He mentally 1-2 days feels better though I recognize it is not logicalLu optimal to have that delay

This comment is evergreen

Even discounting Kelly's future cash flows at 5-6%, the present value of his contract is ~$45mm, meaning he leaves $20mm on the table by taking the $25mm deal.

But LSU apparently offered to cut out his "duty to mitigate" clause, which allows LSU to offset payments against Kelly's future earnings.

Please find our comment describing concerns about this review:

www.cochranelibrary.com/cdsr/doi/10....

@mikejohansenmd.medsky.social @hswapnil.medsky.social @rnflex.bsky.social

May I ask: Reports from whom? Do you have a reference? I have not seen reporting to this effect.

@mikejohansenmd.medsky.social The fatal flaw is they pre-specified a clinically relevant absolute risk threshold without considering time horizon or base rate.

The base rate in these trials of <1 year was 0.5%, which is less than the 1% absolute risk reduction they said was clinically significant.

This RRR is even greater than that for high-intensity statins in meta analyses!

I think in the present era Cochrane probably does more harm than good.

The test characteristics for screening for CKD are very different than for the diseases you mention. The benefits of treatment also different.

The pediatric world is different but I am not convinced of this idea:

bsky.app/profile/rhea...

Screening is seductive especially to specialists who see the impact of these terrible diseases. But unfortunately screening often is not as effective as we would hope.

Weird. The pdf shows the abstract version not the pubmed version.

The other thing is that the methods of the per protocol analyses are summarized in one paragraph without much detail. No mention in supplement. These analyses are not trivial (including simulation!), like another full paper. I would like to see what assumptions and methods are being used here.

This is what I see

At a BMJ family journal, we had a manuscript repeatedly bounced back because the submission system did not auto detect all of the authors on a long author list. So they requested submit cumbersome form to “change authors”, signed by all authors, even though the manuscript shows no such change made.

Journals are increasingly offshoring or AI-ing the gate keeping “quality control” functions before an editor even sees the manuscript.

It is so incredibly frustrating to get one’s manuscript bounced back for totally ridiculous and trivial issues. And it is impossible to get the journals to budge

She was a truly remarkable person... her intellect, empathy, and moral clarity. No one else like her. Happy b-day Shekinah.

@minnajohansson.bsky.social Thanks for writing this paper. Too many people overstate the benefit and understate the opportunity costs of promoting of individual behavior change in primary care.

Hey Mike did you listen to this terrific Annals podcast with Minna Johannson that touches on this topic?

www.acpjournals.org/doi/10.7326/...