Yves Brun lab
@brunlabcaulo.bsky.social
We like to look at bacteria do the things they do. Université de Montréal.
Pinned
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
Wow, really cool work! Congratulations!
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 11:57 PM
Wow, really cool work! Congratulations!
As mentioned, here is the preprint by Jensen and @viollierpat.bsky.social on the in situ structure of the Tad pilus. www.biorxiv.org/content/10.1.... Nice work and great to see that we are seeing the same thing! Our preprint: www.biorxiv.org/content/10.1... #microsky
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
November 8, 2025 at 7:35 PM
As mentioned, here is the preprint by Jensen and @viollierpat.bsky.social on the in situ structure of the Tad pilus. www.biorxiv.org/content/10.1.... Nice work and great to see that we are seeing the same thing! Our preprint: www.biorxiv.org/content/10.1... #microsky
Reposted by Yves Brun lab
Great collaboration with @brunlabcaulo.bsky.social for resolving the Tad pilus machine structure by cryo-ET. Beautiful work by graduate students James Iarocci and Ryu Williston in our lab.
Preprint:https://www.biorxiv.org/content/10.1101/2025.11.05.686773v1
Preprint:https://www.biorxiv.org/content/10.1101/2025.11.05.686773v1
November 6, 2025 at 3:58 PM
Great collaboration with @brunlabcaulo.bsky.social for resolving the Tad pilus machine structure by cryo-ET. Beautiful work by graduate students James Iarocci and Ryu Williston in our lab.
Preprint:https://www.biorxiv.org/content/10.1101/2025.11.05.686773v1
Preprint:https://www.biorxiv.org/content/10.1101/2025.11.05.686773v1
More useful with the link #microsky www.biorxiv.org/content/10.1...
November 6, 2025 at 3:57 PM
More useful with the link #microsky www.biorxiv.org/content/10.1...
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
November 6, 2025 at 3:51 PM
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
Forgot to post the recently published version of this paper on the role of a minor pilin-like protein in surface sensing journals.asm.org/doi/10.1128/...
October 31, 2025 at 6:54 PM
Forgot to post the recently published version of this paper on the role of a minor pilin-like protein in surface sensing journals.asm.org/doi/10.1128/...
Light reading to distract me from the news. Yet it is strangely familiar.
September 19, 2025 at 1:38 AM
Light reading to distract me from the news. Yet it is strangely familiar.
Why do we always submit grant proposals at the last minute? This never ceases to amaze me.
July 15, 2025 at 2:00 AM
Why do we always submit grant proposals at the last minute? This never ceases to amaze me.
Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4...
July 9, 2025 at 5:56 PM
Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4...
As I was saying, happy to be back home! Cheers!
July 5, 2025 at 12:34 AM
As I was saying, happy to be back home! Cheers!
Congratulations Marie! Immensely proud! Looking forward to seeing where you take your project on evolution of bacterial elongation.
Excited to share that I have been appointed F.R.S.-FNRS Research Associate to launch my independent research group at the University of Namur!
We will study the diversity, regulation & environmental control of bacterial cell elongation.
More soon- new projects, collaborations & opportunities ahead!
We will study the diversity, regulation & environmental control of bacterial cell elongation.
More soon- new projects, collaborations & opportunities ahead!
July 4, 2025 at 9:01 PM
Congratulations Marie! Immensely proud! Looking forward to seeing where you take your project on evolution of bacterial elongation.
Sabbatical is over! I really enjoyed my time in Marseille for 10 months @lcbofficiel.bsky.social but very happy to be back in Montreal and with my lab. Also, the view from my office 😀
July 4, 2025 at 5:39 PM
Sabbatical is over! I really enjoyed my time in Marseille for 10 months @lcbofficiel.bsky.social but very happy to be back in Montreal and with my lab. Also, the view from my office 😀
Excited to see our automated HT growth/microscopy screening platform coming together. Pictured: the intermediate version to screen 5-10,000/day unattended. Diagrammed is the full platform due next summer after renovations @ 20,000/day and integrated with our colony picker.
July 4, 2025 at 5:22 PM
Excited to see our automated HT growth/microscopy screening platform coming together. Pictured: the intermediate version to screen 5-10,000/day unattended. Diagrammed is the full platform due next summer after renovations @ 20,000/day and integrated with our colony picker.
Reposted by Yves Brun lab
Exciting news!
My work with Liu Yang in the @brunlabcaulo.bsky.social, “Phenotypic plasticity in cell elongation among closely related bacterial species”, has been selected as an Editors’ Highlight in @natcomms.nature.com under Microbiology and infectious diseases!
Check it out here:
My work with Liu Yang in the @brunlabcaulo.bsky.social, “Phenotypic plasticity in cell elongation among closely related bacterial species”, has been selected as an Editors’ Highlight in @natcomms.nature.com under Microbiology and infectious diseases!
Check it out here:
Editors' Highlights | Nature Communications
Editors' Highlights
www.nature.com
June 18, 2025 at 2:04 AM
Exciting news!
My work with Liu Yang in the @brunlabcaulo.bsky.social, “Phenotypic plasticity in cell elongation among closely related bacterial species”, has been selected as an Editors’ Highlight in @natcomms.nature.com under Microbiology and infectious diseases!
Check it out here:
My work with Liu Yang in the @brunlabcaulo.bsky.social, “Phenotypic plasticity in cell elongation among closely related bacterial species”, has been selected as an Editors’ Highlight in @natcomms.nature.com under Microbiology and infectious diseases!
Check it out here:
How does your favorite species elongate? 🧵 "Phenotypic plasticity in bacterial elongation among closely related species". Happy to see this paper in print @natcomms.nature.com. Nice work by @mariedelaby.bsky.social, Liu Yang et al. See original 🧵, different colours, same data and conclusions.
June 2, 2025 at 3:54 PM
How does your favorite species elongate? 🧵 "Phenotypic plasticity in bacterial elongation among closely related species". Happy to see this paper in print @natcomms.nature.com. Nice work by @mariedelaby.bsky.social, Liu Yang et al. See original 🧵, different colours, same data and conclusions.
Excited to be in Grenoble surrounded by mountains to give a seminar today at the IBS where I was on sabbatical 10 years ago.
May 16, 2025 at 5:38 AM
Excited to be in Grenoble surrounded by mountains to give a seminar today at the IBS where I was on sabbatical 10 years ago.
Reposted by Yves Brun lab
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
May 2, 2025 at 2:39 PM
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Indeed, please also check the paper on the same topic by
@lowlab.bsky.social published a few months ago in the same journal.
@lowlab.bsky.social published a few months ago in the same journal.
We encourage you to also check out an alternative model of how CpaF assembles the Tad pilus proposed by @lowlab.bsky.social published a few months ago in the same journal.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bidirectional pilus processing in the Tad pilus system motor CpaF - Nature Communications
The ATPase CpaF from C. crescentus powers pilus dynamics in the bacterial Tad pilus system. Cryo-EM and light microscopy characterisation of CpaF uncovers a mechanism for how CpaF may drive both pilus...
www.nature.com
April 24, 2025 at 7:23 AM
Indeed, please also check the paper on the same topic by
@lowlab.bsky.social published a few months ago in the same journal.
@lowlab.bsky.social published a few months ago in the same journal.
Great to see @ianyyen.bsky.social's first paper in print! He deserves major congratulations for driving a stimulating collaboration: he determined structures of the Tad pilus ATPase CpaF from Caulobacter and proposes how CpaF employs a rotary mechanism of catalysis to drive pilus assembly #microsky
April 24, 2025 at 7:21 AM
Great to see @ianyyen.bsky.social's first paper in print! He deserves major congratulations for driving a stimulating collaboration: he determined structures of the Tad pilus ATPase CpaF from Caulobacter and proposes how CpaF employs a rotary mechanism of catalysis to drive pilus assembly #microsky
Reposted by Yves Brun lab
This is why the new threat against university funding in Canada is concerning, clearly a fraction of the population here do not understand either how things work and universities contribute.
👇🎯💯
All of it, but especially this:
All of it, but especially this:
April 23, 2025 at 5:40 PM
This is why the new threat against university funding in Canada is concerning, clearly a fraction of the population here do not understand either how things work and universities contribute.
Reposted by Yves Brun lab
New paper from the Vecchiarelli Lab! 🧵
pubs.acs.org/doi/10.1021/...
In collaboration with Lu-Ning Liu lab.
Congratulations to first author Claudia Mak!
@claudiamak.bsky.social
P.S. Claudia is looking for postdocs in protein biochemistry!
Pls ReSkeet
pubs.acs.org/doi/10.1021/...
In collaboration with Lu-Ning Liu lab.
Congratulations to first author Claudia Mak!
@claudiamak.bsky.social
P.S. Claudia is looking for postdocs in protein biochemistry!
Pls ReSkeet
Carboxysome Shell Protein CcmK2 Assembles into Monodisperse and pH-Reversible Microparticles
Synthetic nano- and microparticles have become essential tools in biotechnology. Protein-based compartments offer distinct advantages over synthetic particles, such as biodegradability and biocompatib...
pubs.acs.org
March 31, 2025 at 4:42 PM
New paper from the Vecchiarelli Lab! 🧵
pubs.acs.org/doi/10.1021/...
In collaboration with Lu-Ning Liu lab.
Congratulations to first author Claudia Mak!
@claudiamak.bsky.social
P.S. Claudia is looking for postdocs in protein biochemistry!
Pls ReSkeet
pubs.acs.org/doi/10.1021/...
In collaboration with Lu-Ning Liu lab.
Congratulations to first author Claudia Mak!
@claudiamak.bsky.social
P.S. Claudia is looking for postdocs in protein biochemistry!
Pls ReSkeet
Reposted by Yves Brun lab
>1900 members of the National Academies of Science, Engineering & Medicine issued a statement supporting science for the benefit of all citizens, and ... 1/2
docs.google.com/document/d/1...
docs.google.com/document/d/1...
Public Statement on Supporting Science for the Benefit of All Citizens
TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...
docs.google.com
March 31, 2025 at 4:28 PM
>1900 members of the National Academies of Science, Engineering & Medicine issued a statement supporting science for the benefit of all citizens, and ... 1/2
docs.google.com/document/d/1...
docs.google.com/document/d/1...