Ben Fry
@benf549.bsky.social
PhD Candidate @ Harvard Biophysics Program
ML for Small-Molecule Binding Protein Design
Polizzi Lab at Dana Farber Cancer Institute
🏳️🌈
ML for Small-Molecule Binding Protein Design
Polizzi Lab at Dana Farber Cancer Institute
🏳️🌈
Trying out the Boltz-2 affinity prediction on the Exatecan binders we generated with LASErMPNN and NISE. Affinity prediction still clearly has room to improve, but the model seems to be able to identify the highest affinity mutant in this small dataset. Thanks to @gcorso.bsky.social and team! 1/2
June 7, 2025 at 12:22 AM
Trying out the Boltz-2 affinity prediction on the Exatecan binders we generated with LASErMPNN and NISE. Affinity prediction still clearly has room to improve, but the model seems to be able to identify the highest affinity mutant in this small dataset. Thanks to @gcorso.bsky.social and team! 1/2