John Rittenhouse
LightNews LightNews
John Rittenhouse
@cryect.bsky.social
460 followers 490 following 500 posts
VR Software developer for past ten years currently working at OssoVR on surgical training
Posts Replies Media Videos
Had to go check my first 10 on Steam as well and seems the really old purchases are actually in license activations.
August 15, 2025 at 11:21 PM
I ain't reading all that I'm happy for u tho Or sorry that happened
April 26, 2025 at 4:03 PM
Two planes ere heading to Honduras with none of them having landed yet. In fact, a third plane actually took off after the order was even in the docket.

www.washingtonpost.com/immigration/...
March 18, 2025 at 5:06 PM
March 12, 2025 at 1:07 AM
Well good summary of this is extremely wasteful of taxpayer's dollars.
February 10, 2025 at 9:19 PM
Yes, the planet got destroyed. But for a brief moment we had our norms.
January 17, 2025 at 1:47 AM
Used the 1.28" round touch LCD one for this project.
Project with five rotary dials and a round touch LCD screen in the middle.
December 20, 2024 at 4:48 AM
Didn't realize Pacific Drive was at top of my time played for the year. Against the Storm and Enshrouded don't surprise me though.
Steam Replay 2024 for Cryect. 45 games played, 415 achievements, 86% Keyboard and mouse, 9% time on Pacific Drive, 7% Against the Storm, and 7% Enshrouded
December 18, 2024 at 9:36 PM
@hankgreen.bsky.social I got curious on the cervical cancer video and how Claude approached being asked about why stage 0 cervical cancer were exposed it and it seemed to do a pretty good job.
Claude chat John Why when studying the effectiveness of HPV vaccines do they only look at invasive cervical cancer and exclude stage 0 cervical cancer? The focus on invasive cervical cancer (stages I-IV) rather than stage 0 (carcinoma in situ/CIN3) in HPV vaccine studies stems from several important methodological and clinical considerations: 1. Natural History: Many stage 0 lesions regress spontaneously without treatment, especially in younger women. Including these cases could make it harder to determine the true protective effect of the vaccine since some improvements might happen naturally. 2. Clinical Significance: Invasive cervical cancer represents the most important health outcome, as it has the greatest impact on mortality and morbidity. Stage 0 is considered pre-cancer and is highly treatable with nearly 100% survival rates. 3. Time to Outcome: Stage 0 occurs relatively quickly after HPV infection, while invasive cancer typically takes 10-20 years to develop. Looking at invasive cancer provides better evidence of long-term vaccine protection. 4. Statistical Power: Including stage 0 cases could potentially dilute the statistical power to detect the vaccine's effect on preventing the more serious invasive cancers. However, many studies do look at CIN2+ and CIN3+ as secondary endpoints since these are important precursor lesions. Would you like me to explain more about how these different endpoints are used in vaccine research? Claude chat John Why when studying the effectiveness of HPV vaccines do they only look at invasive cervical cancer and exclude stage 0 cervical cancer? The focus on invasive cervical cancer (stages I-IV) rather than stage 0 (carcinoma in situ/CIN3) in HPV vaccine studies stems from several important methodological and clinical considerations: 1. Natural History: Many stage 0 lesions regress spontaneously without treatment, especially in younger women. Including these cases could make it harder to determine the true protective effect of the vaccine since some improvements might happen naturally. 2. Clinical Significance: Invasive cervical cancer represents the most important health outcome, as it has the greatest impact on mortality and morbidity. Stage 0 is considered pre-cancer and is highly treatable with nearly 100% survival rates. 3. Time to Outcome: Stage 0 occurs relatively quickly after HPV infection, while invasive cancer typically takes 10-20 years to develop. Looking at invasive cancer provides better evidence of long-term vaccine protection. 4. Statistical Power: Including stage 0 cases could potentially dilute the statistical power to detect the vaccine's effect on preventing the more serious invasive cancers. However, many studies do look at CIN2+ and CIN3+ as secondary endpoints since these are important precursor lesions. Would you like me to explain more about how these different endpoints are used in vaccine research? Claude chat John Why when studying the effectiveness of HPV vaccines do they only look at invasive cervical cancer and exclude stage 0 cervical cancer? The focus on invasive cervical cancer (stages I-IV) rather than stage 0 (carcinoma in situ/CIN3) in HPV vaccine studies stems from several important methodological and clinical considerations: 1. Natural History: Many stage 0 lesions regress spontaneously without treatment, especially in younger women. Including these cases could make it harder to determine the true protective effect of the vaccine since some improvements might happen naturally. 2. Clinical Significance: Invasive cervical cancer represents the most important health outcome, as it has the greatest impact on mortality and morbidity. Stage 0 is considered pre-cancer and is highly treatable with nearly 100% survival rates. 3. Time to Outcome: Stage 0 occurs relatively quickly after HPV infection, while invasive cancer typically takes 10-20 years to develop. Looking at invasive cancer provides better evidence of long-term vaccine protection. 4. Statistical Power: Including stage 0 cases could potentially dilute the statistical power to detect the vaccine's effect on preventing the more serious invasive cancers. However, many studies do look at CIN2+ and CIN3+ as secondary endpoints since these are important precursor lesions. Would you like me to explain more about how these different endpoints are used in vaccine research?
December 7, 2024 at 5:44 AM
Yep, and rails give you a nice path to follow before you blanket/place power lines everywhere. Only used drones really for the final tier. Son also loves jumping in a train and driving it around.
Looking over a Satisfactory city of skyscraper factories with a rail station and railways going elsewhere.
November 19, 2024 at 8:58 PM
Supposedly has confirmed he does know after doubling down once.
November 4, 2024 at 9:10 PM
If it works for The Emperor it works for him.
November 4, 2024 at 1:41 AM
Poltergust G-00 turned out well for the son!
November 1, 2024 at 7:35 PM
Definition of woke has gotten much broader than I realized.
October 3, 2024 at 12:10 PM
Don't compare a real rate (real wage is inflation adjusted) to a nominal item (in this the CPI of rent). Here's the correct comparison.
fred.stlouisfed.org/graph/?g=1nOJo
May 9, 2024 at 3:46 PM