Lastly, examination of candidate genes revealed that low #MAF and #IL10 expression were two features that distinguished AM from MDM across species, suggesting regulation of cell proliferation and immunosuppression differs across macrophage subsets.

(4/5)

Second, we found that responses from murine AM isolated from #BCG vaccinated or coMtb-infected mice were more similar to responses of human AM than those from naive mice, suggesting that prior systemic exposure is critical for shaping the human airway immune response.

(3/5)

This team effort revealed several interesting findings...

First, we found that while all #macrophages generated strong #interferon responses to Mtb in vitro, AM from both species showed weaker inflammatory responses to Mtb than human MDM or murine BMDM, despite higher baseline levels.

(2/5)

Greenfield, MA #HandsOff #SocialJusticeSingout Standing room only!

It's #WorldTBDay. Let's remember that even before recent threats to #Tuberculosis funding, there was a funding gap for #TBdiagnosis, #TBtreatment, and #TBresearch.

We must increase (not decrease) global health investments to fight this epidemic.

Our lab is ready to #StandUpforScience in Amherst, MA! Where will you be at noon today?

In these dark times, conferences like #TBKeystone remind us how critical the scientific community is to our research. My lab is leaving the meeting committed to #Tuberculosis, #GlobalHealth, #immunology, and #InfectiousDisease. I'm grateful for all these fantastic and supportive scientists. #TBSky

Happy holidays from the Rothchild lab! ✨ I'm so lucky to be working with this group of talented, enthusiastic, and collaborative scientists!

A beautiful day to be in Woods Hole for #NEIC!

Can’t think of a more fitting way to spend #WorldTBDay than by heading to the #TBKeystone symposia!

#YesWeCanEndTB by ensuring we deliver the funding and actions for the development and availability of safe and effective new TB vaccines by 2028.

So proud of our lab for hosting a #UMassAmherst BTP Biotech Tales event: Host vs Bacteria in the Fight against #TB, especially our always-multitasking grad student Pamelia Lim, with additional help from the Siegrist lab. Thanks everyone for coming! Still working every day towards that host win!

A fun morning filled with microbiology at this year’s #PVMS2024 at #UMassAmherst Cheering on PhD student Pamelia Lim during her awesome talk! #ProudPI