Gordon H. Guyatt
@guyattgh.bsky.social
Promoting use of the best evidence and patient values and preferences to inform optimal clinical and health policy decisions.
Gordon Henry Guyatt is a Canadian physician who is a professor at McMaster University in Hamilton, Ontario. He is known for his leadership in evidence-based medicine, a term that first appeared in a single-author paper he published in 1991. Subsequently, a 1992 JAMA article led by Guyatt proved instrumental in bringing the concept of evidence-based medicine to the world's attention. Guyatt's concerns with the role of the medical system, social justice, and medical reform remain central issues that he promoted in tandem with his medical work. He was named to the Canadian Medical Hall of Fame in 2015. .. more
Economics
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Mathematics
24%
A Systematic Survey of the Optimal Strategy for Dealing With Missing Binary Outcomes in Simulation Studies of Randomized Controlled Trials - PubMed
Simulation studies address methods to deal with MBOD in RCTs, provided evidence that the MI approach is superior with respect to bias and coverage compared with CCA. Non-model-based single imputation generally performed poorly.
pubmed.ncbi.nlm.nih.gov
Recent simulation studies: how should #RCTs with binary outcomes address #MissingData? Multiple imputation best, single imputation, complete case less well. Data missing not at random, typical situation, nothing works well. Missing data risks #bias, too bad.
pubmed.ncbi.nlm.nih.gov/40856174/
pubmed.ncbi.nlm.nih.gov/40856174/
A clinician's guide for conducting randomized trials in individual patients - PubMed
In determining optimal treatment for a patient conventional trials of therapy are susceptible to bias. Large-scale randomized trials can provide only a partial guide and have not been or cannot be carried out for most clinical disorders. However, randomized controlled trials (RCTs) in individual pat …
pubmed.ncbi.nlm.nih.gov
#RandomizedTrials in individual patients – #Nof1 #RCTs – provide the highest certainty evidence of treatment impact in an individual. The epitome of best clinical practice. This article gives a step by step for setting up and running an N of 1 trial.
pubmed.ncbi.nlm.nih.gov/3409138/
pubmed.ncbi.nlm.nih.gov/3409138/
https://www.clarityresearch.ca/frequently-asked-questions
t.co
Core #GRADE, 7 articles in #BMJ this spring, one-stop-shopping for those who want to get GRADE right with the essentials. Now also frequently asked question – latest post considers a priori hypotheses to explain #heterogeneity. All questions welcome, send to [email protected]
t.co/hh6owWxn5O
t.co/hh6owWxn5O
Meta-analysis of antibiotics versus appendicectomy for non-perforated acute appendicitis - PubMed
The choice of medical versus surgical management in patients with clearly uncomplicated appendicitis is value- and preference-dependent, suggesting a change in practice towards shared decision-making is necessary.
pubmed.ncbi.nlm.nih.gov
This #SystematicReview and #MetaAnalysis shook up the surgical world when results suggested that #antibiotics rather than #surgery may, for many patients, be the best management for their #appendicitis.
pubmed.ncbi.nlm.nih.gov/26990957/
pubmed.ncbi.nlm.nih.gov/26990957/
The GRADE approach and Bradford Hill's criteria for causation - PubMed
This article describes how the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to grading the quality of evidence and strength of recommendations considers the Bradford Hill criteria for causation and how GRADE may relate to questions in public health. A primary co …
pubmed.ncbi.nlm.nih.gov
#BradfordHill’s iconic criteria for addressing #causation still resonates with many. How do those criteria relate to #GRADE’s certainty of evidence for causation? This paper explains.
pubmed.ncbi.nlm.nih.gov/20947872/
pubmed.ncbi.nlm.nih.gov/20947872/
Just back from a trip to #Chengdu, the birthplace of #EBM, where applying EBM to #TraditionalChineseMedicine and thus advance #TCM on the global stage is all the rage. With my first Chinese Phd student Xin Sun, now number 1 in EBM in China, and his colleagues.
#evidence #ebm #medicine | Gordon Guyatt
In this one minute video I explain how a person who takes an #Evidence based approach to life responds when asked a question for which they don’t know the evidence.
#EBM #medicine
www.linkedin.com
In this one minute video I explain how a person who takes an #Evidence based approach to life responds when asked a question for which they don’t know the evidence.
@leticiakawano.bsky.social
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@leticiakawano.bsky.social
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GRADE guidelines: 10. Considering resource use and rating the quality of economic evidence - PubMed
With our framework, decision makers will have access to concise summaries of recommendations, including ratings of the quality of economic evidence, and better understand the implications for clinical decision making.
pubmed.ncbi.nlm.nih.gov
Addressing costs in #SystematicReviews is challenging and applying #GRADE to rate certainty of evidence particularly so. This paper shows you how.
pubmed.ncbi.nlm.nih.gov/22863410/
pubmed.ncbi.nlm.nih.gov/22863410/
Biking with my friend and former mentee Mohit Bhandari, now leading clinical trialist in orthopedic trauma, leader in intimate partner violence research and Chair of Surgery at #McMaster.
Users' guides to the medical literature. XII. How to use articles about health-related quality of life. Evidence-Based Medicine Working Group - PubMed
Users' guides to the medical literature. XII. How to use articles about health-related quality of life. Evidence-Based Medicine Working Group
pubmed.ncbi.nlm.nih.gov
This #JAMA Users’ guide to the medical literature explains how to use an article that addresses how to understand and interpret articles about patients’ #QualityofLife usually measured using #PatientReportedOutcomes (PRO).
pubmed.ncbi.nlm.nih.gov/9103349/
pubmed.ncbi.nlm.nih.gov/9103349/
Remembering Drummond Rennie—Champion of Integrity in Science and Scientific Publication
Drummond Rennie, physician, scientist, editor, climber, tireless promoter of integrity and transparency in science, and mentor to many, died on September 12, 2025, at the age of 89.
jamanetwork.com
#JAMA editor Drummond Rennie who died recently acted as the champion of the JAMA Users’ Guides to the Medical Literature. Without his advocacy the series would never have happened and the #EBM movement might never have got off the ground.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Red Blood Cell Transfusion: 2023 AABB International Guidelines - PubMed
It is good practice to consider overall clinical context and alternative therapies to transfusion when making transfusion decisions about an individual patient.
pubmed.ncbi.nlm.nih.gov
When to give #RBCtransfusion for hospitalized patients with #anemia: Definitive updated trustworthy #guidelines, #JAMA publication.
pubmed.ncbi.nlm.nih.gov/37824153/
pubmed.ncbi.nlm.nih.gov/37824153/
#grade | Gordon Guyatt
In this one minute tutorial, I explain the meaning and significance of a weak or conditional #GRADE recommendation.
Leticia Kawano-Dourado, MD, PhD
www.linkedin.com
In this one minute tutorial, I explain the meaning and significance of a weak or conditional #GRADE recommendation.
www.linkedin.com/feed/update/...
www.linkedin.com/feed/update/...
A clinician's guide for conducting randomized trials in individual patients
In determining optimal treatment for a patient conventional trials of therapy are susceptible to bias. Large-scale randomized trials can provide only a partial guide and have not been or cannot be car...
www.cmaj.ca
Anyone interested in determining the effect of a drug in a single patient by conducting a #RandomizedTrial in a that patient – an N of 1 trial – will find this step-by-step guide enormously useful.
www.cmaj.ca/content/139/...
www.cmaj.ca/content/139/...
GRADE guidelines: 21 part 1. Study design, risk of bias, and indirectness in rating the certainty across a body of evidence for test accuracy - PubMed
Rating the certainty of a body of evidence using GRADE in Cochrane and other reviews and World Health Organization and other guidelines dealing with in TA studies helped refining our approach. The resulting guidance will help applying GRADE successfully for questions and recommendations focusing on …
pubmed.ncbi.nlm.nih.gov
If you are using #GRADE to rate #CertaintyofEvidence for diagnostic tests this article that deals with study design, #RiskofBias, and #indirectness provides crucial guidance.
pubmed.ncbi.nlm.nih.gov/32060007/
pubmed.ncbi.nlm.nih.gov/32060007/