Mathieu Dedenon
@dedenonmathieu.bsky.social
PostDoc, Kruse lab at UNIGE, working on active living matter and tissue mechanics.
Former PhD at Curie institute on cell & tissue mechanics.
Former PhD at Curie institute on cell & tissue mechanics.
Pinned
Mathieu Dedenon: Three-dimensional formulation of curved nematic shells https://arxiv.org/abs/2510.19412 https://arxiv.org/pdf/2510.19412 https://arxiv.org/html/2510.19412
📢 New preprint !
Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔
I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation !
This was a funny summer project 😊
Please check if you are interested in the comparison between 2d and 3d nematic theories 🤔
I show that the 2d description can lead to artefacts on curved surfaces, and I propose a thin film description of nematic shells with full 3d orientation !
This was a funny summer project 😊
Reposted by Mathieu Dedenon
The law of the jungle.
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
November 21, 2025 at 1:07 PM
The law of the jungle.
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Reposted by Mathieu Dedenon
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
November 23, 2025 at 8:01 AM
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
Reposted by Mathieu Dedenon
Why would Mycobacterium shed its surface right after entering a host cell? Host phagocytes rapidly strip its outer layer, releasing components that alert neighbors and trigger defense responses
Our preprint is out, curious to hear your take! 👀
www.biorxiv.org/content/10.1...
Our preprint is out, curious to hear your take! 👀
www.biorxiv.org/content/10.1...
November 20, 2025 at 2:29 PM
Why would Mycobacterium shed its surface right after entering a host cell? Host phagocytes rapidly strip its outer layer, releasing components that alert neighbors and trigger defense responses
Our preprint is out, curious to hear your take! 👀
www.biorxiv.org/content/10.1...
Our preprint is out, curious to hear your take! 👀
www.biorxiv.org/content/10.1...
Reposted by Mathieu Dedenon
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
November 20, 2025 at 6:11 PM
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
Reposted by Mathieu Dedenon
Gautham Gopinath, Emmanuel Y. Mintah, Aashrith Saraswathibhatla, Jonah J. Spencer, Shahar Nahum, Lior Aria, Jacob Notbohm, Mark D. Shattuck, Corey S. O'Hern: Cell Shape Emerges from Motion https://arxiv.org/abs/2511.14707 https://arxiv.org/pdf/2511.14707 https://arxiv.org/html/2511.14707
November 19, 2025 at 6:43 AM
Gautham Gopinath, Emmanuel Y. Mintah, Aashrith Saraswathibhatla, Jonah J. Spencer, Shahar Nahum, Lior Aria, Jacob Notbohm, Mark D. Shattuck, Corey S. O'Hern: Cell Shape Emerges from Motion https://arxiv.org/abs/2511.14707 https://arxiv.org/pdf/2511.14707 https://arxiv.org/html/2511.14707
Reposted by Mathieu Dedenon
Messal, H. A., Alt, S., Ferreira, R. M., Gribben, C., Wang, V. M. Y., Cotoi, C. G., ... & Behrens, A. (2019). Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature, doi.org/10.1038/s415... #EpithelialMechanics
November 17, 2025 at 8:00 AM
Messal, H. A., Alt, S., Ferreira, R. M., Gribben, C., Wang, V. M. Y., Cotoi, C. G., ... & Behrens, A. (2019). Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature, doi.org/10.1038/s415... #EpithelialMechanics
Reposted by Mathieu Dedenon
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 14, 2025 at 10:35 AM
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Reposted by Mathieu Dedenon
Hi, I’m David Brückner @davidbrueckner.bsky.social.
I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.
buff.ly/RFxVeHh
I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.
buff.ly/RFxVeHh
November 15, 2025 at 8:00 AM
Hi, I’m David Brückner @davidbrueckner.bsky.social.
I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.
buff.ly/RFxVeHh
I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.
buff.ly/RFxVeHh
Reposted by Mathieu Dedenon
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
November 13, 2025 at 8:49 PM
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
Reposted by Mathieu Dedenon
Microfluidic pumping with active nematics! Self-organized and self-sustained. No external pumps.
@pnas.org @ub.edu
www.pnas.org/doi/10.1073/...
#ActiveMatter #Microfluidics #SoftMatter
@pnas.org @ub.edu
www.pnas.org/doi/10.1073/...
#ActiveMatter #Microfluidics #SoftMatter
Active nematic pumps | PNAS
Microfluidics involves the manipulation of flows at the microscale, typically requiring
external power sources to generate pressure gradients. Alte...
www.pnas.org
November 12, 2025 at 7:20 PM
Microfluidic pumping with active nematics! Self-organized and self-sustained. No external pumps.
@pnas.org @ub.edu
www.pnas.org/doi/10.1073/...
#ActiveMatter #Microfluidics #SoftMatter
@pnas.org @ub.edu
www.pnas.org/doi/10.1073/...
#ActiveMatter #Microfluidics #SoftMatter
Reposted by Mathieu Dedenon
Petkova, M. D., Tkačik, G., Bialek, W., Wieschaus, E. F., & Gregor, T. (2019). Optimal decoding of cellular identities in a genetic network. Cell, #EpithelialMechanics doi.org/10.1016/j.ce...
November 13, 2025 at 11:00 AM
Petkova, M. D., Tkačik, G., Bialek, W., Wieschaus, E. F., & Gregor, T. (2019). Optimal decoding of cellular identities in a genetic network. Cell, #EpithelialMechanics doi.org/10.1016/j.ce...
Reposted by Mathieu Dedenon
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...
PNAS www.pnas.org/doi/10.1073/...
November 11, 2025 at 11:01 PM
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...
PNAS www.pnas.org/doi/10.1073/...
Reposted by Mathieu Dedenon
Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
Main - Cell Dynamics and Fragmentation Lab
The Cell Dynamics and Fragmentation lab at We study how single cells move and fragment in complex environments using microfluidics. We bring tools and concep...
celldynamicslab.com
November 11, 2025 at 5:10 PM
Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
Reposted by Mathieu Dedenon
A game changer in our hands... www.nature.com/articles/s41...
Universal consensus 3D segmentation of cells from 2D segmented stacks - Nature Methods
u-Segment3D is a universal framework that translates and enhances 2D instance segmentations to a 3D consensus instance segmentation without training data. It performs well across diverse datasets, inc...
www.nature.com
November 11, 2025 at 6:48 PM
A game changer in our hands... www.nature.com/articles/s41...
Reposted by Mathieu Dedenon
Beussman, K. M., Mollica, M. Y., Leonard, A., Miles, J., Hocter, J., ..., Thomas, W. E., & Sniadecki, N. J. (2023). Black dots: High-yield traction force microscopy reveals structural factors contributing to platelet forces. Acta biomaterialia, 163, 302–311. #EpithelialMechanics
buff.ly/cByoHep
buff.ly/cByoHep
November 7, 2025 at 8:01 AM
Beussman, K. M., Mollica, M. Y., Leonard, A., Miles, J., Hocter, J., ..., Thomas, W. E., & Sniadecki, N. J. (2023). Black dots: High-yield traction force microscopy reveals structural factors contributing to platelet forces. Acta biomaterialia, 163, 302–311. #EpithelialMechanics
buff.ly/cByoHep
buff.ly/cByoHep
Reposted by Mathieu Dedenon
Ever wonder what happens to immune cells when we get a fever? Exicted to share our paper showing that temperature regulates immune cell migration via myosinII! A wonderful collaboration with Ivan, @alempheius.bsky.social, @valeriaventurini.bsky.social & all co-authors!
bit.ly/48XRVGj
bit.ly/48XRVGj
Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses
Effective immune responses rely on the efficient migration of leukocytes. Yet, how temperature regulates migration dynamics at the single-cell level h…
bit.ly
November 4, 2025 at 8:19 PM
Ever wonder what happens to immune cells when we get a fever? Exicted to share our paper showing that temperature regulates immune cell migration via myosinII! A wonderful collaboration with Ivan, @alempheius.bsky.social, @valeriaventurini.bsky.social & all co-authors!
bit.ly/48XRVGj
bit.ly/48XRVGj
Reposted by Mathieu Dedenon
Surface mechanics and compressive stress impact mammalian follicle development
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
Surface mechanics and compressive stress impact mammalian follicle development
Mice were group housed in individually ventilated cages with access to water and food under a 12-h light/12-h dark cycle. Mouse rooms were maintained at 18–25 °C and 30-70% relative humidity. C57BL/6NTac female mice, aged P25 – P28, were euthanized...
www.nature.com
November 2, 2025 at 6:55 AM
Reposted by Mathieu Dedenon
Exciting @centuri-ls.bsky.social internal seminar by @efeilker-phys.bsky.social on energetics and scaling during development 🤩
November 4, 2025 at 8:03 AM
Exciting @centuri-ls.bsky.social internal seminar by @efeilker-phys.bsky.social on energetics and scaling during development 🤩
Reposted by Mathieu Dedenon
Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics?
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
November 2, 2025 at 9:02 AM
Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics?
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
Reposted by Mathieu Dedenon
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
October 31, 2025 at 8:45 AM
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
Reposted by Mathieu Dedenon
Two 2-year postdoc positions in my theory group — for studying the interplay between metabolism and morphogenesis at the edge of the Calanques and the Mediterranean. More information can be found on: euraxess.ec.europa.eu/jobs/381176
#biophysics
#biophysics
Postdoc in Theoretical Biophysics
Two postdoc positions (each for two years, funded by Amidex Foundation) are available in theoretical biophysics within the theory group at DyNaMo (Aix-Marseille University).
euraxess.ec.europa.eu
October 27, 2025 at 4:19 PM
Two 2-year postdoc positions in my theory group — for studying the interplay between metabolism and morphogenesis at the edge of the Calanques and the Mediterranean. More information can be found on: euraxess.ec.europa.eu/jobs/381176
#biophysics
#biophysics
Reposted by Mathieu Dedenon
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
Reposted by Mathieu Dedenon
Too much cell fusion can break your bones, literally!
IPBS researchers @chrisverollet.bsky.social & coll. found that moesin keeps bone-resorbing cells (osteoclasts) in check.
Without it, bones weaken, a discovery that could inspire new #osteoporosis treatments.
📘 @jcb.org shorturl.at/N0Esc
IPBS researchers @chrisverollet.bsky.social & coll. found that moesin keeps bone-resorbing cells (osteoclasts) in check.
Without it, bones weaken, a discovery that could inspire new #osteoporosis treatments.
📘 @jcb.org shorturl.at/N0Esc
Moesin Protein Controls Bone Remodeling by Regulating Osteoclast Fusion and Function - IPBS-Toulouse
Researchers at the Institut de Pharmacologie et Biologie Structurale (IPBS) have uncovered a pivotal role[…]
www.ipbs.fr
October 27, 2025 at 5:17 PM
Too much cell fusion can break your bones, literally!
IPBS researchers @chrisverollet.bsky.social & coll. found that moesin keeps bone-resorbing cells (osteoclasts) in check.
Without it, bones weaken, a discovery that could inspire new #osteoporosis treatments.
📘 @jcb.org shorturl.at/N0Esc
IPBS researchers @chrisverollet.bsky.social & coll. found that moesin keeps bone-resorbing cells (osteoclasts) in check.
Without it, bones weaken, a discovery that could inspire new #osteoporosis treatments.
📘 @jcb.org shorturl.at/N0Esc
Reposted by Mathieu Dedenon
Hot out of press!!!
Studying chloroplast organisation from the perspective of packing problems in confinement.
chloroplasts show multiple configurations for different purposes (optimal light uptake in dim light vs. light avoidance in strong light for photo protection)🌿
www.pnas.org/doi/10.1073/...
Studying chloroplast organisation from the perspective of packing problems in confinement.
chloroplasts show multiple configurations for different purposes (optimal light uptake in dim light vs. light avoidance in strong light for photo protection)🌿
www.pnas.org/doi/10.1073/...
Optimal disk packing of chloroplasts in plant cells | PNAS
Photosynthesis is essential for ecosystem survival, but while plants require light,
excessive exposure can damage cells. Chloroplasts, photosynthet...
www.pnas.org
October 27, 2025 at 8:14 AM
Hot out of press!!!
Studying chloroplast organisation from the perspective of packing problems in confinement.
chloroplasts show multiple configurations for different purposes (optimal light uptake in dim light vs. light avoidance in strong light for photo protection)🌿
www.pnas.org/doi/10.1073/...
Studying chloroplast organisation from the perspective of packing problems in confinement.
chloroplasts show multiple configurations for different purposes (optimal light uptake in dim light vs. light avoidance in strong light for photo protection)🌿
www.pnas.org/doi/10.1073/...
Reposted by Mathieu Dedenon
Join the coolest club on the internet!
#EpithelialMechanics
#EpithelialMechanics
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 3:11 PM
Join the coolest club on the internet!
#EpithelialMechanics
#EpithelialMechanics