Diego García González
@diegoconcalma.bsky.social
Developmental neurobiologist.
Neurogenesis, neurodevelopmental disorders & evolution.
Group leader in a hotel named IBIS. I'm serious.
Neurogenesis, neurodevelopmental disorders & evolution.
Group leader in a hotel named IBIS. I'm serious.
Reposted by Diego García González
How often have you heard that schizophrenia is “80% genetic”?
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 23, 2025 at 11:49 AM
How often have you heard that schizophrenia is “80% genetic”?
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
Relevant thread II
Today I am starting a weekly post titled "Autism: The Evidence". I hope it helps someone fight the colossal wave of misinformation that is drowning us. Part 1: I heard Autism prevalence has gone up. Is that true? If so why?
November 22, 2025 at 11:23 AM
Relevant thread II
Relevant thread
November 22, 2025 at 11:22 AM
Relevant thread
Reposted by Diego García González
Nature research paper: Rewiring an olfactory circuit by altering cell-surface combinatorial code
go.nature.com/3MbCoZT
go.nature.com/3MbCoZT
Rewiring an olfactory circuit by altering cell-surface combinatorial code - Nature
In Drosophila, changing the expression of a small set of cell-surface proteins in just one type of olfactory neuron rewires its connections almost entirely to a new postsynaptic partner neuron type, altering the fly’s odour response and courtship behaviour.
go.nature.com
November 21, 2025 at 11:12 AM
Nature research paper: Rewiring an olfactory circuit by altering cell-surface combinatorial code
go.nature.com/3MbCoZT
go.nature.com/3MbCoZT
Reposted by Diego García González
Where on earth is the best laboratory to demonstrate the beauty of fluid dynamics?
Actually, it’s not on earth. Here is the story of the soft cell.
And a longer read: www.maths.ox.ac.uk/node/74308
Actually, it’s not on earth. Here is the story of the soft cell.
And a longer read: www.maths.ox.ac.uk/node/74308
November 19, 2025 at 3:40 PM
Where on earth is the best laboratory to demonstrate the beauty of fluid dynamics?
Actually, it’s not on earth. Here is the story of the soft cell.
And a longer read: www.maths.ox.ac.uk/node/74308
Actually, it’s not on earth. Here is the story of the soft cell.
And a longer read: www.maths.ox.ac.uk/node/74308
Reposted by Diego García González
“Among the EU countries, the proportion of female scientists and engineers varied widely in 2023, with the highest shares registered in Denmark (50.8%), Spain (50.0 %,) and Bulgaria (49.1%), Latvia and Ireland (each 49%).”
Fuente: ec.europa.eu/eurostat/web...
Fuente: ec.europa.eu/eurostat/web...
November 15, 2025 at 4:06 PM
“Among the EU countries, the proportion of female scientists and engineers varied widely in 2023, with the highest shares registered in Denmark (50.8%), Spain (50.0 %,) and Bulgaria (49.1%), Latvia and Ireland (each 49%).”
Fuente: ec.europa.eu/eurostat/web...
Fuente: ec.europa.eu/eurostat/web...
Reposted by Diego García González
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Conservation and alteration of mammalian striatal interneurons - Nature
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...
www.nature.com
November 7, 2025 at 6:06 PM
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Reposted by Diego García González
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
November 5, 2025 at 6:53 PM
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
Reposted by Diego García González
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
October 31, 2025 at 8:45 AM
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
Reposted by Diego García González
🤔 Is motile #cilia dysfunction a cause of #hydrocephalus ?
The answer depends on who you ask and which species you study. 🤔😕🧐
In mice, motile cilia dysfunction almost always leads to hydrocephalus. In humans, however, the link is far less clear. So why the difference?
The answer depends on who you ask and which species you study. 🤔😕🧐
In mice, motile cilia dysfunction almost always leads to hydrocephalus. In humans, however, the link is far less clear. So why the difference?
Exploring Ciliary Mechanisms in the Causation of Hydrocephalus in Humans—Similarities and Differences from Animal Models - Journal of Molecular Neuroscience
Hydrocephalus is a condition defined by excessive cerebrospinal fluid (CSF) relative to the brain volume. Congenital and infantile forms of hydrocephalus are both genetically and physiologically heter...
doi.org
October 30, 2025 at 8:43 PM
🤔 Is motile #cilia dysfunction a cause of #hydrocephalus ?
The answer depends on who you ask and which species you study. 🤔😕🧐
In mice, motile cilia dysfunction almost always leads to hydrocephalus. In humans, however, the link is far less clear. So why the difference?
The answer depends on who you ask and which species you study. 🤔😕🧐
In mice, motile cilia dysfunction almost always leads to hydrocephalus. In humans, however, the link is far less clear. So why the difference?
Reposted by Diego García González
More than two decades have passed since we discovered that rare disruptions of the FOXP2 gene disturb development of proficient speech/language skills. Today we know of multiple FOXP genes that are directly implicated in distinct brain-related conditions with differences in symptoms & severity.🧪 1/n
October 29, 2025 at 5:09 PM
More than two decades have passed since we discovered that rare disruptions of the FOXP2 gene disturb development of proficient speech/language skills. Today we know of multiple FOXP genes that are directly implicated in distinct brain-related conditions with differences in symptoms & severity.🧪 1/n
Reposted by Diego García González
Interested in understanding how new cell types evolve? Consider joining our group for a PhD!
2026 PhD recruitment is now open.
As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:
www.crick.ac.uk/careers-stud...
As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:
www.crick.ac.uk/careers-stud...
PhD student recruitment
PhD recruitment information.
www.crick.ac.uk
October 7, 2025 at 4:43 PM
Interested in understanding how new cell types evolve? Consider joining our group for a PhD!
Reposted by Diego García González
RIP John Gurdon
October 7, 2025 at 6:06 PM
RIP John Gurdon
Reposted by Diego García González
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
October 3, 2025 at 7:14 AM
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
Reposted by Diego García González
Reposted by Diego García González
I add that earlier and later diagnosed autism are not valid diagnostic terms and what we are looking at is (one) gradient. Also genetics explains only a fraction of the variance, with most studied factors explaining < 10%. We have FAQs in the Supplementary where we address common questions.
October 1, 2025 at 4:05 PM
I add that earlier and later diagnosed autism are not valid diagnostic terms and what we are looking at is (one) gradient. Also genetics explains only a fraction of the variance, with most studied factors explaining < 10%. We have FAQs in the Supplementary where we address common questions.
Reposted by Diego García González
CORTICAL EVOLUTION - 15-17th June 2026 - Bilbao Spain
Organizers: Verónica Martínez Cerdeño, Fernando García Moreno, Elena Vecino, and Stephen Noctor
Early registration until 1st May 2026
ventricular.org/corticalevol...
@veronicamartinez.bsky.social @phylobrain.bsky.social
Organizers: Verónica Martínez Cerdeño, Fernando García Moreno, Elena Vecino, and Stephen Noctor
Early registration until 1st May 2026
ventricular.org/corticalevol...
@veronicamartinez.bsky.social @phylobrain.bsky.social
September 27, 2025 at 9:12 AM
CORTICAL EVOLUTION - 15-17th June 2026 - Bilbao Spain
Organizers: Verónica Martínez Cerdeño, Fernando García Moreno, Elena Vecino, and Stephen Noctor
Early registration until 1st May 2026
ventricular.org/corticalevol...
@veronicamartinez.bsky.social @phylobrain.bsky.social
Organizers: Verónica Martínez Cerdeño, Fernando García Moreno, Elena Vecino, and Stephen Noctor
Early registration until 1st May 2026
ventricular.org/corticalevol...
@veronicamartinez.bsky.social @phylobrain.bsky.social
Reposted by Diego García González
Last days to apply! Cool project, cool cities! :-)
(Please repost! 🙏)
(Please repost! 🙏)
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
September 22, 2025 at 7:04 AM
Last days to apply! Cool project, cool cities! :-)
(Please repost! 🙏)
(Please repost! 🙏)
What a beautiful story, Idoia.
Congratulations!
Congratulations!
🧠🦈Excited to present our latest work🧠🦈Interested in brain evolution? And shark embryos? Then read on… Our work sheds light on the deep origins of our brain’s most complex regions.
September 9, 2025 at 3:53 PM
What a beautiful story, Idoia.
Congratulations!
Congratulations!
Reposted by Diego García González
🦟 Mosquitos invasores
👩🔬👨🔬 El @ceabcsic.bsky.social y @mosquitoalert.bsky.social presentan el primer mapa municipal de la distribución de tres especies invasoras en España: mosquito tigre, de la fiebre amarilla y del Japón
🔎Más de 1.800 municipios han sido colonizados
👉 http://tiny.cc/ia5s001
👩🔬👨🔬 El @ceabcsic.bsky.social y @mosquitoalert.bsky.social presentan el primer mapa municipal de la distribución de tres especies invasoras en España: mosquito tigre, de la fiebre amarilla y del Japón
🔎Más de 1.800 municipios han sido colonizados
👉 http://tiny.cc/ia5s001
September 6, 2025 at 2:01 PM
🦟 Mosquitos invasores
👩🔬👨🔬 El @ceabcsic.bsky.social y @mosquitoalert.bsky.social presentan el primer mapa municipal de la distribución de tres especies invasoras en España: mosquito tigre, de la fiebre amarilla y del Japón
🔎Más de 1.800 municipios han sido colonizados
👉 http://tiny.cc/ia5s001
👩🔬👨🔬 El @ceabcsic.bsky.social y @mosquitoalert.bsky.social presentan el primer mapa municipal de la distribución de tres especies invasoras en España: mosquito tigre, de la fiebre amarilla y del Japón
🔎Más de 1.800 municipios han sido colonizados
👉 http://tiny.cc/ia5s001
Reposted by Diego García González
1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature -
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The evolution of hominin bipedalism in two steps - Nature
The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—...
www.nature.com
August 27, 2025 at 3:13 PM
1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature -
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Diego García González
Lamentamos profundamente el fallecimiento del académico José Manuel García Verdugo, catedrático de la Universitat de Valencia. Referente internacional en Neurocencia y Microscopía Electrónica.
Su última charla en la #raciencias puedes recuperarla aquí: www.youtube.com/live/g7nPBVo...
Su última charla en la #raciencias puedes recuperarla aquí: www.youtube.com/live/g7nPBVo...
July 7, 2025 at 10:20 AM
Lamentamos profundamente el fallecimiento del académico José Manuel García Verdugo, catedrático de la Universitat de Valencia. Referente internacional en Neurocencia y Microscopía Electrónica.
Su última charla en la #raciencias puedes recuperarla aquí: www.youtube.com/live/g7nPBVo...
Su última charla en la #raciencias puedes recuperarla aquí: www.youtube.com/live/g7nPBVo...
Reposted by Diego García González
Incredible diversity of #pollen grains!
Pollen autofluorescence acquired with @zeiss-microscopy.bsky.social #superresolution Airyscan & color-coded for depth
#microscopy #bioimaging #bioart #sciart #botany #plantscience #fluorescencefriday
Pollen autofluorescence acquired with @zeiss-microscopy.bsky.social #superresolution Airyscan & color-coded for depth
#microscopy #bioimaging #bioart #sciart #botany #plantscience #fluorescencefriday
June 27, 2025 at 4:40 PM
Incredible diversity of #pollen grains!
Pollen autofluorescence acquired with @zeiss-microscopy.bsky.social #superresolution Airyscan & color-coded for depth
#microscopy #bioimaging #bioart #sciart #botany #plantscience #fluorescencefriday
Pollen autofluorescence acquired with @zeiss-microscopy.bsky.social #superresolution Airyscan & color-coded for depth
#microscopy #bioimaging #bioart #sciart #botany #plantscience #fluorescencefriday