Boël Lab
@boellab.bsky.social
We are a research lab located in Paris, France.
We work on the fundamental aspect of protein synthesis mechanisms and regulations.
We work on the fundamental aspect of protein synthesis mechanisms and regulations.
Pinned
Boël Lab
@boellab.bsky.social
· Dec 23
Base composition at the start of the coding sequence controls the balance between translation initiation and mRNA degradation in E. coli
Abstract. Protein synthesis efficiency is highly dependent on the messenger RNA (mRNA) coding sequence. Furthermore, there is extensive evidence of a corre
academic.oup.com
Our latest paper on protein expression and mRNA stability is out!
academic.oup.com/nar/article/...
Check out how to increase your protein output with a simple trick.
Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group.
#RNAsky #ribosome #EGM
academic.oup.com/nar/article/...
Check out how to increase your protein output with a simple trick.
Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group.
#RNAsky #ribosome #EGM
Reposted by Boël Lab
Just in time for 2026! 🎆 Presenting a nascent-centric view on the shape of the ribosomal exit tunnel topology, based on MD-derived occupancy maps for 55 distinct ribosomes. 🧶🧬🖥️
📄 Read the preprint: biorxiv.org/content/10.6...
#StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics
📄 Read the preprint: biorxiv.org/content/10.6...
#StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics
Evolution of the ribosomal exit tunnel through the eyes of the nascent chain
The ribosomal exit tunnel is a universally conserved feature of the large subunit that directs the nascent polypeptide chain into the cellular environment and is involved in co-translational folding, ...
biorxiv.org
December 30, 2025 at 10:30 PM
Just in time for 2026! 🎆 Presenting a nascent-centric view on the shape of the ribosomal exit tunnel topology, based on MD-derived occupancy maps for 55 distinct ribosomes. 🧶🧬🖥️
📄 Read the preprint: biorxiv.org/content/10.6...
#StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics
📄 Read the preprint: biorxiv.org/content/10.6...
#StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics
Reposted by Boël Lab
This work was also our first time doing membrane localization (way to go Cassidy)! And so proud of Bella’s gorgeous Paenibacillus tree showing the distribution of the transmembrane containing Spo0B! Also it’s the lab’s first paper without ribosomes 🫨, but don’t worry - the ribosomes made the Spo0B!
December 30, 2025 at 2:01 PM
This work was also our first time doing membrane localization (way to go Cassidy)! And so proud of Bella’s gorgeous Paenibacillus tree showing the distribution of the transmembrane containing Spo0B! Also it’s the lab’s first paper without ribosomes 🫨, but don’t worry - the ribosomes made the Spo0B!
This sequence optimization technique is also included in the overall sequence optimization tool available on our server: opt.williams.edu
(See our publication: www.sciencedirect.com/science/arti...)
(See our publication: www.sciencedirect.com/science/arti...)
December 23, 2025 at 10:32 AM
This sequence optimization technique is also included in the overall sequence optimization tool available on our server: opt.williams.edu
(See our publication: www.sciencedirect.com/science/arti...)
(See our publication: www.sciencedirect.com/science/arti...)
In this study, we highlight the importance of the base composition of the first codons for protein expression. An increased abundance of adenine (A) and a decrease in guanine (G) enhance expression and improve mRNA stability. The mediator of this effect is the ribosome.
Our latest paper on protein expression and mRNA stability is out!
academic.oup.com/nar/article/...
Check out how to increase your protein output with a simple trick.
Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group.
#RNAsky #ribosome #EGM
academic.oup.com/nar/article/...
Check out how to increase your protein output with a simple trick.
Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group.
#RNAsky #ribosome #EGM
Base composition at the start of the coding sequence controls the balance between translation initiation and mRNA degradation in E. coli
Abstract. Protein synthesis efficiency is highly dependent on the messenger RNA (mRNA) coding sequence. Furthermore, there is extensive evidence of a corre
academic.oup.com
December 23, 2025 at 10:31 AM
In this study, we highlight the importance of the base composition of the first codons for protein expression. An increased abundance of adenine (A) and a decrease in guanine (G) enhance expression and improve mRNA stability. The mediator of this effect is the ribosome.
Our latest paper on protein expression and mRNA stability is out!
academic.oup.com/nar/article/...
Check out how to increase your protein output with a simple trick.
Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group.
#RNAsky #ribosome #EGM
academic.oup.com/nar/article/...
Check out how to increase your protein output with a simple trick.
Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group.
#RNAsky #ribosome #EGM
Base composition at the start of the coding sequence controls the balance between translation initiation and mRNA degradation in E. coli
Abstract. Protein synthesis efficiency is highly dependent on the messenger RNA (mRNA) coding sequence. Furthermore, there is extensive evidence of a corre
academic.oup.com
December 23, 2025 at 10:29 AM
Our latest paper on protein expression and mRNA stability is out!
academic.oup.com/nar/article/...
Check out how to increase your protein output with a simple trick.
Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group.
#RNAsky #ribosome #EGM
academic.oup.com/nar/article/...
Check out how to increase your protein output with a simple trick.
Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group.
#RNAsky #ribosome #EGM
Reposted by Boël Lab
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
www.science.org
September 6, 2025 at 9:35 AM
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
A useful toolkit 🧰⚙️
Happy to share our genetic toolkit designed to make your gene editing (life) easier, faster and very efficient!
Also suitable to build saturated chromosomal variant libraries using oligo-recombineering with extra short homology arms!
www.biorxiv.org/content/10.1...
Also suitable to build saturated chromosomal variant libraries using oligo-recombineering with extra short homology arms!
www.biorxiv.org/content/10.1...
March 24, 2025 at 5:25 PM
A useful toolkit 🧰⚙️
Thanks for the great meeting.
It was so nice to see everyone and enjoy great science. 🔤❤️
It was so nice to see everyone and enjoy great science. 🔤❤️
We had an amazing time with the ABC family and already miss you all! Can’t wait to hear your exciting talks, have great discussions, and hit the slopes of the Alps again. #ABC2025
See you next time!🗻⛷️🚠🧬🧫🧪💙
See you next time!🗻⛷️🚠🧬🧫🧪💙
March 7, 2025 at 9:23 AM
Thanks for the great meeting.
It was so nice to see everyone and enjoy great science. 🔤❤️
It was so nice to see everyone and enjoy great science. 🔤❤️
Reposted by Boël Lab
In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 1, 2025 at 1:40 PM
In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I am very happy to present our new manuscript in collaboration with the Aalbet and Hunt Labs on DNA sequence optimization for high expression in Escherichia coli as well as in in vitro translation assays (doi.org/10.1016/j.jm...)
Redirecting
doi.org
March 3, 2025 at 11:40 AM
I am very happy to present our new manuscript in collaboration with the Aalbet and Hunt Labs on DNA sequence optimization for high expression in Escherichia coli as well as in in vitro translation assays (doi.org/10.1016/j.jm...)
Super happy to be with the ABC family
It's ABC protein, NOT transporter! We are an inclusive bunch! ❤️
Gregory Boel introducing the morning speakers! #ABC2025
Gregory Boel introducing the morning speakers! #ABC2025
March 1, 2025 at 8:23 PM
Super happy to be with the ABC family
Reposted by Boël Lab
Direct RNA sequencing coupled with adaptive sampling enriches RNAs of interest in the transcriptome www.nature.com/articles/s41... #jcampubs
Direct RNA sequencing coupled with adaptive sampling enriches RNAs of interest in the transcriptome ...
It can be difficult to find rare transcripts when sequencing a transcriptome. Here the authors show adaptive sampling on direct RNA runs to increase the likelihood of finding less frequent ones while ...
www.nature.com
January 12, 2024 at 2:29 PM
Direct RNA sequencing coupled with adaptive sampling enriches RNAs of interest in the transcriptome www.nature.com/articles/s41... #jcampubs
Reposted by Boël Lab
check it out!
RiboGraph: An interactive visualization system for ribosome profiling data at read length resolution
🔎 microprotein
🧬 + 🖥️
www.biorxiv.org/content/10.1...
RiboGraph: An interactive visualization system for ribosome profiling data at read length resolution
🔎 microprotein
🧬 + 🖥️
www.biorxiv.org/content/10.1...
RiboGraph: An interactive visualization system for ribosome profiling data at read length resolution
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
January 13, 2024 at 2:31 AM
check it out!
RiboGraph: An interactive visualization system for ribosome profiling data at read length resolution
🔎 microprotein
🧬 + 🖥️
www.biorxiv.org/content/10.1...
RiboGraph: An interactive visualization system for ribosome profiling data at read length resolution
🔎 microprotein
🧬 + 🖥️
www.biorxiv.org/content/10.1...
Reposted by Boël Lab
www.biorxiv.org/content/10.1...
Time resolution in cryo-EM using a novel PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling.
Just accepted by CELL as a resource article.
Time resolution in cryo-EM using a novel PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling.
Just accepted by CELL as a resource article.
November 25, 2023 at 8:58 PM
www.biorxiv.org/content/10.1...
Time resolution in cryo-EM using a novel PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling.
Just accepted by CELL as a resource article.
Time resolution in cryo-EM using a novel PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling.
Just accepted by CELL as a resource article.
Hi everyone,
We are new on Bluesky 😀. We are a group of microbiologists 🧫🔬 interested in mRNA translation mechanisms and regulation.
We wish you a wonderful year in 2024 🥳🍾 and will be back soon with more news.
We are new on Bluesky 😀. We are a group of microbiologists 🧫🔬 interested in mRNA translation mechanisms and regulation.
We wish you a wonderful year in 2024 🥳🍾 and will be back soon with more news.
January 3, 2024 at 12:30 PM
Hi everyone,
We are new on Bluesky 😀. We are a group of microbiologists 🧫🔬 interested in mRNA translation mechanisms and regulation.
We wish you a wonderful year in 2024 🥳🍾 and will be back soon with more news.
We are new on Bluesky 😀. We are a group of microbiologists 🧫🔬 interested in mRNA translation mechanisms and regulation.
We wish you a wonderful year in 2024 🥳🍾 and will be back soon with more news.
Reposted by Boël Lab
Global regulation via modulation of ribosome pausing by EttA https://www.biorxiv.org/content/10.1101/2023.10.17.562674v1
Global regulation via modulation of ribosome pausing by EttA https://www.biorxiv.org/content/10.1101/2023.10.17.562674v1
Having multiple rounds of translation of the same mRNA is a key feature of the Central Dogma that cr
www.biorxiv.org
October 18, 2023 at 3:27 AM
Global regulation via modulation of ribosome pausing by EttA https://www.biorxiv.org/content/10.1101/2023.10.17.562674v1