Blurton-Jones Lab
@blurtonjoneslab.bsky.social
Neuroimmunology lab at UC Irvine studying the role of microglia in Alzheimer’s disease and developing iPSC-microglia based therapeutic approaches.
Reposted by Blurton-Jones Lab
Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases www.sciencedirect.com/science/arti...
March 25, 2025 at 5:40 PM
Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases www.sciencedirect.com/science/arti...
Reposted by Blurton-Jones Lab
Exciting work @blurtonjoneslab.bsky.social: CRISPR-engineered iPSC-microglia use the plaque-responsive CD9 promoter to deliver Aβ-degrading neprilysin across the brain-- reducing plaques, inflammation & synaptic loss. A promising new cell therapy platform for AD www.sciencedirect.com/science/arti...
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…
www.sciencedirect.com
April 25, 2025 at 6:23 PM
Exciting work @blurtonjoneslab.bsky.social: CRISPR-engineered iPSC-microglia use the plaque-responsive CD9 promoter to deliver Aβ-degrading neprilysin across the brain-- reducing plaques, inflammation & synaptic loss. A promising new cell therapy platform for AD www.sciencedirect.com/science/arti...
Reposted by Blurton-Jones Lab
This amazing news made my week! 🎊 I’m beyond blessed to be part of the @brightfocus.bsky.social community while studying the protective microglial responses in the context of Alzheimer’s disease. Super thankful to @blurtonjoneslab.bsky.social and the entire MBJ team for their continuous support!
April 12, 2025 at 12:28 AM
This amazing news made my week! 🎊 I’m beyond blessed to be part of the @brightfocus.bsky.social community while studying the protective microglial responses in the context of Alzheimer’s disease. Super thankful to @blurtonjoneslab.bsky.social and the entire MBJ team for their continuous support!
Reposted by Blurton-Jones Lab
Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…
sciencedirect.com
April 18, 2025 at 3:03 PM
Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
Reposted by Blurton-Jones Lab
Congratulations to
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…
www.sciencedirect.com
April 14, 2025 at 6:54 PM
Congratulations to
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...
Reposted by Blurton-Jones Lab
This message needs to be heard widely.
NIH funding delivers exponential economic returns — Harvard Gazette
Report finds all 50 states reap gains in patient health, job creation, research resources, business development.
news.harvard.edu
March 12, 2025 at 11:51 AM
This message needs to be heard widely.
Reposted by Blurton-Jones Lab
Reposted by Blurton-Jones Lab
At @standupforscience.bsky.social and the signs are statistically significantly excellent
March 7, 2025 at 6:51 PM
At @standupforscience.bsky.social and the signs are statistically significantly excellent
Reposted by Blurton-Jones Lab
@baldwin.senate.gov released a press release calling out the administration for damaging the Alzheimer's Disease Research Center network through it's screwing up NIH processes.
www.baldwin.senate.gov/news/press-r...
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www.baldwin.senate.gov/news/press-r...
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Baldwin Blasts Trump Administration for Stopping $65 Million for Alzheimer’s Disease Research | U.S. Senator Tammy Baldwin of Wisconsin
WASHINGTON, D.C. – Today, U.S. Senator Tammy Baldwin (D-WI), Ranking Member of the Senate...
www.baldwin.senate.gov
March 3, 2025 at 10:01 PM
@baldwin.senate.gov released a press release calling out the administration for damaging the Alzheimer's Disease Research Center network through it's screwing up NIH processes.
www.baldwin.senate.gov/news/press-r...
1/2
www.baldwin.senate.gov/news/press-r...
1/2
Reposted by Blurton-Jones Lab
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
www.nature.com
March 4, 2025 at 1:31 AM
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Reposted by Blurton-Jones Lab
Reposted by Blurton-Jones Lab
Elon Musk and his 19-year-olds have now disrupted the approval of medical devices that save lives.
Every member of Congress bears a responsibility to stop this right now.
Every member of Congress bears a responsibility to stop this right now.
February 25, 2025 at 10:24 PM
Elon Musk and his 19-year-olds have now disrupted the approval of medical devices that save lives.
Every member of Congress bears a responsibility to stop this right now.
Every member of Congress bears a responsibility to stop this right now.
Reposted by Blurton-Jones Lab
Executive wants to frame the NIH indirects cut as $4B in savings.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
www.nih.gov
February 8, 2025 at 3:08 AM
Executive wants to frame the NIH indirects cut as $4B in savings.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
Reposted by Blurton-Jones Lab
This is what amounts to an ILLEGAL & indiscriminate funding cut for research centers everywhere. It will mean shuttering labs across the country, layoffs in red & blue states, and derailing lifesaving research on everything from cancer to opioid addiction.
We all need to speak out to save lives.
We all need to speak out to save lives.
February 8, 2025 at 2:02 AM
This is what amounts to an ILLEGAL & indiscriminate funding cut for research centers everywhere. It will mean shuttering labs across the country, layoffs in red & blue states, and derailing lifesaving research on everything from cancer to opioid addiction.
We all need to speak out to save lives.
We all need to speak out to save lives.
Reposted by Blurton-Jones Lab
The Senate HELP Committee has jurisdiction over NIH.
GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC.
Research universities and hospitals in those states need to be extra loud.
GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC.
Research universities and hospitals in those states need to be extra loud.
February 8, 2025 at 1:24 AM
The Senate HELP Committee has jurisdiction over NIH.
GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC.
Research universities and hospitals in those states need to be extra loud.
GOP members of the committee represent AK, AL, IN, FL, KS, KY, LA, ME, MO, OH, and SC.
Research universities and hospitals in those states need to be extra loud.
Reposted by Blurton-Jones Lab
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
Reposted by Blurton-Jones Lab
This is the end of science as we know it if it stands—15% IDCs for all NIH Grants.
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 7, 2025 at 11:05 PM
This is the end of science as we know it if it stands—15% IDCs for all NIH Grants.
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Reposted by Blurton-Jones Lab
This is a full on assault on education. The US is the world leader in innovation research, technology only because we as a society support it. Without support for world leading research, we will brain drain and the best and brightest will go where research thrives
www.statnews.com/2025/02/07/n...
www.statnews.com/2025/02/07/n...
NIH plans to slash support for indirect research costs, sending shockwaves through science
The NIH said Friday night that it would slash support for indirect costs on all existing and future grants to 15%
www.statnews.com
February 8, 2025 at 1:59 AM
This is a full on assault on education. The US is the world leader in innovation research, technology only because we as a society support it. Without support for world leading research, we will brain drain and the best and brightest will go where research thrives
www.statnews.com/2025/02/07/n...
www.statnews.com/2025/02/07/n...
Reposted by Blurton-Jones Lab
Un-fucking-believable.
I have... no words.
This is how you destroy science and also public health.
I have... no words.
This is how you destroy science and also public health.
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
Un-fucking-believable.
I have... no words.
This is how you destroy science and also public health.
I have... no words.
This is how you destroy science and also public health.
Reposted by Blurton-Jones Lab
Announcemets on Fridays are meant to fly under the radar. Cutting NIH indirect rates to 15% signal the beginning of the end for a strong US biomedical research enterprise. We need to form strong partnerships with foundations/philantropy and pharma and circle the wagons grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:22 AM
Announcemets on Fridays are meant to fly under the radar. Cutting NIH indirect rates to 15% signal the beginning of the end for a strong US biomedical research enterprise. We need to form strong partnerships with foundations/philantropy and pharma and circle the wagons grants.nih.gov/grants/guide...
Reposted by Blurton-Jones Lab
Cool work the Lance Johnson’s lab on lipid droplet proteome and APOE! @johnsonlab.bsky.social @morganti.bsky.social @cohenlaboratory.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
APOE4 alters the lipid droplet proteome and modulates droplet dynamics
Excess lipid droplet (LD) accumulation is associated with several pathological states, including Alzheimers disease (AD). However, the mechanism(s) by which changes in LD composition and dynamics cont...
www.biorxiv.org
December 22, 2024 at 2:12 PM
Cool work the Lance Johnson’s lab on lipid droplet proteome and APOE! @johnsonlab.bsky.social @morganti.bsky.social @cohenlaboratory.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Blurton-Jones Lab
new preprint!
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
December 21, 2024 at 3:17 PM
new preprint!
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
Reposted by Blurton-Jones Lab
New publication on Cell Reports! We describe a mechanism by which #microglia degrade amyloid-beta deposits that they can't phagocytose.
Collaboration between the Tremblay lab and Rudy Jacquet, Santiago Solé-Domènech and Frederick Maxfield at Weill Cornell.
www.sciencedirect.com/science/arti...
Collaboration between the Tremblay lab and Rudy Jacquet, Santiago Solé-Domènech and Frederick Maxfield at Weill Cornell.
www.sciencedirect.com/science/arti...
Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy
How microglia digest Alzheimer’s fibrillar amyloid-beta (Aβ) plaques that are too large to be phagocytosed is not well understood. Here, we show that …
www.sciencedirect.com
December 9, 2024 at 6:52 PM
New publication on Cell Reports! We describe a mechanism by which #microglia degrade amyloid-beta deposits that they can't phagocytose.
Collaboration between the Tremblay lab and Rudy Jacquet, Santiago Solé-Domènech and Frederick Maxfield at Weill Cornell.
www.sciencedirect.com/science/arti...
Collaboration between the Tremblay lab and Rudy Jacquet, Santiago Solé-Domènech and Frederick Maxfield at Weill Cornell.
www.sciencedirect.com/science/arti...
Reposted by Blurton-Jones Lab
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion https://www.biorxiv.org/content/10.1101/2024.11.18.624173v1
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion https://www.biorxiv.org/content/10.1101/2024.11.18.624173v1
Abnormal lipid metabolism in Alzheimer's disease (AD) was first documented by Alois Alzheimer in his
www.biorxiv.org
November 19, 2024 at 12:08 PM
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion
Reposted by Blurton-Jones Lab
In vivo veritas
"We identify differences in the protein content of ex vivo and in vitro cells and significant proteome differences associated with protein synthesis, metabolism, microglia marker expression, and environmental sensors."
www.cell.com/cell-reports...
"We identify differences in the protein content of ex vivo and in vitro cells and significant proteome differences associated with protein synthesis, metabolism, microglia marker expression, and environmental sensors."
www.cell.com/cell-reports...
Deep proteomic analysis of microglia reveals fundamental biological differences between model systems
Lloyd et al. generated a comprehensive microglia proteome database, identifying over
11,000 proteins. Fundamental differences between ex vivo and in vitro microglia associated
with protein synthesis, ...
www.cell.com
November 22, 2024 at 9:51 PM
In vivo veritas
"We identify differences in the protein content of ex vivo and in vitro cells and significant proteome differences associated with protein synthesis, metabolism, microglia marker expression, and environmental sensors."
www.cell.com/cell-reports...
"We identify differences in the protein content of ex vivo and in vitro cells and significant proteome differences associated with protein synthesis, metabolism, microglia marker expression, and environmental sensors."
www.cell.com/cell-reports...