Dandan Peng
@dandanpeng.bsky.social
Ph.D. student @Edge lab in USC
Reposted by Dandan Peng
Ferrari @jazlynmooney.bsky.social et al. find that while parameter scaling improves efficiency, strong scaling distorts diversity, intensifies background selection, and alters linkage patterns.
🔗 doi.org/10.1093/gbe/evaf097
#genome #evolution #bioinformatics
🔗 doi.org/10.1093/gbe/evaf097
#genome #evolution #bioinformatics
Parameter Scaling in Population Genetics Simulations may Introduce Unintended Background Selection: Considerations for Scaled Simulation Design
Abstract. Scaling is a common practice in population genetic simulations to increase computational efficiency. However, few studies systematically examine
doi.org
June 11, 2025 at 9:44 AM
Ferrari @jazlynmooney.bsky.social et al. find that while parameter scaling improves efficiency, strong scaling distorts diversity, intensifies background selection, and alters linkage patterns.
🔗 doi.org/10.1093/gbe/evaf097
#genome #evolution #bioinformatics
🔗 doi.org/10.1093/gbe/evaf097
#genome #evolution #bioinformatics
Reposted by Dandan Peng
a quick note on my paper with @jeffspence.bsky.social and @jkpritch.bsky.social on conditional frequency spectra, now out in a @genetics-gsa.bsky.social special issue: doi.org/10.1093/genetics/iyae210
Characterizing selection on complex traits through conditional frequency spectra
Abstract. Natural selection on complex traits is difficult to study in part due to the ascertainment inherent to genome-wide association studies (GWAS). Th
doi.org
April 18, 2025 at 7:49 PM
a quick note on my paper with @jeffspence.bsky.social and @jkpritch.bsky.social on conditional frequency spectra, now out in a @genetics-gsa.bsky.social special issue: doi.org/10.1093/genetics/iyae210
Reposted by Dandan Peng
Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]
A Litmus Test for Confounding in Polygenic Scores
Polygenic scores (PGSs) are being rapidly adopted for trait prediction in the clinic and beyond. PGSs are often thought of as capturing the direct genetic effect of one's genotype on their phenotype. ...
www.biorxiv.org
February 4, 2025 at 6:04 PM
Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]