Our findings reveal both shared and distinct Mtb responses of AM and MDM across species and highlight the need to use both animal models and human studies in tandem to dissect mechanisms of disease.

Big thank you to everyone who contributed to the project!

(5/5)

Lastly, examination of candidate genes revealed that low #MAF and #IL10 expression were two features that distinguished AM from MDM across species, suggesting regulation of cell proliferation and immunosuppression differs across macrophage subsets.

(4/5)

Second, we found that responses from murine AM isolated from #BCG vaccinated or coMtb-infected mice were more similar to responses of human AM than those from naive mice, suggesting that prior systemic exposure is critical for shaping the human airway immune response.

(3/5)

This team effort revealed several interesting findings...

First, we found that while all #macrophages generated strong #interferon responses to Mtb in vitro, AM from both species showed weaker inflammatory responses to Mtb than human MDM or murine BMDM, despite higher baseline levels.

(2/5)

Join our interdisciplinary research community!

#Immunosky #Reprosky #Devbio

Our department has a second TT search in #development and #reproduction.

careers.umass.edu/amherst/en-u...

Congratulations @bengern.bsky.social!