Akis (Argyris) Papantonis
@akispapantonis.bsky.social
Biologist by training, basketball player at heart
Professor for Translational Epigenetics & Genome Architecture, University Medical Center Goettingen, Germany.
www.papantonislab.eu
Professor for Translational Epigenetics & Genome Architecture, University Medical Center Goettingen, Germany.
www.papantonislab.eu
Are you being pleasantly sarcastic????
November 20, 2025 at 1:46 PM
Are you being pleasantly sarcastic????
Thanks, Maria!
October 19, 2025 at 5:19 PM
Thanks, Maria!
Merci merci!
October 19, 2025 at 11:05 AM
Merci merci!
Thank you, Sandra — hope a German version appears soon!
October 19, 2025 at 8:38 AM
Thank you, Sandra — hope a German version appears soon!
The KO effects were far more pronounced than what the relative vU1 abundance (relative to canonical U1) would predict, and uncover an additional layer in stem cell identity regulation.
Please read here: www.biorxiv.org/cgi/content/...
Feedback more than welcome!
Please read here: www.biorxiv.org/cgi/content/...
Feedback more than welcome!
Variant U1 snRNAs contribute to cell cycle and differentiation control of human iPS cells
Maintenance of stem cell identity as well as differentiation of stem cells into the various lineages requires intricate regulation of gene expression. Despite intensive research, our understanding of ...
www.biorxiv.org
September 16, 2025 at 8:38 AM
The KO effects were far more pronounced than what the relative vU1 abundance (relative to canonical U1) would predict, and uncover an additional layer in stem cell identity regulation.
Please read here: www.biorxiv.org/cgi/content/...
Feedback more than welcome!
Please read here: www.biorxiv.org/cgi/content/...
Feedback more than welcome!
…so Kostas generated vU1-specific KOs using CRISPR-Cas9 in hiPSCs of the two most expressed variants, and Yajie analyzed their effects via total RNA-seq data, while @carmeloferrai.bsky.social provided undirected differentiation tests.
3/n
3/n
September 16, 2025 at 8:37 AM
…so Kostas generated vU1-specific KOs using CRISPR-Cas9 in hiPSCs of the two most expressed variants, and Yajie analyzed their effects via total RNA-seq data, while @carmeloferrai.bsky.social provided undirected differentiation tests.
3/n
3/n
We were motivated by my old @dunnschool.bsky.social neighbors, Shona Murphy and Dawn O’Reilly, who showed that these (falsely presumed) U1 pseudo genes may actually be functional in their 2013 Genome Res paper…
2/n
2/n
September 16, 2025 at 8:34 AM
We were motivated by my old @dunnschool.bsky.social neighbors, Shona Murphy and Dawn O’Reilly, who showed that these (falsely presumed) U1 pseudo genes may actually be functional in their 2013 Genome Res paper…
2/n
2/n