Adrian Woolfson
@adrianwoolfson.bsky.social
Opinions @WSJ.com & @Science.org. Author Life Without Genes @harpercollins.bsky.social & On The Future of Species bloomsburybooksuk.bsky.social (12 Feb 2026) & @MITpress.bsky.social (17 Mar, 2026). www.adrianwoolfson.com. Founder Genyro.com
Brian Hie does it again! Evo can use surrounding genomic context to generate novel functional genes through an emergent approach called ‘semantic design’
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Semantic design of functional de novo genes from a genomic language model - Nature
By learning a semantics of gene function based on genomic context, the genomic language model Evo autocompletes DNA prompts to generate novel genes encoding protein and RNA molecules with defined acti...
www.nature.com
November 19, 2025 at 9:37 PM
Brian Hie does it again! Evo can use surrounding genomic context to generate novel functional genes through an emergent approach called ‘semantic design’
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microscopic programmable ‘flowers’ made from DNA. Autonomous behavior at microscale.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reversible metamorphosis of hierarchical DNA–inorganic crystals - Nature Nanotechnology
Actuators based on DNA–inorganic hybrid crystals reversibly change shape, which can be programmed by the length and composition of the DNA polymer, and induce cascaded reactions of compartmentalized e...
www.nature.com
November 18, 2025 at 2:42 AM
Microscopic programmable ‘flowers’ made from DNA. Autonomous behavior at microscale.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An artificial flower design toolkit
November 17, 2025 at 11:32 AM
An artificial flower design toolkit
My review of #Crick by @matthewcobb.bsky.social has been published online by @science.org. The book is lucid, beautifully crafted, and compelling. It will instantly become the definitive guide to this extraordinary individual’s life and work.
November 13, 2025 at 8:14 PM
My review of #Crick by @matthewcobb.bsky.social has been published online by @science.org. The book is lucid, beautifully crafted, and compelling. It will instantly become the definitive guide to this extraordinary individual’s life and work.
I am greatly enjoying #TheTreeofLife by @maxjtelford.bsky.social published by @wwnorton.com, which I am reviewing for @wsj.com
November 10, 2025 at 2:02 PM
I am greatly enjoying #TheTreeofLife by @maxjtelford.bsky.social published by @wwnorton.com, which I am reviewing for @wsj.com
I tremendously enjoyed Matthew Cobb’s definitive new biography of Crick. It was hard to put down and provides many new perspectives. My review of it will appear in Science later this week.
November 10, 2025 at 1:45 PM
I tremendously enjoyed Matthew Cobb’s definitive new biography of Crick. It was hard to put down and provides many new perspectives. My review of it will appear in Science later this week.
Reposted by Adrian Woolfson
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
bit.ly/3VMcyNZ
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
bit.ly
October 4, 2025 at 2:40 PM
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
bit.ly/3VMcyNZ
Reposted by Adrian Woolfson
Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).
Biophysicists are realizing that there is an undervalued element at play in early development: Aside from genes, mechanical forces also steer the growth of embryos. @annademming.bsky.social reports: www.quantamagazine.org/genes-have-h...
Genes Have Harnessed Physics to Help Grow Living Things | Quanta Magazine
The same pulling force that causes “tears” in a glass of wine also shapes embryos. It’s another example of how genes exploit mechanical forces for growth and development.
www.quantamagazine.org
October 11, 2025 at 7:04 AM
Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).
Fusing transcription factors (TFs) to intrinsically disordered regions (IDRs), to drive the formation of transcriptional condensates that concentrate TFs at their target promoters.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Phase separation to buffer growth-mediated dilution in synthetic circuits
Fluctuations in host cell growth pose a critical challenge for maintaining reliable function in synthetic gene circuits. Growth-mediated dilution caus…
www.sciencedirect.com
November 8, 2025 at 11:55 AM
Fusing transcription factors (TFs) to intrinsically disordered regions (IDRs), to drive the formation of transcriptional condensates that concentrate TFs at their target promoters.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...