David Zhang
@davidzhangmd.bsky.social
Studying genomics, transcriptomics, and all things data science in interstitial lung disease at Columbia University.
Reposted by David Zhang
Calling all centers serving individuals with Telomere Biology Disorders!
Team Telomere is expanding our Centers of Excellence network to advance coordinated, high-quality TBD care, research, and advocacy.
Applications due April 17, 2026 (5PM ET).
Team Telomere is expanding our Centers of Excellence network to advance coordinated, high-quality TBD care, research, and advocacy.
Applications due April 17, 2026 (5PM ET).
February 4, 2026 at 4:01 PM
Calling all centers serving individuals with Telomere Biology Disorders!
Team Telomere is expanding our Centers of Excellence network to advance coordinated, high-quality TBD care, research, and advocacy.
Applications due April 17, 2026 (5PM ET).
Team Telomere is expanding our Centers of Excellence network to advance coordinated, high-quality TBD care, research, and advocacy.
Applications due April 17, 2026 (5PM ET).
Reposted by David Zhang
📊 Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case–control cohorts
🔹 Common and rare genetic variation confer context-specific genetic risk in #IPF, both competitively and cooperatively
🔓 tinyurl.com/ycxxpxf5
🔹 Common and rare genetic variation confer context-specific genetic risk in #IPF, both competitively and cooperatively
🔓 tinyurl.com/ycxxpxf5
January 29, 2026 at 3:23 PM
📊 Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case–control cohorts
🔹 Common and rare genetic variation confer context-specific genetic risk in #IPF, both competitively and cooperatively
🔓 tinyurl.com/ycxxpxf5
🔹 Common and rare genetic variation confer context-specific genetic risk in #IPF, both competitively and cooperatively
🔓 tinyurl.com/ycxxpxf5
Genetic heterogeneity in IPF has been a major gap. In our new paper, we define genetic endotypes of IPF, uncover subtype-specific risk, improve disease prediction, and identify telomere-associated polygenic risk as a key, previously unrecognized driver.
thelancet.com/journals/lan...
thelancet.com/journals/lan...
Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case–control cohorts
Common and rare genetic variation confer context-specific genetic risk in patients
with IPF both competitively and cooperatively. In contrast to known IPF common risk
variants, the telomere length PRS...
thelancet.com
January 28, 2026 at 4:12 PM
Genetic heterogeneity in IPF has been a major gap. In our new paper, we define genetic endotypes of IPF, uncover subtype-specific risk, improve disease prediction, and identify telomere-associated polygenic risk as a key, previously unrecognized driver.
thelancet.com/journals/lan...
thelancet.com/journals/lan...
Reposted by David Zhang
Age-dependent Genetic Risk in Pulmonary Fibrosis Patients and Relatives https://www.medrxiv.org/content/10.64898/2026.01.07.25342496v1
January 15, 2026 at 3:12 PM
Age-dependent Genetic Risk in Pulmonary Fibrosis Patients and Relatives https://www.medrxiv.org/content/10.64898/2026.01.07.25342496v1
I’m delighted to partner with Uplifting Athletes and @teamtelomere.bsky.social! This grant will enable new research to support the 1 in 10 Americans diagnosed with a #RareDisease. Join me as #WeTackleRare at the Young Investigator Draft on Jan. 31! #YID26 bit.ly/yid2026
@columbiamed.bsky.social
@columbiamed.bsky.social
Support Young Investigator Draft 2026
We are thrilled to announce that the Young Investigator Draft will be held at the Lincoln Financial Field in Philadelphia on January 31, 2026. This is a one-of-a-kind evening, honoring incredible rare...
bit.ly
December 18, 2025 at 3:18 PM
I’m delighted to partner with Uplifting Athletes and @teamtelomere.bsky.social! This grant will enable new research to support the 1 in 10 Americans diagnosed with a #RareDisease. Join me as #WeTackleRare at the Young Investigator Draft on Jan. 31! #YID26 bit.ly/yid2026
@columbiamed.bsky.social
@columbiamed.bsky.social
Reposted by David Zhang
Genetic Associations in Non-Europeans with Pulmonary Fibrosis: Analysis of the All of Us Cohort
Key genetic risk factors of IPF are less prevalent in non-European individuals but confer similar risk of disease when present
@davidzhangmd.bsky.social
#medsky
🔗 tinyurl.com/2w8jpj9r
Key genetic risk factors of IPF are less prevalent in non-European individuals but confer similar risk of disease when present
@davidzhangmd.bsky.social
#medsky
🔗 tinyurl.com/2w8jpj9r
October 20, 2025 at 6:09 PM
Genetic Associations in Non-Europeans with Pulmonary Fibrosis: Analysis of the All of Us Cohort
Key genetic risk factors of IPF are less prevalent in non-European individuals but confer similar risk of disease when present
@davidzhangmd.bsky.social
#medsky
🔗 tinyurl.com/2w8jpj9r
Key genetic risk factors of IPF are less prevalent in non-European individuals but confer similar risk of disease when present
@davidzhangmd.bsky.social
#medsky
🔗 tinyurl.com/2w8jpj9r
Reposted by David Zhang
This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
September 25, 2025 at 8:13 PM
This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
Reposted by David Zhang
Delighted to share our new study evaluating the association of rare variants in telomere and non-telomere monogenic adult-onset Pulmonary Fibrosis genes and IPF patient survival where we also intersected their effects with #PRS of IPF.
🧬 Rare variants and survival of patients with idiopathic pulmonary fibrosis: analysis of a multicentre, observational cohort study with independent validation
📈 Non-additive effects were seen between qualifying variants and common risk variants in #IPF survival
🔗 www.thelancet.com/journals/lan...
📈 Non-additive effects were seen between qualifying variants and common risk variants in #IPF survival
🔗 www.thelancet.com/journals/lan...
April 29, 2025 at 8:42 AM
Delighted to share our new study evaluating the association of rare variants in telomere and non-telomere monogenic adult-onset Pulmonary Fibrosis genes and IPF patient survival where we also intersected their effects with #PRS of IPF.