Dr. Arun Sethuraman
@arunsethuraman.bsky.social
Computational evolutionary biologist. Associate Professor at @sandiegostate.bsky.social, athlete, insomniac, writer, singer, polyglot, polymath. He/him. 🏳️🌈🇮🇳🇺🇸🐞🌱🐢🧬🏋🏾♂️🎤✍🏾 www.sethuramanlab.com Views are mine and mine alone.
Pinned
Hi Bluesky community - I'm teaching computational genomics again in the Spring term; always happy to have auditors or folks Zoom in. Just have your students email me for deets.
The kind of nonsensical cruelty this is - the only ‘public charge’ is the government that’s extorting money (visa applications and interviews are expensive, and if denied, non refundable). Also, folks cant travel into the US without proof of insurance anyway. apple.news/AF-ki4EYTSdC...
Immigrants with obesity, diabetes and other health problems may be denied visas — NPR
New guidance from the Trump administration directs visa officers to consider common health ailments, including obesity and diabetes, when would-be immigrants seek to enter the U.S.
apple.news
November 13, 2025 at 1:12 PM
The kind of nonsensical cruelty this is - the only ‘public charge’ is the government that’s extorting money (visa applications and interviews are expensive, and if denied, non refundable). Also, folks cant travel into the US without proof of insurance anyway. apple.news/AF-ki4EYTSdC...
I feel like I spend half my life arguing with angry HPC admins who complain that our files are too big/we're filling up the nodes. Dude that's exactly why we pay 100s of 1000s of $ to purchase nodes and file systems!! Not for them to just sit around.
a gray and white cat is sitting on the floor looking at the camera .
ALT: a gray and white cat is sitting on the floor looking at the camera .
media.tenor.com
November 12, 2025 at 5:42 PM
I feel like I spend half my life arguing with angry HPC admins who complain that our files are too big/we're filling up the nodes. Dude that's exactly why we pay 100s of 1000s of $ to purchase nodes and file systems!! Not for them to just sit around.
Reposted by Dr. Arun Sethuraman
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen - Nature Communications
In this study, the authors analysed a large genomic dataset to trace how jumping genes shaped the global spread of a major wheat pathogen and reveal bursts of activity over decades that drove adaptati...
www.nature.com
November 12, 2025 at 1:17 PM
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Hi Bluesky community - I'm teaching computational genomics again in the Spring term; always happy to have auditors or folks Zoom in. Just have your students email me for deets.
November 11, 2025 at 10:19 PM
Hi Bluesky community - I'm teaching computational genomics again in the Spring term; always happy to have auditors or folks Zoom in. Just have your students email me for deets.
Reposted by Dr. Arun Sethuraman
Our latest story in preprint (www.biorxiv.org/content/10.1...) and one of my favorites so far. More detailed thread to come. Tldr we show that the distinctive collagen patterning we see in black breast cancer patients is caused by tumor intrinsic signaling and is critical for metastasis 1/3 🧪
November 11, 2025 at 12:49 AM
Our latest story in preprint (www.biorxiv.org/content/10.1...) and one of my favorites so far. More detailed thread to come. Tldr we show that the distinctive collagen patterning we see in black breast cancer patients is caused by tumor intrinsic signaling and is critical for metastasis 1/3 🧪
Reposted by Dr. Arun Sethuraman
New research from #ProcB: Confounding Fuels Misinterpretation in Human Genetics royalsocietypublishing.org/doi/10.1098/... | #Behaviour #Evolution #Genomics
November 9, 2025 at 2:01 PM
New research from #ProcB: Confounding Fuels Misinterpretation in Human Genetics royalsocietypublishing.org/doi/10.1098/... | #Behaviour #Evolution #Genomics
Reposted by Dr. Arun Sethuraman
Phylogeny of tinamous based on whole-genomes and fossils: academic.oup.com/sysbio/advan... 🪶🧪 (📷Musher et al.)
November 7, 2025 at 2:22 PM
Phylogeny of tinamous based on whole-genomes and fossils: academic.oup.com/sysbio/advan... 🪶🧪 (📷Musher et al.)
Reposted by Dr. Arun Sethuraman
Amy Angert and I are recruiting a #postdoc to participate in a collaborative NSF-funded study of demographic responses to climate across the geographic range of the scarlet monkeyflower. Please repost! jobs.ncsu.edu/postings/224...
November 7, 2025 at 3:10 PM
Amy Angert and I are recruiting a #postdoc to participate in a collaborative NSF-funded study of demographic responses to climate across the geographic range of the scarlet monkeyflower. Please repost! jobs.ncsu.edu/postings/224...
Reposted by Dr. Arun Sethuraman
On the cover of our #LatestIssue: Photo of a Joshua #tree (Yucca jaegeriana) at dawn in the Mojave #Desert. Image courtesy of Karolina Heyduk.
📖 See Heyduk et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
📖 See Heyduk et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
November 6, 2025 at 10:15 AM
On the cover of our #LatestIssue: Photo of a Joshua #tree (Yucca jaegeriana) at dawn in the Mojave #Desert. Image courtesy of Karolina Heyduk.
📖 See Heyduk et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
📖 See Heyduk et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
Lol @ Gayle King on CBS Mornings, commenting on this: ‘I’m glad that Dr. Oz was there - I’m sure he knew what to do’ 😹
This is officially one of the strangest pictures in American history, and I do not doubt that it will be considered iconic a hundred years from now.
100% serious here.
100% serious here.
November 7, 2025 at 3:32 PM
Lol @ Gayle King on CBS Mornings, commenting on this: ‘I’m glad that Dr. Oz was there - I’m sure he knew what to do’ 😹
Re-upping this! Do join us today at noon pacific!
Aaaahhh! Stoked to welcome and host the one and only Dr. Dunn this Friday (11/7/25) at noon PST in the @calstate.bsky.social bioinformatics webinar series! Do join us via Zoom: sdsu.zoom.us/j/88624423158
November 7, 2025 at 3:12 PM
Re-upping this! Do join us today at noon pacific!
Reposted by Dr. Arun Sethuraman
How is functional variation at large-effect loci maintained in natural populations, even as environments change? In a paper led by @mkarag.bsky.social, we tracked known pesticide resistant alleles in outdoor 𝘋. 𝘮𝘦𝘭𝘢𝘯𝘰𝘨𝘢𝘴𝘵𝘦𝘳 cages & inferred selection and dominance from temporal sequencing data.
November 6, 2025 at 9:51 PM
How is functional variation at large-effect loci maintained in natural populations, even as environments change? In a paper led by @mkarag.bsky.social, we tracked known pesticide resistant alleles in outdoor 𝘋. 𝘮𝘦𝘭𝘢𝘯𝘰𝘨𝘢𝘴𝘵𝘦𝘳 cages & inferred selection and dominance from temporal sequencing data.
Reposted by Dr. Arun Sethuraman
On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
November 6, 2025 at 9:46 PM
On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
Reposted by Dr. Arun Sethuraman
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
www.nature.com
November 7, 2025 at 12:05 AM
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Congratulations to @doc-brock.bsky.social on advancing her first MS student to candidacy! Such cool work with introduced Italian wall lizards across native and invasive ranges - looking forward to seeing what Alyssa and Dr. Brock will discover!
a person is holding a lizard in their hands
ALT: a person is holding a lizard in their hands
media.tenor.com
November 7, 2025 at 1:49 AM
Congratulations to @doc-brock.bsky.social on advancing her first MS student to candidacy! Such cool work with introduced Italian wall lizards across native and invasive ranges - looking forward to seeing what Alyssa and Dr. Brock will discover!
Reposted by Dr. Arun Sethuraman
Oxygen limitation is considered a key mechanism of #ThermalTolerance. @dianasmadeira.bsky.social explores how a @plosbiology.org study challenges this idea, showing minimal protective effects of O2 supersaturation in heat-stressed #aquatic #ectotherms 🧪 Paper: plos.io/43hzMQa Primer: plos.io/3XeUtbS
November 6, 2025 at 5:30 PM
Oxygen limitation is considered a key mechanism of #ThermalTolerance. @dianasmadeira.bsky.social explores how a @plosbiology.org study challenges this idea, showing minimal protective effects of O2 supersaturation in heat-stressed #aquatic #ectotherms 🧪 Paper: plos.io/43hzMQa Primer: plos.io/3XeUtbS
Reposted by Dr. Arun Sethuraman
New and improved! (as of today, now with page numbers and an issue number ;)
"Evidence for ancient selective sweeps followed by differentiation among three species of Sphyrapicus sapsuckers"
Led by Dr. Libby Natola:
doi.org/10.1093/jeb/...
"Evidence for ancient selective sweeps followed by differentiation among three species of Sphyrapicus sapsuckers"
Led by Dr. Libby Natola:
doi.org/10.1093/jeb/...
Evidence for ancient selective sweeps followed by differentiation among three species of Sphyrapicus sapsuckers
Abstract. Genomic differentiation usually accompanies speciation, but that differentiation is often highly heterogeneous across the genome. Understanding w
doi.org
November 6, 2025 at 6:59 PM
New and improved! (as of today, now with page numbers and an issue number ;)
"Evidence for ancient selective sweeps followed by differentiation among three species of Sphyrapicus sapsuckers"
Led by Dr. Libby Natola:
doi.org/10.1093/jeb/...
"Evidence for ancient selective sweeps followed by differentiation among three species of Sphyrapicus sapsuckers"
Led by Dr. Libby Natola:
doi.org/10.1093/jeb/...
Reposted by Dr. Arun Sethuraman
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
A comparative analysis of transposable element diversity and evolution across 75 bee genomes - BMC Genomics
Transposable elements (TEs) are repetitive DNA sequences that can alter their position and abundance within genomes. While TEs are known to have various impacts on genome structure and function, our u...
doi.org
November 6, 2025 at 1:29 PM
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
Reposted by Dr. Arun Sethuraman
With @aconga.bsky.social we wrote a short Dispatch to highlight two awesome companion papers in @currentbiology.bsky.social by @jeffgroh.bsky.social, @gcbias.bsky.social and by Liu et al. on how the control of heterodichogamy is going nuts in the Juglandaceae :
www.cell.com/current-biol...
www.cell.com/current-biol...
November 5, 2025 at 8:00 AM
With @aconga.bsky.social we wrote a short Dispatch to highlight two awesome companion papers in @currentbiology.bsky.social by @jeffgroh.bsky.social, @gcbias.bsky.social and by Liu et al. on how the control of heterodichogamy is going nuts in the Juglandaceae :
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by Dr. Arun Sethuraman
I am so proud & happy to see our Potamo genome assembly finally out there in the world! The process ended up being way more challenging than expected, but for some really cool reasons. ❤️🐌🧬
TLDR: Surprise! A VERY recent WGD.
academic.oup.com/gbe/article/...
Photo: C. Böck, ILIM, Mondsee, Austria)
TLDR: Surprise! A VERY recent WGD.
academic.oup.com/gbe/article/...
Photo: C. Böck, ILIM, Mondsee, Austria)
November 5, 2025 at 4:50 PM
I am so proud & happy to see our Potamo genome assembly finally out there in the world! The process ended up being way more challenging than expected, but for some really cool reasons. ❤️🐌🧬
TLDR: Surprise! A VERY recent WGD.
academic.oup.com/gbe/article/...
Photo: C. Böck, ILIM, Mondsee, Austria)
TLDR: Surprise! A VERY recent WGD.
academic.oup.com/gbe/article/...
Photo: C. Böck, ILIM, Mondsee, Austria)
New preprint out today from us! Priyanshi built a pipeline to catalog telomeric content across the 1KGP phase 3 dataset, and we test for differences across populations, chromosomes, and sexes. Do check it out! Comments welcome.
A Comprehensive Catalog of Telomere Content Variation Across Human Populations https://www.biorxiv.org/content/10.1101/2025.11.03.686324v1
November 5, 2025 at 2:38 PM
New preprint out today from us! Priyanshi built a pipeline to catalog telomeric content across the 1KGP phase 3 dataset, and we test for differences across populations, chromosomes, and sexes. Do check it out! Comments welcome.
Reposted by Dr. Arun Sethuraman
We’re excited to expand our partnership with @reviewcommons.org in a new collaborative model reshaping scientific publishing to streamline peer review, reduce redundancy, and improve the author and reviewer experience. Read more: buff.ly/h6SfMXF
And meet our Editorial Board! 👋
And meet our Editorial Board! 👋
November 5, 2025 at 2:01 PM
We’re excited to expand our partnership with @reviewcommons.org in a new collaborative model reshaping scientific publishing to streamline peer review, reduce redundancy, and improve the author and reviewer experience. Read more: buff.ly/h6SfMXF
And meet our Editorial Board! 👋
And meet our Editorial Board! 👋
Go get ‘em, California!
JUST IN: California voters have approved a ballot measure to redraw the state's congressional map to favor Democrats, marking the party's biggest victory to date in a national battle over redistricting ahead of the 2026 midterms.
California voters OK new congressional lines, boosting Democrats ahead of midterms
California voters have approved a ballot measure to redraw the state's congressional map to favor Democrats, marking the party's biggest victory to date in a national battle over redistricting ahead of the 2026 midterms.
n.pr
November 5, 2025 at 4:10 AM
Go get ‘em, California!
Extra credit on your pop-gen exam today if you vote! Be a responsible citizen - this country needs it more than ever.
barack obama is giving a speech on a stage and saying `` do n't boo , vote ''
ALT: barack obama is giving a speech on a stage and saying `` do n't boo , vote ''
media.tenor.com
November 4, 2025 at 3:44 PM
Extra credit on your pop-gen exam today if you vote! Be a responsible citizen - this country needs it more than ever.
Reposted by Dr. Arun Sethuraman
Janaki Ammal was born 128 years ago today! A legend of botanical genetics, she studied how polyploidy plays into the resilience of agricultural crops, compiled a sprawling chromosomal atlas of plants, and fought for the preservation of India's natural legacy.
tinyurl.com/2j9hxmjb
#WomenInSTEM
tinyurl.com/2j9hxmjb
#WomenInSTEM
Janaki Ammal And the Fight for India’s Botanical Future.
Caste. Race. Gender. These were the three categories that, in early twentieth century Madras, combined to determine the boundaries of an individual’s potential. Being of an undesirable categorizat...
tinyurl.com
November 4, 2025 at 3:13 PM
Janaki Ammal was born 128 years ago today! A legend of botanical genetics, she studied how polyploidy plays into the resilience of agricultural crops, compiled a sprawling chromosomal atlas of plants, and fought for the preservation of India's natural legacy.
tinyurl.com/2j9hxmjb
#WomenInSTEM
tinyurl.com/2j9hxmjb
#WomenInSTEM