@asmitasingh.bsky.social
Reposted
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
October 31, 2025 at 6:24 AM
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
Reposted
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair www.biorxiv.org/content/10.1...
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
www.biorxiv.org
October 26, 2025 at 3:04 PM
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair www.biorxiv.org/content/10.1...
Reposted
UNC Core Facility Technology Talks
Monday, October 20, 2025 | 1 - 4 PM
Join us in 3112 Mary Ellen Jones building or virtually.
@oor-unc.bsky.social
www.med.unc.edu/corefaciliti...
Monday, October 20, 2025 | 1 - 4 PM
Join us in 3112 Mary Ellen Jones building or virtually.
@oor-unc.bsky.social
www.med.unc.edu/corefaciliti...
October 15, 2025 at 6:59 PM
UNC Core Facility Technology Talks
Monday, October 20, 2025 | 1 - 4 PM
Join us in 3112 Mary Ellen Jones building or virtually.
@oor-unc.bsky.social
www.med.unc.edu/corefaciliti...
Monday, October 20, 2025 | 1 - 4 PM
Join us in 3112 Mary Ellen Jones building or virtually.
@oor-unc.bsky.social
www.med.unc.edu/corefaciliti...
Reposted
In memory of Dr. Jane Goodall, we're releasing a special podcast episode today. Ira Flatow shares his memories of the renowned primatologist, including a 2002 interview in which they discussed her groundbreaking discoveries and hopes for a better future.
Remembering Primatologist Jane Goodall
Trailblazing chimp researcher and conservationist Jane Goodall died on October 1 at 91.
www.sciencefriday.com
October 2, 2025 at 4:46 PM
In memory of Dr. Jane Goodall, we're releasing a special podcast episode today. Ira Flatow shares his memories of the renowned primatologist, including a 2002 interview in which they discussed her groundbreaking discoveries and hopes for a better future.
Reposted
🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉
🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
October 1, 2025 at 4:11 AM
🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉
🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
Reposted
"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C
VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...
journals.plos.org
September 29, 2025 at 1:47 PM
"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...
www.biorxiv.org
September 22, 2025 at 11:23 PM
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Reposted
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 15, 2025 at 6:03 PM
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Reposted
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature
A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...
www.nature.com
September 17, 2025 at 4:18 PM
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Here are the curated lists of pubs in the #PlacentalCellBio
@biomednews.bsky.social report from the last two weeks!
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/
Enjoy!
@biomednews.bsky.social report from the last two weeks!
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/
Enjoy!
Efficient stem cell-derived mouse embryo models for environmental studies - PubMed
Blastoids are stem cell-derived structures that mimic natural blastocysts by incorporating all three lineages: trophectoderm, epiblast, and primitive endoderm. However, current methods often yield inc...
pubmed.ncbi.nlm.nih.gov
September 14, 2025 at 3:23 PM
Here are the curated lists of pubs in the #PlacentalCellBio
@biomednews.bsky.social report from the last two weeks!
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/
Enjoy!
@biomednews.bsky.social report from the last two weeks!
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/
Enjoy!
Reposted
Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!
Liver-specific loss of Atg9a perturbs lipid metabolism and hepatocyte integrity
The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional At...
doi.org
September 3, 2025 at 4:56 PM
Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!
Reposted
Differential inclusion formation of an aggregation-prone protein reveals differences in the proteostasis capacity of neuronal cell lines https://www.biorxiv.org/content/10.1101/2025.08.26.672484v1
August 29, 2025 at 10:30 PM
Differential inclusion formation of an aggregation-prone protein reveals differences in the proteostasis capacity of neuronal cell lines https://www.biorxiv.org/content/10.1101/2025.08.26.672484v1
Reposted
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
www.nature.com
August 19, 2025 at 8:57 AM
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Reposted
Working with a great team to organize @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February! Join us to explore emerging research in Keystone! keysym.us/KSAutophagy26 #KSAutophagy26
Autophagy: Mechanisms to Therapy | Keystone Symposia
Join us at the Keystone Symposia on Autophagy: Mechanisms to Therapy, February 2026, in Keystone, with field leaders!
keysym.us
August 15, 2025 at 1:31 PM
Working with a great team to organize @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February! Join us to explore emerging research in Keystone! keysym.us/KSAutophagy26 #KSAutophagy26
Reposted
Toxic PFAS from firefighting foam contaminated a town’s water supply for decades. Now, early data from a CDC-led study is illuminating the forever chemicals’ effects on its residents.
How PFAS From A Military Base Has Sickened Nearby Residents
Newburgh, New York, is one of 10 communities involved in a CDC-led study to understand the effects of PFAS—forever chemicals—on health.
www.sciencefriday.com
July 12, 2025 at 4:04 PM
Toxic PFAS from firefighting foam contaminated a town’s water supply for decades. Now, early data from a CDC-led study is illuminating the forever chemicals’ effects on its residents.
Check out this fantastic Review from the @charlyguardia.bsky.social lab!!
Our new review on placental peptide hormone secretion is out! Our two postbacs, Sadia and Mayra, did an excellent job summarizing a lot of (sometimes) conflincting data!
www.frontiersin.org/journals/end...
www.frontiersin.org/journals/end...
Frontiers | Secretion of placental peptide hormones: functions and trafficking
The placenta is a dynamic endocrine organ that plays a crucial role in fetal development by secreting a diverse array of peptide hormones that regulate mater...
www.frontiersin.org
June 22, 2025 at 11:48 PM
Check out this fantastic Review from the @charlyguardia.bsky.social lab!!
Very interesting!!!!!
Nature research paper: Maternal iron deficiency causes male-to-female sex reversal in mouse embryos
https://go.nature.com/45fG1G1
https://go.nature.com/45fG1G1
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos - Nature
Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.
go.nature.com
June 6, 2025 at 1:57 AM
Very interesting!!!!!
Reposted
A little glimpse into our lab at NIEHS/NIH! 👋🏽
Guardia Studies Role of Environmental Stressors on Fetal Development
NIH's Dr. Carlos Guardia studies the placenta. He and his team strive to understand the effects of maternal obesity and other environmental stressors on the future health of the baby.
nihrecord.nih.gov
May 9, 2025 at 1:07 PM
A little glimpse into our lab at NIEHS/NIH! 👋🏽
Reposted
new out in Nature, very cool story www.nature.com/articles/s41...
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
www.nature.com
May 7, 2025 at 3:48 PM
new out in Nature, very cool story www.nature.com/articles/s41...
Reposted
Structural basis of lipid transfer by a bridge-like lipid-transfer protein pubmed.ncbi.nlm.nih.gov/40269155/ #cryoem
April 26, 2025 at 4:38 AM
Structural basis of lipid transfer by a bridge-like lipid-transfer protein pubmed.ncbi.nlm.nih.gov/40269155/ #cryoem
Reposted
Mouse egg cells stash endosomes, lysosomes, and autophagy regulators in giant structures called ELYSAs. After fertilisation, they break down, timing the embryo’s cleanup and recycling systems for early development.
buff.ly/aM5oMxt
buff.ly/aM5oMxt
April 20, 2025 at 1:59 PM
Mouse egg cells stash endosomes, lysosomes, and autophagy regulators in giant structures called ELYSAs. After fertilisation, they break down, timing the embryo’s cleanup and recycling systems for early development.
buff.ly/aM5oMxt
buff.ly/aM5oMxt