This is game changer!!

Spatial multi-omics reveals cell-type-specific nuclear compartments

Two-layer DNA seqFISH+
Simultaneous mapping of 100,049 genomic loci
+ nascent transcriptome for 17,856 genes in single cells

www.nature.com/articles/s41...

It was great to visit IIT-Kanpur and Delhi University his week and interact with colleagues Amit Dutt, Hamim Zafar, Arun Shukla, Ananda, Santosh and others.. discussing common grounds between developmental biology and cancer.. also an opportunity to revisit old memories of undergrad days..

I’ll be speaking at DU south campus and talking about our recent work. Thank you Amit Dutt for kind invitation. This is an special for me as 20 years ago I did my first internship as undergraduate at DU Genetics dept which ignited my interest in genome biology 🧬

Five months into new gig! Here we are building world class team in Oncofetal research at Garvan Institute! We are looking for a computational biologist with proven track record in spatial biology, if you are keen to explore neighbourhoods drop a text :)

Generalized cell phenotyping for spatial proteomics with language-informed vision models
www.biorxiv.org/content/10.1...

Eavesdropping on Notch-Delta chatter at endothelia-fibroblast niche #HCC #Xenium

Excited to share our updated Renoir @biorxivpreprint.bsky.social with Hamim from IITK to predict spatial cell-cell interactions
New additions:
- Benchmarking data
- Applicability on SMI (CosMx) data
- Identification of stem-like MUC6 cancer cells in oncofetal niche
www.biorxiv.org/content/10.1...

#ecosystem in action #xenium @10xgenomics.bsky.social #Liver

Very interesting work showing Hepatocellular senescence results in senescence and dysfunction in other organs
www.nature.com/articles/s41...

Navigating the mutation maze: An oncogenic driver’s guide to macrophage reprogramming
Here we write a preview of James Ross and Dolores Hambardzumyan's recent publication in Immunity
Article: www.cell.com/immunity/ful...
Preview: www.cell.com/immunity/ful...