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Ian Holmes

@ianholmes.org

4.7K followers 3.1K following 1.4K posts

Berkeley professor (Bioeng, Compbio). Visiting Scientist at Calico. JBrowse genome browser / Apollo annotation editor, ML for gene regulation / molecular evolution / synbio. Occasional music, games, jokes

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Ian Holmes @ianholmes.org · Jan 25

I feel moved to write about one of my technological heroes, possibly the most influential on my youth as an 8-bit hacker: a trans woman named Sophie Wilson. en.m.wikipedia.org/wiki/Sophie_...

Sophie Wilson - Wikipedia

en.m.wikipedia.org

Ian Holmes @ianholmes.org · 7h

Also yank out any subtext and proudly display it to everyone, like a Mortal Kombat spine rip. Well before they have the maturity or experience to even recognize the existence of subtext as a concept. This is quite important. They have to understand that showing off deeper insights is What Adults Do

Ian Holmes @ianholmes.org · 8h

It’s sort of your job to bore them away from video games with mundane behind-the-scene details: estimating the cost of every asset, commenting on likely tensions within the dev teams, deconstructing the design of their favorite levels etc

Ian Holmes @ianholmes.org · 8h

Left unchecked, the tendency of grad students to bribe their exam committees with ever-increasing amounts of sugar may produce such a bar as a byproduct of other research

Ian Holmes @ianholmes.org · 8h

“Statistically”, pronounced “(statistical lie)” bsky.app/profile/ianh...

Ian Holmes @ianholmes.org · 8h

Full-sized candy bars are actually the healthier option; by which I mean, you are statistically less likely to guzzle them down post-Halloween as if they were loose peanuts or raisins, as is known to be the case with surplus “fun-size” bars

John Scalzi @scalzi.com · 11h

Prepping for Halloween. We never get any kids at the house (because we live out of town at the end of a long driveway) but kids show up at the church for trick or treat, so we'll be ready. And indeed we are the Full-Sized Candy Bar People because we can be, and if you can, why wouldn't you.

Ian Holmes @ianholmes.org · 8h

This is based purely on my own individual anecdotal experience, and therefore the word “statistically” in the above should be properly regarded as an abbreviation for “statistical bullshit”

Ian Holmes @ianholmes.org · 8h

Full-sized candy bars are actually the healthier option; by which I mean, you are statistically less likely to guzzle them down post-Halloween as if they were loose peanuts or raisins, as is known to be the case with surplus “fun-size” bars

John Scalzi @scalzi.com · 11h

Prepping for Halloween. We never get any kids at the house (because we live out of town at the end of a long driveway) but kids show up at the church for trick or treat, so we'll be ready. And indeed we are the Full-Sized Candy Bar People because we can be, and if you can, why wouldn't you.

Boxes of candy bars, M&Ms, Skittles, and Starbursts

Ian Holmes @ianholmes.org · 13h

Any chance you can identify the cultivar from this photo? It looks on the lighter side of the range you posted

Me cutting up a Durian

Ian Holmes @ianholmes.org · 14h

Doc Brown: “1.21 givafucks?!?! This is going to require… a fucks capacitor.”

Ian Holmes @ianholmes.org · 1d

After all, there’s still a chance we might have to reverse some of these decisions, in the unfortunate event of a future Democratic administration.

Reposted by Ian Holmes

A.R. Moxon @juliusgoat.bsky.social · 3d

I've noticed the opposing team's fans only cheer when the opponents score on us. To win those fans over, I recommend we score on ourselves repeatedly; that will surely make them so happy they'll start supporting us. And I'm sure all our fans will keep cheering for us—who else is there to cheer for?

Reposted by Ian Holmes

sadvil 😎 @sadvil.bsky.social · 2d

A great weekend to share Jeff Bridges making a perfect joke

Ian Holmes @ianholmes.org · 2d

I don’t know what cultivar it is… I’d love to find out but it wasn’t labeled.

Any tips for how to get the best Durian experience?

Ian Holmes @ianholmes.org · 2d

Maybe it’s not fresh then, but it’s an actual fruit, as opposed to getting in ice cream or whatever other way I’ve tasted it. I am sure it would be better closer to source & earlier in the year. Still set me back a pretty penny and I am looking forward to trying it!

Ian Holmes @ianholmes.org · 2d

You left out the price tag; other than that, I think you nailed it. Like it nailed my shins

Ian Holmes @ianholmes.org · 2d

Bought a Durian because I’ve always wanted to try one fresh and man, this fruit is a practical joke on *multiple* levels

A durian fruit, big and spiky

Ian Holmes @ianholmes.org · 2d

I am stealing this, changing it to “Do you remember that song Kermit sings about his dominoes being cut in half”, and (hopefully) retiring on the profits. Thanks

Reposted by Ian Holmes

Alliance of Genome Resources @alliancegenome.bsky.social · 3d

The next Alliance webinar "A practical guide to Using the Alliance as a research resource" is Thurs. Oct 16, noon EDT Paul Sternberg will demonstrate how he uses the Alliance for comparative genomics in support of his research.

Register here to get the Zoom link by Weds Oct 15 tinyurl.com/4f9ycybt

Alliance Of Genome Resources Event Registration

Webinar recordings are posted at https://www.youtube.com/@AllianceOfGenomeResources A schedule of future events is on the Alliance Events Calendar https://www.alliancegenome.org/event-calendar

Ian Holmes @ianholmes.org · 4d

Pompous lectures on pronunciation… could you sound any primmer?

Reposted by Ian Holmes

Richard Waite @waiterich.bsky.social · 7d

Brassica oleracea / Brassica oleracea / Brassica oleracea

Three dudes dressed three very different ways - first in a more conservative suit and tie, second in a short sleeve shirt and hat, third in a pink vest and tie

Reposted by Ian Holmes

Federico Adolfi @fedeadolfi.bsky.social · 6d

**Me at a Halloween party**

Them, looking at my costume: what are you supposed to be?

Me: that’s a great question! Let’s think about it carefully step by step. You’re asking about my costu—

Them: no stop it

Ian Holmes @ianholmes.org · 6d

This is like when Apple started running BSD. Nice work.

Reposted by Ian Holmes

gavin jones @ecologyofgavin.bsky.social · 7d

Gaussian, beta, Poisson

Anil Kalhan @akalhan.bsky.social · 7d

University general counsel, university trustee, university president

Reposted by Ian Holmes

Edward T Eng @edwardteng.bsky.social · 9d

Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam.
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

Ian Holmes @ianholmes.org · 8d

SIMULATION - when a phone card is happy

Ian Holmes @ianholmes.org · 9d

Magic Alex would have made a better UI than this