Carter Lab
@carter-lab.bsky.social
A lab at the MRC LMB, Cambridge. Interested in dynein, microtubules, cytoskeleton, electron microscopy and much more.
Reposted by Carter Lab
Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...
Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization https://www.biorxiv.org/content/10.1101/2025.08.02.668268v1
August 5, 2025 at 8:13 AM
Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 5, 2025 at 10:43 AM
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Check out this exciting new study from the @rgassmann.bsky.social lab that we are thrilled to be part of — revealing that CDR2 is a dynein adaptor that regulates ER sheet organization!!
Teixeira et al. @i3suporto.bsky.social identify the onconeural antigen CDR2 as an ER-localized adaptor for the microtubule-based motor cytoplasmic dynein-1 & show that CDR2 contributes to ER organization thru. its interaction w/ the integral ER membrane protein kinectin. rupress.org/jcb/article/...
July 11, 2025 at 3:28 PM
Check out this exciting new study from the @rgassmann.bsky.social lab that we are thrilled to be part of — revealing that CDR2 is a dynein adaptor that regulates ER sheet organization!!
In Today's #journalclub, we had a look at how TinA can make the kinesin-14 KlpA to switch to minus-end processivity on microtubules in vitro:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
TinA enables kinesin-14/KlpA to exhibit processive minus-end-directed motility
Kinesin-14 motors contribute to spindle assembly by localizing to spindle poles and anchoring the minus ends of spindle microtubules. Unlike other kinesin-14 motors, KlpA uniquely exhibits plus-end-di...
www.biorxiv.org
February 28, 2025 at 1:31 PM
In Today's #journalclub, we had a look at how TinA can make the kinesin-14 KlpA to switch to minus-end processivity on microtubules in vitro:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 21, 2025 at 12:56 PM
Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new study reveals how alternative splicing fine-tunes dynein cargo specificity! ZYG-12/Hook uses different isoforms to recruit dynein to either early endosomes or the nuclear envelope, showcasing a clever mechanism for organelle-specific transport. #journalclub
www.molbiolcell.org/doi/abs/10.1...
www.molbiolcell.org/doi/abs/10.1...
Molecular Biology of the Cell (MBoC)
www.molbiolcell.org
February 7, 2025 at 11:53 AM
A new study reveals how alternative splicing fine-tunes dynein cargo specificity! ZYG-12/Hook uses different isoforms to recruit dynein to either early endosomes or the nuclear envelope, showcasing a clever mechanism for organelle-specific transport. #journalclub
www.molbiolcell.org/doi/abs/10.1...
www.molbiolcell.org/doi/abs/10.1...
Today in #journalclub, we looked at the new study from Nguyen et al. showing how Cryo-EM captures early steps in dynein activation by LIS1. They identified a novel ‘Pre-Chi’ intermediate, shedding light on how LIS1 relieves dynein autoinhibition!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Cryo-EM captures early intermediate steps in dynein activation by LIS1
Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited “Phi” state and requires conformational changes to assemble with its cofa...
www.biorxiv.org
February 7, 2025 at 11:48 AM
Today in #journalclub, we looked at the new study from Nguyen et al. showing how Cryo-EM captures early steps in dynein activation by LIS1. They identified a novel ‘Pre-Chi’ intermediate, shedding light on how LIS1 relieves dynein autoinhibition!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Carter Lab
First #JournalClub on the blue side: an exciting story about dynein at the kinetochore and its role in biorientation!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore - Nature Communications
Mitotic chromosomes recruit multiple microtubule-directed activities to ensure their faithful segregation. Using an approach where only one major activity is present, the authors reveal sufficiency of...
www.nature.com
November 15, 2024 at 11:30 AM
First #JournalClub on the blue side: an exciting story about dynein at the kinetochore and its role in biorientation!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
As my lab's first post on Bluesky. If you are a UK Structural Biologist please come to our one day meeting on Friday 6th December
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ
November 14, 2024 at 10:52 AM
As my lab's first post on Bluesky. If you are a UK Structural Biologist please come to our one day meeting on Friday 6th December
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ
Reposted by Carter Lab
❗️Exciting science alert!! Come join us at the BCA Winter Meeting at the MRC Laboratory of Molecular Biology, Cambridge, 6th December. Short talks available - a great opportunity for early career researchers to present.. bit.ly/4fDEqfZ
November 6, 2024 at 8:52 PM
❗️Exciting science alert!! Come join us at the BCA Winter Meeting at the MRC Laboratory of Molecular Biology, Cambridge, 6th December. Short talks available - a great opportunity for early career researchers to present.. bit.ly/4fDEqfZ
Reposted by Carter Lab
Our new preprint from Briggs lab is out! We solved the in-virus #cryoEM structure of the HIV matrix protein by SPA. The structure led us to a discovery resolving a long mystery in HIV biology – a peptide SP2 triggers the maturation of the HIV matrix domain. A 🧵 1/x
Paper: tinyurl.com/c7szhtfa
Paper: tinyurl.com/c7szhtfa
November 12, 2024 at 9:04 PM
Our new preprint from Briggs lab is out! We solved the in-virus #cryoEM structure of the HIV matrix protein by SPA. The structure led us to a discovery resolving a long mystery in HIV biology – a peptide SP2 triggers the maturation of the HIV matrix domain. A 🧵 1/x
Paper: tinyurl.com/c7szhtfa
Paper: tinyurl.com/c7szhtfa
Reposted by Carter Lab
Nice to see @pilhoferlab.bsky.social here !!
November 13, 2024 at 5:24 PM
Nice to see @pilhoferlab.bsky.social here !!