Antiretroviral Therapy for Multiple Sclerosis
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art4ms.bsky.social
Antiretroviral Therapy for Multiple Sclerosis
@art4ms.bsky.social
21 followers 140 following 25 posts
Rationale for Antiretroviral Therapy for Treatment of Multiple Sclerosis art4ms.com #multiplesclerosis #ms #ebv
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art4ms.bsky.social
Antiretroviral Therapy for Multiple Sclerosis @art4ms.bsky.social · 15d
EBV causes Multiple Sclerosis. Evidence indicating that EBV drives MS is growing. If EBV drives MS then elimination of EBV would be a rational therapy. There are licensed drugs with activity against EBV, such as the antiviral tenofovir alafenamide. #multiplesclerosis #ms #ebv

art4ms.com
art4ms.com - Antiretroviral Therapy for Multiple Sclerosis
EBV drives Multiple Sclerosis. Elimination of EBV is a rational therapy for MS. The antiviral medication tenofovir alafenamide inhibits of EBV reactivation.
art4ms.com
Reposted by Antiretroviral Therapy for Multiple Sclerosis
jsabatino37.bsky.social
EBV Dysregulation Is Associated With Immune Imbalance in Multiple Sclerosis

www.neurology.org/doi/10.1212/...
EBV Dysregulation Is Associated With Immune Imbalance in Multiple Sclerosis | Neurology Neuroimmunology & Neuroinflammation
Background and ObjectivesEpstein-Barr virus (EBV) infection is a prerequisite for the development of multiple sclerosis (MS), yet whether EBV acts merely as a trigger at disease onset or also contribu...
www.neurology.org
February 2, 2026 at 12:06 AM
art4ms.bsky.social
EBV causes Multiple Sclerosis. Evidence indicating that EBV drives MS is growing. If EBV drives MS then elimination of EBV would be a rational therapy. There are licensed drugs with activity against EBV, such as the antiviral tenofovir alafenamide. #multiplesclerosis #ms #ebv

art4ms.com
art4ms.com - Antiretroviral Therapy for Multiple Sclerosis
EBV drives Multiple Sclerosis. Elimination of EBV is a rational therapy for MS. The antiviral medication tenofovir alafenamide inhibits of EBV reactivation.
art4ms.com
January 24, 2026 at 11:49 AM
art4ms.bsky.social
See the following dropbox link for a number of scientific papers indicating that EBV is the cause and driver of MS disease activity, and on potential antiviral therapies. #MS #EBV #multiplesclerosis

www.dropbox.com/scl/fo/1qutc...
January 24, 2026 at 11:33 AM
art4ms.bsky.social
3 new reports on the mechanistic underpinnings of multiple sclerosis and Epstein-Barr virus involvement published in Cell

EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation

www.cell.com/cell/fulltex...
EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation
EBV infection alters the transcriptome of B cells, which leads to presentation of MBP peptides on HLA-DR15 molecules. MBP peptide-specific CD4+ T cells are found in the peripheral immune compartment a...
www.cell.com
January 23, 2026 at 10:58 PM
art4ms.bsky.social
The authors of this paper created a list of therapies with anti-EBV effects.

Repurposing Licensed Drugs with Activity Against Epstein-Barr Virus for Treatment of Multiple Sclerosis: A Systematic Approach

pubmed.ncbi.nlm.nih.gov/39792343/

#ebv #ms #multiplesclerosis #ebvcausesmsn#art4ms
Repurposing Licensed Drugs with Activity Against Epstein-Barr Virus for Treatment of Multiple Sclerosis: A Systematic Approach - PubMed
Scientific and lived experience expert panel review of anti-EBV therapies selected four candidates with evidence for efficacy against EBV and acceptable safety and tolerability for potential use in phase III clinical trials for MS.
pubmed.ncbi.nlm.nih.gov
January 23, 2026 at 6:33 PM
art4ms.bsky.social
Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis #ebv #ms #multiplesclerosis #ART4MS #EBVcausesMS

rupress.org/jem/article-...
rupress.org
January 23, 2026 at 3:26 PM
art4ms.bsky.social
#MultipleSclerosis is caused by #EBV. The risk of #MS increased 32-fold after infection with EBV. Serum levels of neurofilament light chain increased only after EBV infection. These findings suggest EBV as the leading cause of MS.

www.science.org/doi/10.1126/...
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Epstein-Barr virus infection precedes symptoms and biomarkers of multiple sclerosis and markedly increases disease risk.
www.science.org
January 23, 2026 at 1:51 PM
art4ms.bsky.social
EBV as the “gluten of MS” hypothesis provides a rationale for trialing antiviral therapies #EBV #MS #multiplesclerosis #EBVcausesMS #ART4MS

www.msard-journal.com/article/S221...
EBV as the “gluten of MS” hypothesis provides a rationale for trialing antiviral therapies
Infection with the Epstein-Barr virus (EBV) has long been established as an environmental factor associated with multiple sclerosis (MS) risk (Thacker et al., 2006, Munger et al., 2011, Levin et al., ...
www.msard-journal.com
January 23, 2026 at 1:49 PM
art4ms.bsky.social
The case for targeting latent and lytic
Epstein-Barr virus infection in multiple sclerosis #ms #ebv #ebvcausesms #multiplesclerosis #art4ms

pmc.ncbi.nlm.nih.gov/articles/PMC...
January 22, 2026 at 5:22 PM
art4ms.bsky.social
There is a reduced risk of developing MS in HIV+ patients taking antiretroviral therapy. There are also several cases of patients who presented indefinite remission or resolution of multiple sclerosis symptoms after induction of ART.
#ms #ebv #multiplesclerosis

link.springer.com/article/10.1...
Human immunodeficiency virus and multiple sclerosis: a review of the literature - Neurological Research and Practice
Multiple sclerosis (MS) and human immunodeficiency virus (HIV) infection are frequent and well-studied nosological entities. Yet, comorbidity of MS and HIV has only been rarely reported in the medical...
link.springer.com
January 22, 2026 at 11:58 AM
art4ms.bsky.social
In the era of antiviral trials for multiple sclerosis the answer lies in the details
#ebv #ms #multiplesclerosis #art4ms #antiviral

www.dropbox.com/scl/fo/1qutc...
January 22, 2026 at 1:40 AM
art4ms.bsky.social
Radiologic and clinical stability in an HIV-negative multiple sclerosis patient after #tenofovir: An updated case report
#MultipleSclerosis #MS #EBV

www.dropbox.com/scl/fo/1qutc...
January 22, 2026 at 1:37 AM
art4ms.bsky.social
HIV infection and multiple sclerosis: a case with unexpected “no evidence of disease activity” status #multiplesclerosis #ms #antiviral #ebv #antiretroviral #taf #tenofovir

journals.sagepub.com/doi/full/10....
HIV infection and multiple sclerosis: a case with unexpected “no evidence of disease activity” status - Fernando Labella, Fernando Acebrón, María del Carmen Blanco-Valero, Alba Rodrígez-Martín, Ángela...
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system whose etiology remains unclear. It has been suggested that MS can...
journals.sagepub.com
January 21, 2026 at 4:43 PM
art4ms.bsky.social
Tenofovir as a treatment option for multiple sclerosis

www.sciencedirect.com/science/arti...

#MS #EBV #MultipleSclerosis
Tenofovir as a treatment option for multiple sclerosis
Some antiretroviral medications are also inhibitors of EBV. We describe a patient with highly active MS who was infected with HIV and started HIV-trea…
www.sciencedirect.com
January 21, 2026 at 11:50 AM
Reposted by Antiretroviral Therapy for Multiple Sclerosis
gavingiovannoni.bsky.social
#MS_Selfie Newsletter - Necessary, but insufficient

Getting naysayers to understand and accept “EBV is necessary, but insufficient to develop MS” is important, as they often review and reject grant applications. And ..... => buff.ly/8rCPzQJ
Necessary, but insufficient
Getting naysayers to understand and accept “EBV is necessary, but insufficient to develop MS” is important, as they often review and reject grant applications. And .....
gavingiovannoni.substack.com
January 13, 2026 at 10:12 AM
art4ms.bsky.social
Tenofovir prodrugs potently inhibit Epstein–Barr virus lytic DNA replication by targeting the viral DNA polymerase
#EBV #MS #MultipleSclerosis #antivirals #ARTMS #ART4MS

www.pnas.org/doi/10.1073/...
January 20, 2026 at 11:50 PM
art4ms.bsky.social
The below chart has important implications regarding TAF dose. Fig 5G indicates that the standard dose of TAF would reach a concentration needed to block 40% of DNA replication (EC40) mediated by the EBV polymerase after 40 min in their in vitro assay.

www.pnas.org/doi/10.1073/...

#ms #ebv
January 20, 2026 at 11:48 PM
art4ms.bsky.social
Tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF), are both tenofovir prodrugs that improve the absorption and delivery of tenofovir, which gets converted into its active form inside cells to stop viral replication #multiplesclerosis #ebv #ms

www.descovyhcp.com/taf-pharmaco...
January 20, 2026 at 11:45 PM
art4ms.bsky.social
Tenofovir disoproxil fumerate TDF at 300mg daily has been used for PrEP for over a decade. This may indicate that doses of tenofovir alafenamide fumerate TAF greater than 25mg are safe long term, however this needs further study. #PrEP #MultipleSclerosis #EBV
January 20, 2026 at 10:01 PM
art4ms.bsky.social
Below are clinical trials looking at tenofovir for treatment of Multiple Sclerosis. #EBV #antiretroviral #MS #antiviral art4ms.com

clinicaltrials.gov/study/NCT059...

mstrials.org.au/fatigue-in-r...

www.helse-bergen.no/en/neuro-sys...
art4ms.com - Antiretroviral Therapy for Multiple Sclerosis
EBV drives Multiple Sclerosis. Elimination of EBV is a rational therapy for MS. The antiviral medication tenofovir alafenamide inhibits of EBV reactivation.
art4ms.com
January 20, 2026 at 9:42 PM
art4ms.bsky.social
EBV causes Multiple Sclerosis. Evidence indicating that EBV drives MS is growing. If EBV is drives MS then elimination of EBV would be a rational therapy. There are licensed drugs with activity against EBV, such as the antiviral tenofovir alafenamide. #multiplesclerosis #ms #ebv

art4ms.com
art4ms.com - Antiretroviral Therapy for Multiple Sclerosis
EBV drives Multiple Sclerosis. Elimination of EBV is a rational therapy for MS. The antiviral medication tenofovir alafenamide inhibits of EBV reactivation.
art4ms.com
January 20, 2026 at 9:27 PM