Aaron Johnson
@chromatownie.bsky.social
Reposted by Aaron Johnson
How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Molecular determinants underlying functional divergence of TBP homologs
The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...
www.biorxiv.org
October 7, 2025 at 7:43 PM
How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Reposted by Aaron Johnson
Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers
DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...
www.biorxiv.org
September 20, 2025 at 4:10 PM
Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
Reposted by Aaron Johnson
Our paper is out in its final form! Back in April 2023, my coauthor Aleks Radakovic, then a PhD student, approached me after a talk in Chicago to ask what I thought an aminoacylated tRNA would look like if we pulled it through a @nanopore.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Nanopore sequencing of intact aminoacylated tRNAs - Nature Communications
Accurate protein synthesis depends on aminoacylated tRNAs, but their identities have been hard to measure. Here, authors present aa-tRNA-seq, a nanopore-based method that reveals the amino acid, seque...
doi.org
August 22, 2025 at 9:08 PM
Our paper is out in its final form! Back in April 2023, my coauthor Aleks Radakovic, then a PhD student, approached me after a talk in Chicago to ask what I thought an aminoacylated tRNA would look like if we pulled it through a @nanopore.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Aaron Johnson
if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial.
rdcu.be/exXBX
rdcu.be/exXBX
July 26, 2025 at 7:09 PM
if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial.
rdcu.be/exXBX
rdcu.be/exXBX
Reposted by Aaron Johnson
Today is a devastating reminder that infectious diseases don’t care what your ‘beliefs’ are. Everyone is likely to be affected directly or indirectly. Serious challenges require serious people at the helm. Protect your loved ones. Educate. Advocate. The cost of not doing so will be too much to bear.
February 26, 2025 at 11:26 PM
Today is a devastating reminder that infectious diseases don’t care what your ‘beliefs’ are. Everyone is likely to be affected directly or indirectly. Serious challenges require serious people at the helm. Protect your loved ones. Educate. Advocate. The cost of not doing so will be too much to bear.
Reposted by Aaron Johnson
ATTENTION (PLEASE SHARE)
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
a poster that says if life gives you lemon make lemonade on it
ALT: a poster that says if life gives you lemon make lemonade on it
media.tenor.com
February 15, 2025 at 3:37 PM
ATTENTION (PLEASE SHARE)
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.