Atin Sharma
@atinsharma.bsky.social
Associate editor at Nature Microbiology.
I read your microbiome papers!
All opinions are personal
🇩🇪🇸🇪🇮🇳
I read your microbiome papers!
All opinions are personal
🇩🇪🇸🇪🇮🇳
Reposted by Atin Sharma
The findings of a study in Nature Medicine introduce microbial elements as a component of the brain tumor microenvironment and lay the foundation for future mechanistic and translational studies. go.nature.com/44bO314 #medsky #microbiome 🧪
November 21, 2025 at 11:35 PM
The findings of a study in Nature Medicine introduce microbial elements as a component of the brain tumor microenvironment and lay the foundation for future mechanistic and translational studies. go.nature.com/44bO314 #medsky #microbiome 🧪
Reposted by Atin Sharma
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 18, 2025 at 2:07 PM
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
Reposted by Atin Sharma
Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 18, 2025 at 2:26 PM
Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model
My dog is realising how I feel on a cold rainy day.
November 18, 2025 at 6:37 PM
My dog is realising how I feel on a cold rainy day.
Reposted by Atin Sharma
#NewResearch
A preclinical study finds that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against lung and nasal infection with Bordetella pertussis
www.nature.com/articles/s41...
A preclinical study finds that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against lung and nasal infection with Bordetella pertussis
www.nature.com/articles/s41...
Respiratory immunization using antibiotic-inactivated Bordetella pertussis confers T cell-mediated protection against nasal infection in mice - Nature Microbiology
In this preclinical study, the authors find that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that p...
www.nature.com
November 11, 2025 at 3:48 PM
#NewResearch
A preclinical study finds that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against lung and nasal infection with Bordetella pertussis
www.nature.com/articles/s41...
A preclinical study finds that respiratory immunization with an antibiotic-treated bacterial vaccine is a highly effective approach for inducing tissue-resident memory T cells that protect against lung and nasal infection with Bordetella pertussis
www.nature.com/articles/s41...
Reposted by Atin Sharma
#NewResearch
Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding
#MicroSky #CRISPR 🦠
www.nature.com/articles/s41...
Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding
#MicroSky #CRISPR 🦠
www.nature.com/articles/s41...
A phage-encoded anti-CRISPR protein co-opts host enolase to prevent type III CRISPR immunity - Nature Microbiology
Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding.
www.nature.com
November 11, 2025 at 3:49 PM
#NewResearch
Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding
#MicroSky #CRISPR 🦠
www.nature.com/articles/s41...
Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding
#MicroSky #CRISPR 🦠
www.nature.com/articles/s41...
Reposted by Atin Sharma
Hi everyone, a few years ago, we started a list of labs studying bacterial immunty for students, editors, conference organizers... (currently n=79).
Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky #Microsky
Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky #Microsky
Labs in bacterial immunity
docs.google.com
November 4, 2025 at 3:06 PM
Hi everyone, a few years ago, we started a list of labs studying bacterial immunty for students, editors, conference organizers... (currently n=79).
Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky #Microsky
Update time ! Send me a message to 1) add your lab or others 2) Correct info
docs.google.com/spreadsheets...
#Phagesky #Microsky
Reposted by Atin Sharma
New online! Gut virome dynamics: from commensal to critical player in health and disease
Gut virome dynamics: from commensal to critical player in health and disease
Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01134-zThe gut virome is a complex ecosystem and has a critical role in human health. This Review outlines gut virome composition and functional relevance, and its role in human health and disease. Methodological challenges in advancing our knowledge of the gut virome are also discussed.
www.nature.com
November 5, 2025 at 12:30 PM
New online! Gut virome dynamics: from commensal to critical player in health and disease
Reposted by Atin Sharma
Having a PhD means you can find the word “unfortunately” in an email faster that the search function
October 28, 2025 at 3:58 AM
Having a PhD means you can find the word “unfortunately” in an email faster that the search function
Reposted by Atin Sharma
Paper alert! Proud to share our latest publication @natmicrobiol.nature.com #mycosky
#NewResearch
Despite being a virulence factor, candidalysin toxin is essential for Candida albicans to penetrate the oral epithelium to establish non-infectious colonisation.
@lableibundgut.bsky.social @frois-martins.bsky.social
@leibniz-hki.de
#MicroSky 🍄
www.nature.com/articles/s41...
Despite being a virulence factor, candidalysin toxin is essential for Candida albicans to penetrate the oral epithelium to establish non-infectious colonisation.
@lableibundgut.bsky.social @frois-martins.bsky.social
@leibniz-hki.de
#MicroSky 🍄
www.nature.com/articles/s41...
Dynamic expression of candidalysin facilitates oral colonization of Candida albicans in mice - Nature Microbiology
Despite being a virulence factor, candidalysin toxin is essential for Candida albicans to penetrate the oral epithelium to establish and maintain non-infectious colonization
www.nature.com
October 1, 2025 at 7:11 PM
Paper alert! Proud to share our latest publication @natmicrobiol.nature.com #mycosky
Last week I found myself surrounded by brilliant researchers and talking about their exciting research at #ESSMicrobiome @events.embl.org
If you missed talking to me, just a reminder that The Clinical Microbiome collection is still open for submissions!
www.nature.com/collections/...
If you missed talking to me, just a reminder that The Clinical Microbiome collection is still open for submissions!
www.nature.com/collections/...
The Clinical Microbiome
This joint Collection invites submissions of cutting-edge translational and clinical research, including microbiome-based diagnostics, therapeutics, ...
www.nature.com
September 22, 2025 at 3:19 PM
Last week I found myself surrounded by brilliant researchers and talking about their exciting research at #ESSMicrobiome @events.embl.org
If you missed talking to me, just a reminder that The Clinical Microbiome collection is still open for submissions!
www.nature.com/collections/...
If you missed talking to me, just a reminder that The Clinical Microbiome collection is still open for submissions!
www.nature.com/collections/...
So many cool presentations and so many new potential papers!
If you want to discuss your future paper in Nature Microbiology, don't forget to catch me around!
#EESMicrobiome #MicrobiomeSky
If you want to discuss your future paper in Nature Microbiology, don't forget to catch me around!
#EESMicrobiome #MicrobiomeSky
I will be at #EESMicrobiome hosted by @events.embl.org from tomorrow.
Looking forward to meeting brilliant people and learning about their exciting research.
If you catch me around, do talk to me about publishing in Nature Microbiology.
#MicrobiomeSky #MicroSky
Looking forward to meeting brilliant people and learning about their exciting research.
If you catch me around, do talk to me about publishing in Nature Microbiology.
#MicrobiomeSky #MicroSky
September 18, 2025 at 11:27 AM
So many cool presentations and so many new potential papers!
If you want to discuss your future paper in Nature Microbiology, don't forget to catch me around!
#EESMicrobiome #MicrobiomeSky
If you want to discuss your future paper in Nature Microbiology, don't forget to catch me around!
#EESMicrobiome #MicrobiomeSky
I will be at #EESMicrobiome hosted by @events.embl.org from tomorrow.
Looking forward to meeting brilliant people and learning about their exciting research.
If you catch me around, do talk to me about publishing in Nature Microbiology.
#MicrobiomeSky #MicroSky
Looking forward to meeting brilliant people and learning about their exciting research.
If you catch me around, do talk to me about publishing in Nature Microbiology.
#MicrobiomeSky #MicroSky
September 15, 2025 at 2:05 PM
I will be at #EESMicrobiome hosted by @events.embl.org from tomorrow.
Looking forward to meeting brilliant people and learning about their exciting research.
If you catch me around, do talk to me about publishing in Nature Microbiology.
#MicrobiomeSky #MicroSky
Looking forward to meeting brilliant people and learning about their exciting research.
If you catch me around, do talk to me about publishing in Nature Microbiology.
#MicrobiomeSky #MicroSky
Reposted by Atin Sharma
We are looking for a postdoc to study single-cell transcriptional heterogeneity in the human skin microbiome.
We have a new protocol mostly developed, but need someone to see it through. Experience with protocol dev or RNAseq appreciated.
Funded by a new grant from MIT-HEALS.
We have a new protocol mostly developed, but need someone to see it through. Experience with protocol dev or RNAseq appreciated.
Funded by a new grant from MIT-HEALS.
September 12, 2025 at 4:49 PM
We are looking for a postdoc to study single-cell transcriptional heterogeneity in the human skin microbiome.
We have a new protocol mostly developed, but need someone to see it through. Experience with protocol dev or RNAseq appreciated.
Funded by a new grant from MIT-HEALS.
We have a new protocol mostly developed, but need someone to see it through. Experience with protocol dev or RNAseq appreciated.
Funded by a new grant from MIT-HEALS.
Reposted by Atin Sharma
The multi-kingdom cancer microbiome. #Cancer #Microbiome @natmicrobiol.nature.com 🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 13, 2025 at 7:32 AM
The multi-kingdom cancer microbiome. #Cancer #Microbiome @natmicrobiol.nature.com 🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Why do some manuscripts get a decision faster than the others?
Here is a quick guide to help you bridge the gap and get a faster primary evaluation.
#editorome #AcademicChatter #AcademicSky
open.substack.com/pub/editorom...
Here is a quick guide to help you bridge the gap and get a faster primary evaluation.
#editorome #AcademicChatter #AcademicSky
open.substack.com/pub/editorom...
Passing the editorial hurdle quickly
How to make your manuscript get a faster decision by an editor
open.substack.com
September 14, 2025 at 3:19 PM
Why do some manuscripts get a decision faster than the others?
Here is a quick guide to help you bridge the gap and get a faster primary evaluation.
#editorome #AcademicChatter #AcademicSky
open.substack.com/pub/editorom...
Here is a quick guide to help you bridge the gap and get a faster primary evaluation.
#editorome #AcademicChatter #AcademicSky
open.substack.com/pub/editorom...
Reposted by Atin Sharma
Super cool Pseudomonas-Bacillus interaction paper in @natmicrobiol.nature.com from Yun Chen
with @gabrieleberg.bsky.social
Phenazines shape Gram+ abundance & influence Bacillus cell biology
Phenazines contribute to microbiome dynamics by targeting topoisomerase IV
www.nature.com/articles/s41...
with @gabrieleberg.bsky.social
Phenazines shape Gram+ abundance & influence Bacillus cell biology
Phenazines contribute to microbiome dynamics by targeting topoisomerase IV
www.nature.com/articles/s41...
September 11, 2025 at 2:04 PM
Super cool Pseudomonas-Bacillus interaction paper in @natmicrobiol.nature.com from Yun Chen
with @gabrieleberg.bsky.social
Phenazines shape Gram+ abundance & influence Bacillus cell biology
Phenazines contribute to microbiome dynamics by targeting topoisomerase IV
www.nature.com/articles/s41...
with @gabrieleberg.bsky.social
Phenazines shape Gram+ abundance & influence Bacillus cell biology
Phenazines contribute to microbiome dynamics by targeting topoisomerase IV
www.nature.com/articles/s41...
Reposted by Atin Sharma
Nature research paper: Commensal yeast promotes Salmonella Typhimurium virulence
go.nature.com/4mTnRzG
go.nature.com/4mTnRzG
Commensal yeast promotes Salmonella Typhimurium virulence - Nature
Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.
go.nature.com
September 5, 2025 at 3:19 PM
Nature research paper: Commensal yeast promotes Salmonella Typhimurium virulence
go.nature.com/4mTnRzG
go.nature.com/4mTnRzG
Reposted by Atin Sharma
Nature research paper: A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2
go.nature.com/4mZHupC
go.nature.com/4mZHupC
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 - Nature
A neutralizing nanobody specific to the prefusion conformation of herpes simplex virus glycoprotein B has cross-species activity and offers insights into virus neutralization, possible immunogens and an attractive avenue for antiviral interventions.
go.nature.com
September 9, 2025 at 1:24 PM
Nature research paper: A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2
go.nature.com/4mZHupC
go.nature.com/4mZHupC
I started a little weekend project because clearly reading and writing during the weekdays was not enough for me! 😄
Please take a look and share some feedback!
editorome.substack.com
#MicroSky #MicrobiomeSky 🦠
Please take a look and share some feedback!
editorome.substack.com
#MicroSky #MicrobiomeSky 🦠
editorome | Atin Sharma | Substack
A microbiology editor sharing microbiology things. Click to read editorome, by Atin Sharma, a Substack publication. Launched 6 days ago.
editorome.substack.com
September 6, 2025 at 12:26 PM
I started a little weekend project because clearly reading and writing during the weekdays was not enough for me! 😄
Please take a look and share some feedback!
editorome.substack.com
#MicroSky #MicrobiomeSky 🦠
Please take a look and share some feedback!
editorome.substack.com
#MicroSky #MicrobiomeSky 🦠
Reposted by Atin Sharma
Excited to share our new publication, out today in Nature! www.nature.com/articles/s41.... @kanchanj.bsky.social led this fascinating fungal-bacterial interaction project. We are grateful for our wonderful collaborators Brian Peters and David Underhill.
Commensal yeast promotes Salmonella Typhimurium virulence - Nature
Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.
www.nature.com
September 3, 2025 at 4:32 PM
Excited to share our new publication, out today in Nature! www.nature.com/articles/s41.... @kanchanj.bsky.social led this fascinating fungal-bacterial interaction project. We are grateful for our wonderful collaborators Brian Peters and David Underhill.
Reposted by Atin Sharma
Savour the fine flavour of our September issue, featuring...
〰️Bacterial prions in phage defence
💊Antibiotics from archaea
🔺Spike complexes in Sabiá, Junin and Machupo viruses
🛡️Aggresomes and mRNA protection
🤝A call for early-career teams
...and more, here 👇
www.nature.com/nmicrobiol/v...
〰️Bacterial prions in phage defence
💊Antibiotics from archaea
🔺Spike complexes in Sabiá, Junin and Machupo viruses
🛡️Aggresomes and mRNA protection
🤝A call for early-career teams
...and more, here 👇
www.nature.com/nmicrobiol/v...
September 3, 2025 at 5:50 PM
Savour the fine flavour of our September issue, featuring...
〰️Bacterial prions in phage defence
💊Antibiotics from archaea
🔺Spike complexes in Sabiá, Junin and Machupo viruses
🛡️Aggresomes and mRNA protection
🤝A call for early-career teams
...and more, here 👇
www.nature.com/nmicrobiol/v...
〰️Bacterial prions in phage defence
💊Antibiotics from archaea
🔺Spike complexes in Sabiá, Junin and Machupo viruses
🛡️Aggresomes and mRNA protection
🤝A call for early-career teams
...and more, here 👇
www.nature.com/nmicrobiol/v...
September 3, 2025 at 6:59 PM
Reposted by Atin Sharma
A Nature Outlook article reports on the preliminary evidence that microbiota-based treatments can be beneficial for people with mood disorders, such as depression and anxiety. But how these interventions work is not clear, and human trials are needed. #microbiome #medsky 🧪
Why nurturing the gut microbiota could resolve depression and anxiety
Links between gut microbes and mental health could lead to large-scale trials of probiotic interventions.
go.nature.com
August 31, 2025 at 1:05 PM
A Nature Outlook article reports on the preliminary evidence that microbiota-based treatments can be beneficial for people with mood disorders, such as depression and anxiety. But how these interventions work is not clear, and human trials are needed. #microbiome #medsky 🧪