Charlotte Crowe
@charlcrowe.bsky.social
Postdoc @UoD @CeTPD with Alessio Ciulli
Structural & chemical biology in Targeted Protein Degradation
Structural & chemical biology in Targeted Protein Degradation
Reposted by Charlotte Crowe
Exciting @biorxivpreprint.bsky.social by the groups of @pjcossar.bsky.social and @alessiociulli.bsky.social. They use a molecular glue between 14-3-3 and an intrinsically disordered domain of ERα to develop a molecular glue-based PROTAC recruiting VHL. doi.org/10.1101/2025...
#TPD #ChemSky #ChemBio
#TPD #ChemSky #ChemBio
Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design
Proteins lacking defined ligandable pockets remain challenging drug targets. Here, we develop a molecular glue-based PROTAC (MGPROTACs) approach that chemically conjugates a molecular glue stabilizer ...
doi.org
November 19, 2025 at 9:04 AM
Exciting @biorxivpreprint.bsky.social by the groups of @pjcossar.bsky.social and @alessiociulli.bsky.social. They use a molecular glue between 14-3-3 and an intrinsically disordered domain of ERα to develop a molecular glue-based PROTAC recruiting VHL. doi.org/10.1101/2025...
#TPD #ChemSky #ChemBio
#TPD #ChemSky #ChemBio
Reposted by Charlotte Crowe
Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design www.biorxiv.org/content/10.1101/2025.11.17.688825v1 #cryoem
November 18, 2025 at 8:10 AM
Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design www.biorxiv.org/content/10.1101/2025.11.17.688825v1 #cryoem
From degradation to stabilisation!
Reprogramming the VHL-degrader CM11 into VHL-stabilisers through linker design, locking a non-ubiquitinable ternary complex.
🔗https://www.biorxiv.org/content/10.1101/2025.11.18.689129v1.full.pdf
Reprogramming the VHL-degrader CM11 into VHL-stabilisers through linker design, locking a non-ubiquitinable ternary complex.
🔗https://www.biorxiv.org/content/10.1101/2025.11.18.689129v1.full.pdf
November 19, 2025 at 5:02 PM
From degradation to stabilisation!
Reprogramming the VHL-degrader CM11 into VHL-stabilisers through linker design, locking a non-ubiquitinable ternary complex.
🔗https://www.biorxiv.org/content/10.1101/2025.11.18.689129v1.full.pdf
Reprogramming the VHL-degrader CM11 into VHL-stabilisers through linker design, locking a non-ubiquitinable ternary complex.
🔗https://www.biorxiv.org/content/10.1101/2025.11.18.689129v1.full.pdf
House of VHL meets house of 14-3-3 🤝
Presenting our study “Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design”
🔗https://www.biorxiv.org/content/10.1101/2025.11.17.688825v1
Presenting our study “Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design”
🔗https://www.biorxiv.org/content/10.1101/2025.11.17.688825v1
November 19, 2025 at 1:47 AM
House of VHL meets house of 14-3-3 🤝
Presenting our study “Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design”
🔗https://www.biorxiv.org/content/10.1101/2025.11.17.688825v1
Presenting our study “Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design”
🔗https://www.biorxiv.org/content/10.1101/2025.11.17.688825v1
After the Krios I's 10-year birthday earlier this year (full story can be found here: lnkd.in/eCKF3vBF), it was awesome to visit the eBIC facilities at @diamondlightsource.bsky.social and see that the epic party hat still lives on 🥳
October 15, 2025 at 7:43 PM
After the Krios I's 10-year birthday earlier this year (full story can be found here: lnkd.in/eCKF3vBF), it was awesome to visit the eBIC facilities at @diamondlightsource.bsky.social and see that the epic party hat still lives on 🥳
My first 🦋 post! Awesome view over the haar (fog) over the river Tay yesterday afternoon, on the train heading down to
@diamondlightsource.bsky.social for the CCP-EM Icknield workshop - looking forward to a great week of cryo-EM data processing and model building 🔬
@diamondlightsource.bsky.social for the CCP-EM Icknield workshop - looking forward to a great week of cryo-EM data processing and model building 🔬
October 13, 2025 at 8:22 PM
My first 🦋 post! Awesome view over the haar (fog) over the river Tay yesterday afternoon, on the train heading down to
@diamondlightsource.bsky.social for the CCP-EM Icknield workshop - looking forward to a great week of cryo-EM data processing and model building 🔬
@diamondlightsource.bsky.social for the CCP-EM Icknield workshop - looking forward to a great week of cryo-EM data processing and model building 🔬