes the efforts of the Africa HepatoPancreatoBiliary Cancer Consortium to establish cancer registries in the region.

How circular extrachromosomal DNA is inherited during cell division is a puzzle. Key sequences enabling this DNA to journey with chromosomes have been identified.

The mutant IDH1 protein, which is expressed in a large fraction of human gliomas, is shown to be immunogenic; mutant-specific immune responses can be detected in patients with IDH1 mutated gliomas and...

The MUTYH base excision repair protein corrects oxidative DNA damage. Bi-allelic germline MUTYH mutations cause a rare, Mendelian recessive syndrome of colorectal adenomas, duodenal polyps and colorec...

A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies in dividing ...

Tumour-associated blood vessels are abnormal in structure and function, and this can limit immune cell infiltration into tumours and contribute to the immunosuppressive tumour microenvironment. This R...

Chromatin structure is a key determinant of gene expression in eukaryotes, but it has not been possible to define the structure of cis-regulatory elem…

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

Signaling networks may provide greater return for the investment in cancer research.

Nature Reviews Genetics, Published online: 03 November 2025; doi:10.1038/s41576-025-00914-2In this Journal Club, Peter Koo reflects on the 2021 publication of Enformer and its impact on the use of deep learning for modelling the regulatory genome.

The accurate representation of data is essential in science communication, however, colour maps that visually distort data through uneven colour gradients or are unreadable to those with colour vision...

AbstractBackground. Technological advances in sequencing and computation have allowed deep exploration of the molecular basis of diseases. Biological netwo

Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.

Nature Reviews Genetics, Published online: 22 October 2025; doi:10.1038/s41576-025-00905-3Jean Fan recounts a 2015 paper by Martincorena et al. that revealed oncogenic mutations in normal tissues, also highlighting how the latest spatial technologies can now be used to study the spatial contextual impact of these mutations.

Survival analysis often relies on Cox models, assuming both linearity and proportional hazards (PH). This study evaluates machine and deep learning me…