Philippe Bastin's Lab
@bastinlab.bsky.social
Research unit @Institut Pasteur & @Inserm dealing with trypanosomes, cilia and flagella, tsetse flies, intraflagellar transport, imaging by light and electron microscopy,...
https://research.pasteur.fr/en/team/trypanosome-cell-biology/
https://research.pasteur.fr/en/team/trypanosome-cell-biology/
Reposted by Philippe Bastin's Lab
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications
Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...
www.nature.com
November 14, 2025 at 8:07 PM
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Exciting project!
Hello mosquito 🦟 and microbiota 🧫 🦠 aficionados, we are looking for a postdoc to join our team (Saleh's lab @salehlabparis.bsky.social at Institut Pasteur @pasteur.fr ) to investigate the interplay between the mosquito, its microbiota, and arboviruses. More information here 👇
November 7, 2025 at 11:10 AM
Exciting project!
Reposted by Philippe Bastin's Lab
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
journals.biologists.com
November 3, 2025 at 5:32 PM
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
A full house for the brilliant talk of Jean Popovici (Institut Pasteur du Cambodge) @pasteur.fr bridging #parasitology and #virology #malaria #plasmodium #Pasteur2030
November 4, 2025 at 7:43 AM
A full house for the brilliant talk of Jean Popovici (Institut Pasteur du Cambodge) @pasteur.fr bridging #parasitology and #virology #malaria #plasmodium #Pasteur2030
Reposted by Philippe Bastin's Lab
Miao Gui and I wrote a Review for the @jcellsci.bsky.social special issue “Cilia and Flagella: From Basic Biology to Disease”. It provides a comprehensive and up-to-date overview of MIP structure, function, and the latest tools used to study them, crafted to serve both newcomers and experts.
a man stands in front of a white board with the words keep that in mind written on it
ALT: a man stands in front of a white board with the words keep that in mind written on it
media.tenor.com
November 3, 2025 at 5:19 AM
Miao Gui and I wrote a Review for the @jcellsci.bsky.social special issue “Cilia and Flagella: From Basic Biology to Disease”. It provides a comprehensive and up-to-date overview of MIP structure, function, and the latest tools used to study them, crafted to serve both newcomers and experts.
Reposted by Philippe Bastin's Lab
📣 Here it is — our overview on ciliary proteomics! Great discussions and writing with @mick-lab.bsky.social and Ronald Roepman 🙏🙏
Hope we didn’t miss anything important - apologies if we did!
#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social
tinyurl.com/yc8ztn5v
Hope we didn’t miss anything important - apologies if we did!
#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social
tinyurl.com/yc8ztn5v
Advances in ciliary proteomics – towards cracking the hidden proteome code of cilia
Summary: This Review explores proteomic strategies for investigating cilia, tracing the evolution from early discoveries to recent advancements enabled by proximity labeling techniques.
journals.biologists.com
November 1, 2025 at 4:34 PM
📣 Here it is — our overview on ciliary proteomics! Great discussions and writing with @mick-lab.bsky.social and Ronald Roepman 🙏🙏
Hope we didn’t miss anything important - apologies if we did!
#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social
tinyurl.com/yc8ztn5v
Hope we didn’t miss anything important - apologies if we did!
#cilia #ciliopathies #proteomics
@theracilproject.bsky.social @for5547.bsky.social
tinyurl.com/yc8ztn5v
Reposted by Philippe Bastin's Lab
One of the ‘Cell Scientists to Watch’ from our #JCSciliaSI is Girish Ram Mali @dyneinassembly.bsky.social @dunnschool.bsky.social. In this interview we learn about Girish’s career path, scientific mentorship, and how science is a human endeavour.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
October 30, 2025 at 4:36 PM
One of the ‘Cell Scientists to Watch’ from our #JCSciliaSI is Girish Ram Mali @dyneinassembly.bsky.social @dunnschool.bsky.social. In this interview we learn about Girish’s career path, scientific mentorship, and how science is a human endeavour.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Daniel's interview!
Read more about this research in our ‘First person’ interview with Daniel Abbühl: journals.biologists.com/jcs/article/...
#JCSciliaSI
#JCSciliaSI
October 29, 2025 at 12:21 PM
Daniel's interview!
Great issue! Bonus: includes Daniel's work on incorporation of tagged tubulin in flagella!
October 28, 2025 at 8:55 AM
Great issue! Bonus: includes Daniel's work on incorporation of tagged tubulin in flagella!
Reposted by Philippe Bastin's Lab
Multiple so called "quality control checks" by the journal almost killed us. - But now it is out!
A novel mito. protein import factor is only essential in T. brucei without kDNA. – Check it out.
Congrats, to the first authors Corinne and Salome and to all our coauthors.
doi.org/10.1111/febs...
A novel mito. protein import factor is only essential in T. brucei without kDNA. – Check it out.
Congrats, to the first authors Corinne and Salome and to all our coauthors.
doi.org/10.1111/febs...
FEBS Press
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we ...
doi.org
October 23, 2025 at 6:27 PM
Multiple so called "quality control checks" by the journal almost killed us. - But now it is out!
A novel mito. protein import factor is only essential in T. brucei without kDNA. – Check it out.
Congrats, to the first authors Corinne and Salome and to all our coauthors.
doi.org/10.1111/febs...
A novel mito. protein import factor is only essential in T. brucei without kDNA. – Check it out.
Congrats, to the first authors Corinne and Salome and to all our coauthors.
doi.org/10.1111/febs...
Reposted by Philippe Bastin's Lab
#holobiont parasite: from descriptive studies towards experimental and clinical tangible evidence that parasites are not alone and that it matters!
Upon virus discovery, we showed an association between fluke-borne virus specific IgG titer and avidity and disease severity.
doi.org/10.1101/2025...
Upon virus discovery, we showed an association between fluke-borne virus specific IgG titer and avidity and disease severity.
doi.org/10.1101/2025...
October 23, 2025 at 4:17 AM
#holobiont parasite: from descriptive studies towards experimental and clinical tangible evidence that parasites are not alone and that it matters!
Upon virus discovery, we showed an association between fluke-borne virus specific IgG titer and avidity and disease severity.
doi.org/10.1101/2025...
Upon virus discovery, we showed an association between fluke-borne virus specific IgG titer and avidity and disease severity.
doi.org/10.1101/2025...
Reposted by Philippe Bastin's Lab
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
October 21, 2025 at 6:11 PM
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
Reposted by Philippe Bastin's Lab
Thank you to the organizers of the CFC meeting 2025 in Oberbronn! See you next year in Lyon! @club-cfc.bsky.social
October 15, 2025 at 2:03 PM
Thank you to the organizers of the CFC meeting 2025 in Oberbronn! See you next year in Lyon! @club-cfc.bsky.social
Special thanks to our keynote lectures for fantastic talks! @micromotility.bsky.social @mick-lab.bsky.social
October 21, 2025 at 11:39 AM
Special thanks to our keynote lectures for fantastic talks! @micromotility.bsky.social @mick-lab.bsky.social
Many thanks to all participants to the CFC2025 meeting last week for having made it such a vibrant experience! So much exciting research on #cilia
October 21, 2025 at 11:35 AM
Many thanks to all participants to the CFC2025 meeting last week for having made it such a vibrant experience! So much exciting research on #cilia
Reposted by Philippe Bastin's Lab
Thank you @bastinlab.bsky.social and Sylvie Friant for organising this amazing #cilia meeting! 🙏 So many interesting discussions, and not enough time! Just look at this beautiful venue... 🤩
October 15, 2025 at 8:07 PM
Thank you @bastinlab.bsky.social and Sylvie Friant for organising this amazing #cilia meeting! 🙏 So many interesting discussions, and not enough time! Just look at this beautiful venue... 🤩
Reposted by Philippe Bastin's Lab
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
The Matthews Lab | Biology
The Matthews Lab
biology.ed.ac.uk
October 17, 2025 at 12:06 PM
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
Reposted by Philippe Bastin's Lab
Soutenez la science qui agit et toutes les équipes de recherche de l’institut @pasteur.fr ! #PasteurDon
Pour chaque vie, la science agit.
Le Pasteurdon, c’est maintenant !
Soutenez la recherche et celles et ceux qui la font avancer ↘️ pasteurdon.fr
#Pasteurdon
Le Pasteurdon, c’est maintenant !
Soutenez la recherche et celles et ceux qui la font avancer ↘️ pasteurdon.fr
#Pasteurdon
October 8, 2025 at 10:11 AM
Soutenez la science qui agit et toutes les équipes de recherche de l’institut @pasteur.fr ! #PasteurDon
Reposted by Philippe Bastin's Lab
Les inscriptions pour la campagne ATIP-Avenir 2026 ouvrent aujourd'hui !
Toutes les informations ici ⬇️
Toutes les informations ici ⬇️
La campagne 2026 ATIP-Avenir est ouverte ! Issu d'un partenariat entre l'Inserm et le @cnrs.fr, ce programme permet à de jeunes chercheurs de constituer leur propre équipe de recherche en sciences de la vie et de la santé.
Inscriptions dès le 3 octobre 2025 : pro.inserm.fr/rubriques/ap...
Inscriptions dès le 3 octobre 2025 : pro.inserm.fr/rubriques/ap...
Atip-Avenir 2026
Vous souhaitez démarrer votre équipe de recherche et porter des projets de haut niveau, ambitieux et novateurs ? L'Inserm et le CNRS vous soutiennent pendant cinq ans.
pro.inserm.fr
October 3, 2025 at 9:03 AM
Les inscriptions pour la campagne ATIP-Avenir 2026 ouvrent aujourd'hui !
Toutes les informations ici ⬇️
Toutes les informations ici ⬇️
Reposted by Philippe Bastin's Lab
Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved and that includes 🫵
October 1, 2025 at 3:51 PM
Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved and that includes 🫵
Reposted by Philippe Bastin's Lab
🔬Fascinated by the unique mitochondrial biology that keeps deadly parasites alive?
🥼We have a fully funded NorthWestBio PhD just for you‼️
🌎 @blslancasteruni.bsky.social
📍Co-supervisor Kostas Tokatlidis @uofglasgow.bsky.social
⏰Deadline 21st Nov
📮Info and to apply👇
www.gla.ac.uk/postgraduate...
🥼We have a fully funded NorthWestBio PhD just for you‼️
🌎 @blslancasteruni.bsky.social
📍Co-supervisor Kostas Tokatlidis @uofglasgow.bsky.social
⏰Deadline 21st Nov
📮Info and to apply👇
www.gla.ac.uk/postgraduate...
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Caroline Dewar
www.gla.ac.uk
October 1, 2025 at 2:57 PM
🔬Fascinated by the unique mitochondrial biology that keeps deadly parasites alive?
🥼We have a fully funded NorthWestBio PhD just for you‼️
🌎 @blslancasteruni.bsky.social
📍Co-supervisor Kostas Tokatlidis @uofglasgow.bsky.social
⏰Deadline 21st Nov
📮Info and to apply👇
www.gla.ac.uk/postgraduate...
🥼We have a fully funded NorthWestBio PhD just for you‼️
🌎 @blslancasteruni.bsky.social
📍Co-supervisor Kostas Tokatlidis @uofglasgow.bsky.social
⏰Deadline 21st Nov
📮Info and to apply👇
www.gla.ac.uk/postgraduate...
Congratulations to Brice @gloverlab.bsky.social and the whole team for a great piece of work!
SHERLOCK4HAT: a CRISPR-RNA test rapidly spots animal trypanosomes, boosting sleeping-sickness surveillance and protecting herds. Led by Institut Pasteur & partners, study in eLife.
Details: www.pasteur.fr/en/home/rese...
Details: www.pasteur.fr/en/home/rese...
September 24, 2025 at 7:46 AM
Congratulations to Brice @gloverlab.bsky.social and the whole team for a great piece of work!
Outstanding work from Prof Hiroshi Hamada @ncbsbangalore.bsky.social on the contribution of cilia to the definition of left-right asymmetry in multiple organisms, fascinating data on snails. Many thanks to @meilhacsigolene.bsky.social for the organisation @pasteur.fr @institutimagine.bsky.social
September 24, 2025 at 6:56 AM
Outstanding work from Prof Hiroshi Hamada @ncbsbangalore.bsky.social on the contribution of cilia to the definition of left-right asymmetry in multiple organisms, fascinating data on snails. Many thanks to @meilhacsigolene.bsky.social for the organisation @pasteur.fr @institutimagine.bsky.social
Reposted by Philippe Bastin's Lab
Brazil hopes to turn the tide of dengue with a home-grown vaccine and an army of mosquitoes
go.nature.com/41VWT1V
go.nature.com/41VWT1V
How billions of hacked mosquitoes and a vaccine could beat the deadly dengue virus
Outbreaks of dengue are killing thousands of people in South America each year and getting worse. Brazil hopes to turn the tide with a home-grown vaccine and an army of mosquitoes infected with Wolbachia bacteria.
go.nature.com
September 16, 2025 at 12:20 PM
Brazil hopes to turn the tide of dengue with a home-grown vaccine and an army of mosquitoes
go.nature.com/41VWT1V
go.nature.com/41VWT1V
