Akis (Argyris) Papantonis
@akispapantonis.bsky.social
Biologist by training, basketball player at heart
Professor for Translational Epigenetics & Genome Architecture, University Medical Center Goettingen, Germany.
www.papantonislab.eu
Professor for Translational Epigenetics & Genome Architecture, University Medical Center Goettingen, Germany.
www.papantonislab.eu
Last day of the @spp2202.bsky.social Closing Retreat in Goettingen ending in a high note with Stavros Lomvardas discussing the peculiar 3D attributes of the OR chromatin landscape!
November 12, 2025 at 10:23 AM
Last day of the @spp2202.bsky.social Closing Retreat in Goettingen ending in a high note with Stavros Lomvardas discussing the peculiar 3D attributes of the OR chromatin landscape!
@karsten-rippe.bsky.social rocking down memory lane and along single cell genomics data in Day 2 of the @spp2202.bsky.social Closing Retreat in Goettingen!
November 11, 2025 at 2:09 PM
@karsten-rippe.bsky.social rocking down memory lane and along single cell genomics data in Day 2 of the @spp2202.bsky.social Closing Retreat in Goettingen!
The Closing Scientific Retreat of @spp2202.bsky.social is under way in Goettingen with Gerd Blobel delivering the first Keynote lecture on LDB11-mediated looping of chromatin.
November 10, 2025 at 2:51 PM
The Closing Scientific Retreat of @spp2202.bsky.social is under way in Goettingen with Gerd Blobel delivering the first Keynote lecture on LDB11-mediated looping of chromatin.
Science-peripheral post (ignore unless you read in Greek or French): I was surprised and truly honored to receive the Aix-Marseille Metropolitain for the French translation of my novel ‘The last bear of the woods’ (Kichli 2023)—a great thanks to my translators M. Volkich and H. Zervas.
October 18, 2025 at 11:04 AM
Science-peripheral post (ignore unless you read in Greek or French): I was surprised and truly honored to receive the Aix-Marseille Metropolitain for the French translation of my novel ‘The last bear of the woods’ (Kichli 2023)—a great thanks to my translators M. Volkich and H. Zervas.
In our latest preprinted work, Yajie and Kostas combine computational analysis with precision KO of single variant U1 snRNA genes in human iPSCs to find pronounced deregulation of both gene expression and splicing that seem to affect the cell cycle and the differentiation potency of stem cells. 1/n
September 16, 2025 at 8:33 AM
In our latest preprinted work, Yajie and Kostas combine computational analysis with precision KO of single variant U1 snRNA genes in human iPSCs to find pronounced deregulation of both gene expression and splicing that seem to affect the cell cycle and the differentiation potency of stem cells. 1/n
...and in doing so, we also discuss how formations such as "factories" and "condensates" can mediate the communication of genes with their cognate cis-regulatory elements to tune their output in different scenarios.
5/n
5/n
June 19, 2025 at 4:52 PM
...and in doing so, we also discuss how formations such as "factories" and "condensates" can mediate the communication of genes with their cognate cis-regulatory elements to tune their output in different scenarios.
5/n
5/n
In our new review, we critically approach both the historical and current nomenclatures, as well as evidence from molecular and cell biology assays since the early '90s to highilght the (many) points where the two concepts align as well as those that still require further work to settle.
June 19, 2025 at 4:49 PM
In our new review, we critically approach both the historical and current nomenclatures, as well as evidence from molecular and cell biology assays since the early '90s to highilght the (many) points where the two concepts align as well as those that still require further work to settle.
The great pace of the "condensate" field has offered frameworks that can be used to explain earlier, but still very valid experimental observations. Thus, we set out to compare and contrast (and synthesize) the "transcription factory" model with what is known about "transcriptional condensates"
2/n
2/n
June 19, 2025 at 4:40 PM
The great pace of the "condensate" field has offered frameworks that can be used to explain earlier, but still very valid experimental observations. Thus, we set out to compare and contrast (and synthesize) the "transcription factory" model with what is known about "transcriptional condensates"
2/n
2/n
This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u
A short thread follows 1/n
A short thread follows 1/n
June 19, 2025 at 4:37 PM
This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u
A short thread follows 1/n
A short thread follows 1/n
Hear, hear!
Since last week, I have the honor of serving as a Scout for the Henriette Herz program of the Humboldt Foundation.
1/n
Since last week, I have the honor of serving as a Scout for the Henriette Herz program of the Humboldt Foundation.
1/n
June 17, 2025 at 7:28 PM
Hear, hear!
Since last week, I have the honor of serving as a Scout for the Henriette Herz program of the Humboldt Foundation.
1/n
Since last week, I have the honor of serving as a Scout for the Henriette Herz program of the Humboldt Foundation.
1/n
Mario Nicodemi kicking off SIBBM2025 with an elegant talk on phase transitions in 3D genome folding in front a wall-to-wall full house in Naples.
June 17, 2025 at 11:46 AM
Mario Nicodemi kicking off SIBBM2025 with an elegant talk on phase transitions in 3D genome folding in front a wall-to-wall full house in Naples.
Here’s the thing: the 2025 German Pathology Congress is kicking off in a huge room with a non-pathologist as first speaker.
Let’s see how Hi-C in cancer fairs today :-)
Let’s see how Hi-C in cancer fairs today :-)
June 12, 2025 at 6:48 AM
Here’s the thing: the 2025 German Pathology Congress is kicking off in a huge room with a non-pathologist as first speaker.
Let’s see how Hi-C in cancer fairs today :-)
Let’s see how Hi-C in cancer fairs today :-)
Always an emotional moment when one of your trainees graduates. Here, Dr. Adi Mackay (Danieli), 10th PhD from our lab, after an impeccable defense and a well-deserved "summa cum laude" distinction.
...paper will hopefully follow soon and it will become very clear why the distinction was awarded.
...paper will hopefully follow soon and it will become very clear why the distinction was awarded.
May 20, 2025 at 7:47 AM
Always an emotional moment when one of your trainees graduates. Here, Dr. Adi Mackay (Danieli), 10th PhD from our lab, after an impeccable defense and a well-deserved "summa cum laude" distinction.
...paper will hopefully follow soon and it will become very clear why the distinction was awarded.
...paper will hopefully follow soon and it will become very clear why the distinction was awarded.
Hear, hear!
The Universtiy Medical Center Goettingen is inviting applications to its new Medical Scientist Program
“Genomic responses to disease plasticity”
funded by the EKF Stiftung. The program will support early-career bioscientists with a PhD eager to do clinically-oriented research...
1/n
The Universtiy Medical Center Goettingen is inviting applications to its new Medical Scientist Program
“Genomic responses to disease plasticity”
funded by the EKF Stiftung. The program will support early-career bioscientists with a PhD eager to do clinically-oriented research...
1/n
January 27, 2025 at 7:51 AM
Hear, hear!
The Universtiy Medical Center Goettingen is inviting applications to its new Medical Scientist Program
“Genomic responses to disease plasticity”
funded by the EKF Stiftung. The program will support early-career bioscientists with a PhD eager to do clinically-oriented research...
1/n
The Universtiy Medical Center Goettingen is inviting applications to its new Medical Scientist Program
“Genomic responses to disease plasticity”
funded by the EKF Stiftung. The program will support early-career bioscientists with a PhD eager to do clinically-oriented research...
1/n
Our CRU5002 friends and collaborators in the Singh lab published (yet another) thorough paper dissecting how PDAC subtypes lose uniformity due to regional immune pressure, leading to the intratumoral subtype co-existence.
Happy to have contributed some genomics to this - read on: t.co/tqT4g9d39B
Happy to have contributed some genomics to this - read on: t.co/tqT4g9d39B
January 6, 2025 at 12:38 PM
Our CRU5002 friends and collaborators in the Singh lab published (yet another) thorough paper dissecting how PDAC subtypes lose uniformity due to regional immune pressure, leading to the intratumoral subtype co-existence.
Happy to have contributed some genomics to this - read on: t.co/tqT4g9d39B
Happy to have contributed some genomics to this - read on: t.co/tqT4g9d39B
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 11
#Books
#BookSky
#BookChallenge
Day 11
December 29, 2024 at 6:15 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 11
#Books
#BookSky
#BookChallenge
Day 11
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 8
#Books
#BookSky
#BookChallenge
Day 8
December 21, 2024 at 10:23 AM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 8
#Books
#BookSky
#BookChallenge
Day 8
Together with Andreas Beyer (CECAD), Adam Antebi (MPI-AGE) and Linda Partridge (UCL) we wrote Opinion article in TCB on accumulating data relating age-associated changes in transcriptional elongation with homeostatic deregulation.
Feedback welcome!
www.cell.com/trends/cell-...
Feedback welcome!
www.cell.com/trends/cell-...
December 20, 2024 at 2:42 PM
Together with Andreas Beyer (CECAD), Adam Antebi (MPI-AGE) and Linda Partridge (UCL) we wrote Opinion article in TCB on accumulating data relating age-associated changes in transcriptional elongation with homeostatic deregulation.
Feedback welcome!
www.cell.com/trends/cell-...
Feedback welcome!
www.cell.com/trends/cell-...
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 7
#Books
#BookSky
#BookChallenge
Day 7
December 20, 2024 at 9:13 AM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 7
#Books
#BookSky
#BookChallenge
Day 7
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 6
#Books
#BookSky
#BookChallenge
Day 6
December 16, 2024 at 2:51 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 6
#Books
#BookSky
#BookChallenge
Day 6
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 5
#Books
#BookSky
#BookChallenge
Day 5
December 15, 2024 at 8:36 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 5
#Books
#BookSky
#BookChallenge
Day 5
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 4
#Books
#BookSky
#BookChallenge
Day 4
December 14, 2024 at 6:03 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 4
#Books
#BookSky
#BookChallenge
Day 4
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 3
#Books
#BookSky
#BookChallenge
Day 3
December 13, 2024 at 11:04 AM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 3
#Books
#BookSky
#BookChallenge
Day 3
Plus Day 2 (as I am late in the game)
December 12, 2024 at 7:53 AM
Plus Day 2 (as I am late in the game)
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 1
#Books
#BookSky
#BookChallenge
Day 1
December 12, 2024 at 7:52 AM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 1
#Books
#BookSky
#BookChallenge
Day 1