Haojia Wu
@bluesky.haojia-wu.com
A researcher in #WashU nephrology using computational ways to understand the kidney.
Mastodon: https://mastodon.haojia-wu.com/@haojiawu
GitLab: https://code.haojia-wu.com/users/root/projects
Mastodon: https://mastodon.haojia-wu.com/@haojiawu
GitLab: https://code.haojia-wu.com/users/root/projects
Reposted by Haojia Wu
Another nice prime editing paper in Nature
Prime editing-installed suppressor tRNAs for disease-agnostic genome editing | Nature share.google/JbEgGmuXohSb...
Prime editing-installed suppressor tRNAs for disease-agnostic genome editing | Nature share.google/JbEgGmuXohSb...
Prime editing-installed suppressor tRNAs for disease-agnostic genome editing - Nature
A new strategy that uses prime editing to convert an endogenous tRNA into a suppressor tRNA shows therapeutic potential for multiple genetic diseases that are caused by premature stop codons.
share.google
November 23, 2025 at 9:21 PM
Another nice prime editing paper in Nature
Prime editing-installed suppressor tRNAs for disease-agnostic genome editing | Nature share.google/JbEgGmuXohSb...
Prime editing-installed suppressor tRNAs for disease-agnostic genome editing | Nature share.google/JbEgGmuXohSb...
Universal consensus 3D segmentation of cells from 2D segmented stacks
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Universal consensus 3D segmentation of cells from 2D segmented stacks - Nature Methods
u-Segment3D is a universal framework that translates and enhances 2D instance segmentations to a 3D consensus instance segmentation without training data. It performs well across diverse datasets, inc...
www.nature.com
November 16, 2025 at 10:27 PM
Universal consensus 3D segmentation of cells from 2D segmented stacks
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A unified cell atlas of vascular plants reveals cell-type foundational genes and accelerates gene discovery
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A unified cell atlas of vascular plants reveals cell-type foundational genes and accelerates gene discovery
A cross-species single-cell atlas highlights a core subset of cell-type foundational
genes associated with major vascular plant cell types, enabling the identification
of hidden cell types and the dev...
www.cell.com
October 30, 2025 at 7:40 PM
A unified cell atlas of vascular plants reveals cell-type foundational genes and accelerates gene discovery
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito
A comprehensive single-nucleus RNA-seq atlas of >367,000 nuclei from male and female
Aedes aegypti mosquitoes reveals sexual dimorphism in sensory systems and brain cell
types and widespread co-expres...
www.cell.com
October 30, 2025 at 6:43 PM
A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Sperm sequencing reveals extensive positive selection in the male germline
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
www.nature.com
October 21, 2025 at 6:41 PM
Sperm sequencing reveals extensive positive selection in the male germline
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Haojia Wu
Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells go.nature.com/42wdD05
Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells - Nature Biotechnology
Haploid embryonic stem cells for cattle and sheep are produced, opening new reproductive possibilities.
go.nature.com
October 7, 2025 at 2:28 PM
Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells go.nature.com/42wdD05
RAEFISH - Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
RAEFISH delivers whole-transcriptome (>20,000 genes) imaging at single-molecule resolution
in cells and tissues and enables direct gRNA detection for high-content, image-based
CRISPR screens.
www.cell.com
October 2, 2025 at 11:01 AM
RAEFISH - Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Haojia Wu
Mind blowing mechanotherapy of aged embryo 🤯👹
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 11:01 PM
Mind blowing mechanotherapy of aged embryo 🤯👹
Reposted by Haojia Wu
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
September 28, 2025 at 5:50 PM
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
Reposted by Haojia Wu
The creator of the NumPy and SciPy libraries reflects on their supporting role in the story of Python, now the subject of a documentary
go.nature.com/4gHDSGF
go.nature.com/4gHDSGF
Python, the movie! The programming language’s origin story comes to the silver screen
The creator of the NumPy and SciPy libraries reflects on their supporting role in the story of Python, now the subject of a documentary.
go.nature.com
September 26, 2025 at 10:07 AM
The creator of the NumPy and SciPy libraries reflects on their supporting role in the story of Python, now the subject of a documentary
go.nature.com/4gHDSGF
go.nature.com/4gHDSGF
Reposted by Haojia Wu
🗳️ Election results are in! Join ASN in congratulating Benjamin D. Humphreys, MD, PhD, FASN, as Executive Councilor and Rasheed A. Gbadegesin, MBBS, MD, FASN, as At-Large Councilor. Their terms begin January 1, 2026.
September 25, 2025 at 9:16 PM
🗳️ Election results are in! Join ASN in congratulating Benjamin D. Humphreys, MD, PhD, FASN, as Executive Councilor and Rasheed A. Gbadegesin, MBBS, MD, FASN, as At-Large Councilor. Their terms begin January 1, 2026.
Reposted by Haojia Wu
1. Bluesky doesn’t downrank links
2. You can choose your own algorithm from among thousands
3. The whole app is open source
This keeps it a free and open platform by design, leading to better click-throughs and traffic to your site.
We 💙 the open web.
2. You can choose your own algorithm from among thousands
3. The whole app is open source
This keeps it a free and open platform by design, leading to better click-throughs and traffic to your site.
We 💙 the open web.
September 21, 2025 at 12:08 PM
1. Bluesky doesn’t downrank links
2. You can choose your own algorithm from among thousands
3. The whole app is open source
This keeps it a free and open platform by design, leading to better click-throughs and traffic to your site.
We 💙 the open web.
2. You can choose your own algorithm from among thousands
3. The whole app is open source
This keeps it a free and open platform by design, leading to better click-throughs and traffic to your site.
We 💙 the open web.
Reposted by Haojia Wu
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
September 18, 2025 at 4:14 PM
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
Reposted by Haojia Wu
A large consortium of researchers introduces the term 'translon' to denote any transcriptome region that is decoded by ribosomes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Translon: a single term for translated regions - Nature Methods
Nature Methods - Translon: a single term for translated regions
www.nature.com
September 5, 2025 at 1:30 PM
A large consortium of researchers introduces the term 'translon' to denote any transcriptome region that is decoded by ribosomes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Haojia Wu
A prototype of bifocal eyeglasses uses liquid crystals and electric fields to switch between modes that aid in nearby and distance vision
Liquid crystal lenses could make better bifocal glasses
A prototype of bifocal eyeglasses uses liquid crystals and electric fields to switch between modes that aid in nearby and distance vision
www.newscientist.com
September 5, 2025 at 12:35 AM
A prototype of bifocal eyeglasses uses liquid crystals and electric fields to switch between modes that aid in nearby and distance vision
Stereoseq v2 works on ffpe samples
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution
Stereo-seq V2 facilitates single-cell-resolution spatial RNA mapping in FFPE samples
through random primer capture, uncovering ncRNAs, host-pathogen transcriptome profiling,
and spatial immune reperto...
www.cell.com
August 29, 2025 at 10:35 AM
Stereoseq v2 works on ffpe samples
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Haojia Wu
Target sequence-conditioned design of peptide binders using masked language modeling - @pranam.bsky.social go.nature.com/3UtVc7N
Target sequence-conditioned design of peptide binders using masked language modeling - Nature Biotechnology
PepMLM designs peptide binders against diverse targets using masked language modeling.
go.nature.com
August 13, 2025 at 3:28 PM
Target sequence-conditioned design of peptide binders using masked language modeling - @pranam.bsky.social go.nature.com/3UtVc7N
www.nature.com/articles/s41...
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues - Nature Methods
This work presents MAPIT-seq, an antibody-guided RNA editing method that enables co-profiling of RBP-RNA interactions and gene expression at single-cell resolution and in tissue contexts.
www.nature.com
August 11, 2025 at 1:56 PM
www.nature.com/articles/s41...
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues
Reposted by Haojia Wu
Reposted by Haojia Wu
Just out in @science.org
Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...
Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...
Silencing mitochondrial gene expression in living cells
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central mechanis...
www.science.org
August 1, 2025 at 10:36 AM
Just out in @science.org
Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...
Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...
Reposted by Haojia Wu
Two papers in today's issue of @nature.com : 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.
Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
tinyurl.com
July 23, 2025 at 3:12 PM
Two papers in today's issue of @nature.com : 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.
Reposted by Haojia Wu
📢ONLINE @natgenet.nature.com
📰Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy.
By Jie Liu, @kellybolton.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy.
By Jie Liu, @kellybolton.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy - Nature Genetics
The relationship between pathogenic germline variation, clonal hematopoiesis (CH) and risk of hematologic malignancy is explored in 731,835 individuals across 6 cohorts. Carriers of variants in certai...
www.nature.com
July 16, 2025 at 1:44 PM
📢ONLINE @natgenet.nature.com
📰Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy.
By Jie Liu, @kellybolton.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy.
By Jie Liu, @kellybolton.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Topological velocity inference from spatial transcriptomic data
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Topological velocity inference from spatial transcriptomic data - Nature Biotechnology
TopoVelo infers cell differentiation stages and rate parameters of gene expression using spatially coupled differential equations.
www.nature.com
July 16, 2025 at 1:56 PM
Topological velocity inference from spatial transcriptomic data
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Haojia Wu
📢ONLINE @natgenet.nature.com
📰Single-cell and spatial transcriptomics of stricturing #Crohn’s disease highlights a fibrosis-associated network.
By Lingjia Kong, @thexavierlab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Single-cell and spatial transcriptomics of stricturing #Crohn’s disease highlights a fibrosis-associated network.
By Lingjia Kong, @thexavierlab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network - Nature Genetics
Single-cell and spatial transcriptomics analysis of stricturing Crohn’s disease highlights cellular heterogeneity in fibrotic tissue and identifies neighborhoods of fibroblasts and immune cells contri...
www.nature.com
June 27, 2025 at 2:29 PM
📢ONLINE @natgenet.nature.com
📰Single-cell and spatial transcriptomics of stricturing #Crohn’s disease highlights a fibrosis-associated network.
By Lingjia Kong, @thexavierlab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Single-cell and spatial transcriptomics of stricturing #Crohn’s disease highlights a fibrosis-associated network.
By Lingjia Kong, @thexavierlab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...