Andreas Schaefer
@andreas-t-schaefer.bsky.social
Neuroscientist @crick.ac.uk asking how information is processed in the brain.
Odours. Circuits. Neurotechnology. Synchrotrons. BCIs.
Co-founder Paradromics
Twitter: @AndreasTSchafer
Odours. Circuits. Neurotechnology. Synchrotrons. BCIs.
Co-founder Paradromics
Twitter: @AndreasTSchafer
Pinned
My PhD project is out as a preprint!
We combined 2P and synchrotron X-ray to understand mouse olfactory bulb circuits, linking physiology to structure in 3 animals!
doi.org/10.1101/2025...
🙌 @carlesbosch.bsky.social, @apacureanu.bsky.social, @andreas-t-schaefer.bsky.social, @esrf.fr, @crick.ac.uk
We combined 2P and synchrotron X-ray to understand mouse olfactory bulb circuits, linking physiology to structure in 3 animals!
doi.org/10.1101/2025...
🙌 @carlesbosch.bsky.social, @apacureanu.bsky.social, @andreas-t-schaefer.bsky.social, @esrf.fr, @crick.ac.uk
Linking function and structure at scale with X-rays - and several times over. Massive congratulations to the team @yuxinzhang.bsky.social, @carlesbosch.bsky.social, @apacureanu.bsky.social @esrf.fr, @crick.ac.uk and all our collaborators.
Bit more than 2 weeks to go...
DM me if you will be in San Diego at SfN and want to talk about it. Please share.
DM me if you will be in San Diego at SfN and want to talk about it. Please share.
The Crick is an absolutely amazing place to work in - please share this opportunity widely with your colleagues and postdocs - and DM me if I can help in any way
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
November 9, 2025 at 2:30 PM
Bit more than 2 weeks to go...
DM me if you will be in San Diego at SfN and want to talk about it. Please share.
DM me if you will be in San Diego at SfN and want to talk about it. Please share.
Very excited to continue our amazing collaboration with @apacureanu.bsky.social at @esrf.fr - thank you @wellcometrust.bsky.social and all the collaborators at @crick.ac.uk and @esrf.fr
Congratulations to @andreas-t-schaefer.bsky.social on receiving a £3.8 million @wellcometrust.bsky.social Discovery Award, working with @esrf.fr, to chart the brain circuity behind the sense of smell in mice.
www.crick.ac.uk/news/2025-10...
www.crick.ac.uk/news/2025-10...
New £3.8m project to map the mouse olfactory system
Andreas Schaefer, Principal Group Leader of the Sensory Circuits and Neurotechnology Laboratory at the Crick, has received a Wellcome Discovery Award to chart the brain circuitry behind the sense of s...
www.crick.ac.uk
November 2, 2025 at 9:21 PM
Very excited to continue our amazing collaboration with @apacureanu.bsky.social at @esrf.fr - thank you @wellcometrust.bsky.social and all the collaborators at @crick.ac.uk and @esrf.fr
The Crick is an absolutely amazing place to work in - please share this opportunity widely with your colleagues and postdocs - and DM me if I can help in any way
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 3:00 PM
The Crick is an absolutely amazing place to work in - please share this opportunity widely with your colleagues and postdocs - and DM me if I can help in any way
Judging by the last ones, this will be amazing - and with all the new developments at next gen synchrotrons, even more timely. Please re-post, join in person if you can travel to London or via zoom
Join us *next Monday*!
#CrickXrays25
X-ray #nanoimaging of biological tissues
🇬🇧🌐 @crick.ac.uk & online
tinyurl.com/crickxrays25
Sponsored by @dectris.bsky.social, @webknossos.org and @biologists.bsky.social and backed by @brukercorporation.bsky.social and Histomography
#CrickXrays25
X-ray #nanoimaging of biological tissues
🇬🇧🌐 @crick.ac.uk & online
tinyurl.com/crickxrays25
Sponsored by @dectris.bsky.social, @webknossos.org and @biologists.bsky.social and backed by @brukercorporation.bsky.social and Histomography
October 7, 2025 at 9:26 AM
Judging by the last ones, this will be amazing - and with all the new developments at next gen synchrotrons, even more timely. Please re-post, join in person if you can travel to London or via zoom
Reposted by Andreas Schaefer
Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
www.crick.ac.uk
October 2, 2025 at 12:53 PM
Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Reposted by Andreas Schaefer
The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠
I'm looking for people who are excited about developing multimodal analysis and visualization tools to capture the "hidden connectome," in a highly intersectional environment exploring ideas in meta-science.
mrc.tal.net/vx/mobile-0/...
I'm looking for people who are excited about developing multimodal analysis and visualization tools to capture the "hidden connectome," in a highly intersectional environment exploring ideas in meta-science.
mrc.tal.net/vx/mobile-0/...
Imaging Data Engineer - Neurobiology - Dr Sven Truckenbrodt - LMB 2697 - Medical Research Council
Location: Cambridge. Vacancy: Imaging Data Engineer - Neurobiology - Dr Sven Truckenbrodt - LMB 2697. Closing Date: 09/10/2025, 23:55
mrc.tal.net
September 22, 2025 at 8:12 AM
The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠
I'm looking for people who are excited about developing multimodal analysis and visualization tools to capture the "hidden connectome," in a highly intersectional environment exploring ideas in meta-science.
mrc.tal.net/vx/mobile-0/...
I'm looking for people who are excited about developing multimodal analysis and visualization tools to capture the "hidden connectome," in a highly intersectional environment exploring ideas in meta-science.
mrc.tal.net/vx/mobile-0/...
Lots of exciting clinical PhD projects at Crick - including the opportunity for neurosurgeons to work with us and record electrical activity in patients with neuropixels probes. Please share widely!
We're looking for clinicians who are passionate about research to join our 3-year fully funded clinical PhD programme. 🔬🩺
Apply by 14 November 2025. 👇
www.crick.ac.uk/careers-stud...
Apply by 14 November 2025. 👇
www.crick.ac.uk/careers-stud...
Doctoral clinical fellows
The Crick's clinical PhD programme.
www.crick.ac.uk
October 1, 2025 at 10:08 AM
Lots of exciting clinical PhD projects at Crick - including the opportunity for neurosurgeons to work with us and record electrical activity in patients with neuropixels probes. Please share widely!
Great opportunity to work with an amazing team on the frontiers of X-ray connectomics www.psi.ch/en/hr/job-op...
Postdoctoral Fellow on high-throughput X-ray laminography
The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting-edge research in the fields of future technologies, energy...
www.psi.ch
September 25, 2025 at 11:15 AM
Great opportunity to work with an amazing team on the frontiers of X-ray connectomics www.psi.ch/en/hr/job-op...
Reposted by Andreas Schaefer
Applications are now open for the SWC Systems Neuroscience PhD Programme.
Join us in London!
🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social
Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
Join us in London!
🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social
Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
September 23, 2025 at 8:47 AM
Applications are now open for the SWC Systems Neuroscience PhD Programme.
Join us in London!
🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social
Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
Join us in London!
🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social
Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
Reposted by Andreas Schaefer
#preprint:
We optimised the preparation of tissues for #X-ray phase contrast imaging.
Drying tissue samples (instead of embedding them) brings more signal in #X-ray phase contrast images.
The process largely preserves #ultrastructure.
@safekhan.bsky.social @andreas-t-schaefer.bsky.social
We optimised the preparation of tissues for #X-ray phase contrast imaging.
Drying tissue samples (instead of embedding them) brings more signal in #X-ray phase contrast images.
The process largely preserves #ultrastructure.
@safekhan.bsky.social @andreas-t-schaefer.bsky.social
Our pre-print is out!
Critical point drying of brain tissue for x-ray phase contrast imaging.
@apeart.bsky.social @yuxinzhang.bsky.social @jkbrmn.bsky.social @apacureanu.bsky.social @andreas-t-schaefer.bsky.social
@carlesbosch.bsky.social
@esrf.fr
@crick.ac.uk
bioarXiv: doi.org/10.1101/2025...
Critical point drying of brain tissue for x-ray phase contrast imaging.
@apeart.bsky.social @yuxinzhang.bsky.social @jkbrmn.bsky.social @apacureanu.bsky.social @andreas-t-schaefer.bsky.social
@carlesbosch.bsky.social
@esrf.fr
@crick.ac.uk
bioarXiv: doi.org/10.1101/2025...
Critical point drying of brain tissue for X-ray phase contrast imaging
X-ray phase contrast tomography is emerging as a powerful method for imaging large volumes of brain tissue at sub-cellular resolution. However, current sample preparation methods are largely inherited...
doi.org
September 10, 2025 at 3:51 PM
#preprint:
We optimised the preparation of tissues for #X-ray phase contrast imaging.
Drying tissue samples (instead of embedding them) brings more signal in #X-ray phase contrast images.
The process largely preserves #ultrastructure.
@safekhan.bsky.social @andreas-t-schaefer.bsky.social
We optimised the preparation of tissues for #X-ray phase contrast imaging.
Drying tissue samples (instead of embedding them) brings more signal in #X-ray phase contrast images.
The process largely preserves #ultrastructure.
@safekhan.bsky.social @andreas-t-schaefer.bsky.social
Reposted by Andreas Schaefer
Our pre-print is out!
Critical point drying of brain tissue for x-ray phase contrast imaging.
@apeart.bsky.social @yuxinzhang.bsky.social @jkbrmn.bsky.social @apacureanu.bsky.social @andreas-t-schaefer.bsky.social
@carlesbosch.bsky.social
@esrf.fr
@crick.ac.uk
bioarXiv: doi.org/10.1101/2025...
Critical point drying of brain tissue for x-ray phase contrast imaging.
@apeart.bsky.social @yuxinzhang.bsky.social @jkbrmn.bsky.social @apacureanu.bsky.social @andreas-t-schaefer.bsky.social
@carlesbosch.bsky.social
@esrf.fr
@crick.ac.uk
bioarXiv: doi.org/10.1101/2025...
Critical point drying of brain tissue for X-ray phase contrast imaging
X-ray phase contrast tomography is emerging as a powerful method for imaging large volumes of brain tissue at sub-cellular resolution. However, current sample preparation methods are largely inherited...
doi.org
September 10, 2025 at 3:19 PM
Our pre-print is out!
Critical point drying of brain tissue for x-ray phase contrast imaging.
@apeart.bsky.social @yuxinzhang.bsky.social @jkbrmn.bsky.social @apacureanu.bsky.social @andreas-t-schaefer.bsky.social
@carlesbosch.bsky.social
@esrf.fr
@crick.ac.uk
bioarXiv: doi.org/10.1101/2025...
Critical point drying of brain tissue for x-ray phase contrast imaging.
@apeart.bsky.social @yuxinzhang.bsky.social @jkbrmn.bsky.social @apacureanu.bsky.social @andreas-t-schaefer.bsky.social
@carlesbosch.bsky.social
@esrf.fr
@crick.ac.uk
bioarXiv: doi.org/10.1101/2025...
Reposted by Andreas Schaefer
We are looking for an IT engineer with a focus on operations and research data management at the Centre for Organismal Studies at @uniheidelberg in Heidelberg, Germany
#it #sysadmin #linux #researchdata
please help to spread this opening […]
[Original post on biologists.social]
#it #sysadmin #linux #researchdata
please help to spread this opening […]
[Original post on biologists.social]
September 1, 2025 at 8:58 AM
We are looking for an IT engineer with a focus on operations and research data management at the Centre for Organismal Studies at @uniheidelberg in Heidelberg, Germany
#it #sysadmin #linux #researchdata
please help to spread this opening […]
[Original post on biologists.social]
#it #sysadmin #linux #researchdata
please help to spread this opening […]
[Original post on biologists.social]
Reposted by Andreas Schaefer
We watched mice follow scent trails drawn on an “endless” treadmill. By manipulating trail geometry/statistics, perturbing mouse nose & brain, and modeling behavior with a Bayesian framework, we show that mice use predictive (rather than reactive) strategies.
September 1, 2025 at 7:07 PM
We watched mice follow scent trails drawn on an “endless” treadmill. By manipulating trail geometry/statistics, perturbing mouse nose & brain, and modeling behavior with a Bayesian framework, we show that mice use predictive (rather than reactive) strategies.
Reposted by Andreas Schaefer
And we are off - excited that #cns2025florence is under way with record attendance - first keynote starts in 5 minutes.
July 5, 2025 at 2:08 PM
And we are off - excited that #cns2025florence is under way with record attendance - first keynote starts in 5 minutes.
Reposted by Andreas Schaefer
Scary. Authors building in hidden instructions for presumed LLM peer reviewers (in white text on white background).
White text on white background instructing LLMs to give positive reviews is apparently now common enough to show up in searches for boilerplate text.
"in 2025 we will have flying cars" 😂😂😂
July 5, 2025 at 8:47 PM
Scary. Authors building in hidden instructions for presumed LLM peer reviewers (in white text on white background).
Reposted by Andreas Schaefer
Clinical research in England is wild! 3+ years, 20+ meetings, 200+ documents, 500+ emails is what it can take to open a fully funded, observational non-CTIMP study.
Thank you @chrischirp.bsky.social and colleagues for calling attention to this urgent, solvable crisis!
www.bmj.com/content/390/...
Thank you @chrischirp.bsky.social and colleagues for calling attention to this urgent, solvable crisis!
www.bmj.com/content/390/...
Health research in England is grinding to a halt
Wes Streeting, the UK health and social care secretary, announced in 2024 that “the NHS is broken” against a background of ballooning waiting lists, delays in disease detection, and reduced staff prod...
www.bmj.com
July 6, 2025 at 10:00 AM
Clinical research in England is wild! 3+ years, 20+ meetings, 200+ documents, 500+ emails is what it can take to open a fully funded, observational non-CTIMP study.
Thank you @chrischirp.bsky.social and colleagues for calling attention to this urgent, solvable crisis!
www.bmj.com/content/390/...
Thank you @chrischirp.bsky.social and colleagues for calling attention to this urgent, solvable crisis!
www.bmj.com/content/390/...
Reposted by Andreas Schaefer
We wrote a little #NeuroAI piece about in-context learning & neural dynamics vs. continual learning & plasticity, both mechanisms to flexibly adapt to changing environments:
arxiv.org/abs/2507.02103
We relate this to non-stationary rule learning tasks with rapid performance jumps.
Feedback welcome!
arxiv.org/abs/2507.02103
We relate this to non-stationary rule learning tasks with rapid performance jumps.
Feedback welcome!
What Neuroscience Can Teach AI About Learning in Continuously Changing Environments
Modern AI models, such as large language models, are usually trained once on a huge corpus of data, potentially fine-tuned for a specific task, and then deployed with fixed parameters. Their training ...
arxiv.org
July 6, 2025 at 10:18 AM
We wrote a little #NeuroAI piece about in-context learning & neural dynamics vs. continual learning & plasticity, both mechanisms to flexibly adapt to changing environments:
arxiv.org/abs/2507.02103
We relate this to non-stationary rule learning tasks with rapid performance jumps.
Feedback welcome!
arxiv.org/abs/2507.02103
We relate this to non-stationary rule learning tasks with rapid performance jumps.
Feedback welcome!
Reposted by Andreas Schaefer
Great thread, showing how even the most educated people need humility to accept what they dont’t know. That’s the way you will learn.
A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH.
The importance of feeling responsibility and taking pride in doing the best job you can
The importance of feeling responsibility and taking pride in doing the best job you can
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
July 6, 2025 at 1:00 PM
Great thread, showing how even the most educated people need humility to accept what they dont’t know. That’s the way you will learn.
Reposted by Andreas Schaefer
🏊 Serotonin controls how hard a zebrafish swims as changes in its body or environment effect its effort. Now, researchers are uncovering how neurons figure out when & how much serotonin to secrete – providing new insights into neuromodulation ➡️ www.janelia.org/news/new-res...
July 6, 2025 at 1:55 PM
🏊 Serotonin controls how hard a zebrafish swims as changes in its body or environment effect its effort. Now, researchers are uncovering how neurons figure out when & how much serotonin to secrete – providing new insights into neuromodulation ➡️ www.janelia.org/news/new-res...
Reposted by Andreas Schaefer
Tomorrow the second Behavioral Neurobiology Summer School in Collaboration with the Pristina International Summer University will start at University of Pristina, Kosovo!! Thank you Ilir Mazreku for having us over for a visit from Konstanz! Thank you Flutura Shabani for all the organization!
July 6, 2025 at 9:24 PM
Tomorrow the second Behavioral Neurobiology Summer School in Collaboration with the Pristina International Summer University will start at University of Pristina, Kosovo!! Thank you Ilir Mazreku for having us over for a visit from Konstanz! Thank you Flutura Shabani for all the organization!
Reposted by Andreas Schaefer
🧵 It's #ResearchAppreciationDay! 🔬 🧪 🧬
Time to shout out our brilliant UCL researchers changing lives daily!
Here are just a few of our top research stories of 2025:
Time to shout out our brilliant UCL researchers changing lives daily!
Here are just a few of our top research stories of 2025:
July 5, 2025 at 10:08 AM
🧵 It's #ResearchAppreciationDay! 🔬 🧪 🧬
Time to shout out our brilliant UCL researchers changing lives daily!
Here are just a few of our top research stories of 2025:
Time to shout out our brilliant UCL researchers changing lives daily!
Here are just a few of our top research stories of 2025:
Reposted by Andreas Schaefer
Here is your last reminder that the application deadline for Imbizo.Africa is nearing quickly, the 1st of July, in fact tomorrow. Still the place where diversity is at its best in the world! Tell all who need to hear. #africa #neuro
#Imbizo - Simons Computational Neuroscience Imbizo - #Imbizo
Simons Computational Neuroscience Imbizo summer school in Cape Town, South Africa
Imbizo.Africa
June 30, 2025 at 7:53 PM
Here is your last reminder that the application deadline for Imbizo.Africa is nearing quickly, the 1st of July, in fact tomorrow. Still the place where diversity is at its best in the world! Tell all who need to hear. #africa #neuro
Reposted by Andreas Schaefer
Crick researchers have shown that the ‘pacemaker’ controlling yeast cell division is located inside the nucleus, rather than outside it as was previously thought.
This research was led by @nitinkapadia.bsky.social and Paul Nurse.
www.crick.ac.uk/news/2025-06...
This research was led by @nitinkapadia.bsky.social and Paul Nurse.
www.crick.ac.uk/news/2025-06...
Researchers show that the cell nucleus is the pacemaker for cell division
Researchers at the Francis Crick Institute have shown that the 'pacemaker' controlling yeast cell division lies inside the nucleus rather than outside it, as previously thought. Having the pacemaker i...
www.crick.ac.uk
June 25, 2025 at 3:55 PM
Crick researchers have shown that the ‘pacemaker’ controlling yeast cell division is located inside the nucleus, rather than outside it as was previously thought.
This research was led by @nitinkapadia.bsky.social and Paul Nurse.
www.crick.ac.uk/news/2025-06...
This research was led by @nitinkapadia.bsky.social and Paul Nurse.
www.crick.ac.uk/news/2025-06...
Reposted by Andreas Schaefer
Researchers at the Crick and UCL have developed laboratory models of dementia, including Alzheimer's, to show that certain genetic messages are misplaced in diseased nerve cells.
The finding could offer a potential target for new treatments for neurodegeneration.
www.crick.ac.uk/news/2025-06...
The finding could offer a potential target for new treatments for neurodegeneration.
www.crick.ac.uk/news/2025-06...
Researchers identify lost genetic messages as a target for treating dementia
Researchers at the Francis Crick Institute and UCL have shown that genetic messages are misplaced in nerve cells in a model of Alzheimer’s disease and frontotemporal dementia.
www.crick.ac.uk
June 25, 2025 at 3:12 PM
Researchers at the Crick and UCL have developed laboratory models of dementia, including Alzheimer's, to show that certain genetic messages are misplaced in diseased nerve cells.
The finding could offer a potential target for new treatments for neurodegeneration.
www.crick.ac.uk/news/2025-06...
The finding could offer a potential target for new treatments for neurodegeneration.
www.crick.ac.uk/news/2025-06...