Yuki Kotani, MD
@yukikotani.bsky.social
Deputy Director of the Department of Intensive Care Medicine, Kameda Medical Center, Japan.
Pinned
🧠 Sedation in the ICU: are volatile anesthetics better than IV anesthetics?
Our meta-analysis of 21 RCTs (n=2,367): volatile sedation ↑ mortality (RR 1.17 [1.02–1.35]) vs. IV Sedation
⚠️ Routine use is not supported. Consider only in selected patients.
🔗 ccforum.biomedcentral.com/articles/10....
Our meta-analysis of 21 RCTs (n=2,367): volatile sedation ↑ mortality (RR 1.17 [1.02–1.35]) vs. IV Sedation
⚠️ Routine use is not supported. Consider only in selected patients.
🔗 ccforum.biomedcentral.com/articles/10....
Reposted by Yuki Kotani, MD
Once again, the emperor of inductive physiological reasoning is revealed to have no clothes...
In >1,100 high-risk surgical patients, individualized periop BP targets based on pre-op nocturnal MAP were not associated with ↓ kidney or cardiac injury vs routine MAP ≥65 mm Hg
CCR Journal Watch – tracking the critical care literature daily
criticalcarereviews.com/latest-evide...
CCR Journal Watch – tracking the critical care literature daily
criticalcarereviews.com/latest-evide...
October 13, 2025 at 7:20 AM
Once again, the emperor of inductive physiological reasoning is revealed to have no clothes...
Reposted by Yuki Kotani, MD
💧Early diuretics after cardiac surgery?
No gain, potential pain
In this post-hoc analysis of the #BROTHERstudy early IV diuresis didn’t prevent #AKI and prolonged hospitalization
🔗 www.signavitae.com/articles/10.22514/sv.2023.112
#Anesthesia #CardiacSurgery #ICU #MedEd
@yukikotani.bsky.social
No gain, potential pain
In this post-hoc analysis of the #BROTHERstudy early IV diuresis didn’t prevent #AKI and prolonged hospitalization
🔗 www.signavitae.com/articles/10.22514/sv.2023.112
#Anesthesia #CardiacSurgery #ICU #MedEd
@yukikotani.bsky.social
July 7, 2025 at 12:15 PM
💧Early diuretics after cardiac surgery?
No gain, potential pain
In this post-hoc analysis of the #BROTHERstudy early IV diuresis didn’t prevent #AKI and prolonged hospitalization
🔗 www.signavitae.com/articles/10.22514/sv.2023.112
#Anesthesia #CardiacSurgery #ICU #MedEd
@yukikotani.bsky.social
No gain, potential pain
In this post-hoc analysis of the #BROTHERstudy early IV diuresis didn’t prevent #AKI and prolonged hospitalization
🔗 www.signavitae.com/articles/10.22514/sv.2023.112
#Anesthesia #CardiacSurgery #ICU #MedEd
@yukikotani.bsky.social
🧠 Sedation in the ICU: are volatile anesthetics better than IV anesthetics?
Our meta-analysis of 21 RCTs (n=2,367): volatile sedation ↑ mortality (RR 1.17 [1.02–1.35]) vs. IV Sedation
⚠️ Routine use is not supported. Consider only in selected patients.
🔗 ccforum.biomedcentral.com/articles/10....
Our meta-analysis of 21 RCTs (n=2,367): volatile sedation ↑ mortality (RR 1.17 [1.02–1.35]) vs. IV Sedation
⚠️ Routine use is not supported. Consider only in selected patients.
🔗 ccforum.biomedcentral.com/articles/10....
June 6, 2025 at 5:16 AM
🧠 Sedation in the ICU: are volatile anesthetics better than IV anesthetics?
Our meta-analysis of 21 RCTs (n=2,367): volatile sedation ↑ mortality (RR 1.17 [1.02–1.35]) vs. IV Sedation
⚠️ Routine use is not supported. Consider only in selected patients.
🔗 ccforum.biomedcentral.com/articles/10....
Our meta-analysis of 21 RCTs (n=2,367): volatile sedation ↑ mortality (RR 1.17 [1.02–1.35]) vs. IV Sedation
⚠️ Routine use is not supported. Consider only in selected patients.
🔗 ccforum.biomedcentral.com/articles/10....
🩸 Our new meta-analysis on arterial line blood cultures
Contamination rate with arterial catheter–drawn cultures was comparable to venipuncture & lower vs venous catheter–drawn cultures
📌 In critically ill adults, arterial line sampling may be a reasonable alternative.
doi.org/10.1093/cid/...
Contamination rate with arterial catheter–drawn cultures was comparable to venipuncture & lower vs venous catheter–drawn cultures
📌 In critically ill adults, arterial line sampling may be a reasonable alternative.
doi.org/10.1093/cid/...
Contamination of blood cultures drawn from arterial catheters versus venipuncture or venous catheters in critically ill patients: a systematic review and meta-analysis
AbstractBackground. Arterial catheter-drawn blood culture sampling may reduce patient discomfort and healthcare providers’ workload. Guidelines discourage
doi.org
May 27, 2025 at 8:09 AM
🩸 Our new meta-analysis on arterial line blood cultures
Contamination rate with arterial catheter–drawn cultures was comparable to venipuncture & lower vs venous catheter–drawn cultures
📌 In critically ill adults, arterial line sampling may be a reasonable alternative.
doi.org/10.1093/cid/...
Contamination rate with arterial catheter–drawn cultures was comparable to venipuncture & lower vs venous catheter–drawn cultures
📌 In critically ill adults, arterial line sampling may be a reasonable alternative.
doi.org/10.1093/cid/...
🩺 Clinical implications:
1️⃣ Routine switch from propofol-based sedation is not supported
2️⃣ In patients requiring deep sedation, Dex/Clon may be suboptimal due to agitation
3️⃣ Monitor for bradycardia when using Dex or Clon
📄 Full article:
jamanetwork.com/journals/jam...
1️⃣ Routine switch from propofol-based sedation is not supported
2️⃣ In patients requiring deep sedation, Dex/Clon may be suboptimal due to agitation
3️⃣ Monitor for bradycardia when using Dex or Clon
📄 Full article:
jamanetwork.com/journals/jam...
Dexmedetomidine- or Clonidine-Based Sedation vs Propofol in Critically Ill Patients
This randomized clinical trial compares the effects of dexmedetomidine- or clonidine-based sedation vs propofol-based sedation (usual care) on the duration of mechanical ventilation in critically ill ...
jamanetwork.com
May 20, 2025 at 1:49 AM
🩺 Clinical implications:
1️⃣ Routine switch from propofol-based sedation is not supported
2️⃣ In patients requiring deep sedation, Dex/Clon may be suboptimal due to agitation
3️⃣ Monitor for bradycardia when using Dex or Clon
📄 Full article:
jamanetwork.com/journals/jam...
1️⃣ Routine switch from propofol-based sedation is not supported
2️⃣ In patients requiring deep sedation, Dex/Clon may be suboptimal due to agitation
3️⃣ Monitor for bradycardia when using Dex or Clon
📄 Full article:
jamanetwork.com/journals/jam...
💡 Interpretation:
Dex and Clon were expected to facilitate extubation due to lighter sedation
However, in ~25–30% of cases, deep sedation was unavoidable
High propofol co-use diluted between-group differences
No reduction in delirium with dex, contrary to prior hopes
Dex and Clon were expected to facilitate extubation due to lighter sedation
However, in ~25–30% of cases, deep sedation was unavoidable
High propofol co-use diluted between-group differences
No reduction in delirium with dex, contrary to prior hopes
May 20, 2025 at 1:49 AM
💡 Interpretation:
Dex and Clon were expected to facilitate extubation due to lighter sedation
However, in ~25–30% of cases, deep sedation was unavoidable
High propofol co-use diluted between-group differences
No reduction in delirium with dex, contrary to prior hopes
Dex and Clon were expected to facilitate extubation due to lighter sedation
However, in ~25–30% of cases, deep sedation was unavoidable
High propofol co-use diluted between-group differences
No reduction in delirium with dex, contrary to prior hopes
⚠️ Safety concerns:
Bradycardia (HR < 50): Increased with both Dex and Clon
Agitation (RASS +3–4): Also increased in both groups
Delirium (via CAM-ICU): No difference
Bradycardia (HR < 50): Increased with both Dex and Clon
Agitation (RASS +3–4): Also increased in both groups
Delirium (via CAM-ICU): No difference
May 20, 2025 at 1:49 AM
⚠️ Safety concerns:
Bradycardia (HR < 50): Increased with both Dex and Clon
Agitation (RASS +3–4): Also increased in both groups
Delirium (via CAM-ICU): No difference
Bradycardia (HR < 50): Increased with both Dex and Clon
Agitation (RASS +3–4): Also increased in both groups
Delirium (via CAM-ICU): No difference
💉 Real-world sedation use:
Target RASS: –2 to +1
20–30% required deep sedation per clinician judgment
Even in Dex/Clon groups, propofol was used during ~75–77% of sedation days
🎯 Primary outcome: No difference in time to extubation success across groups
Target RASS: –2 to +1
20–30% required deep sedation per clinician judgment
Even in Dex/Clon groups, propofol was used during ~75–77% of sedation days
🎯 Primary outcome: No difference in time to extubation success across groups
May 20, 2025 at 1:49 AM
💉 Real-world sedation use:
Target RASS: –2 to +1
20–30% required deep sedation per clinician judgment
Even in Dex/Clon groups, propofol was used during ~75–77% of sedation days
🎯 Primary outcome: No difference in time to extubation success across groups
Target RASS: –2 to +1
20–30% required deep sedation per clinician judgment
Even in Dex/Clon groups, propofol was used during ~75–77% of sedation days
🎯 Primary outcome: No difference in time to extubation success across groups
🏥 Overview:
41 ICUs, 1,404 patients
🧩 PICO (3-arm):
P: Adults expected to require ≥48h of MV
I: Sedation primarily with ① dexmedetomidine or ② clonidine
C: Sedation primarily with propofol
O: Time from randomization to 48h of sustained spontaneous breathing (i.e., extubation success)
41 ICUs, 1,404 patients
🧩 PICO (3-arm):
P: Adults expected to require ≥48h of MV
I: Sedation primarily with ① dexmedetomidine or ② clonidine
C: Sedation primarily with propofol
O: Time from randomization to 48h of sustained spontaneous breathing (i.e., extubation success)
May 20, 2025 at 1:49 AM
🏥 Overview:
41 ICUs, 1,404 patients
🧩 PICO (3-arm):
P: Adults expected to require ≥48h of MV
I: Sedation primarily with ① dexmedetomidine or ② clonidine
C: Sedation primarily with propofol
O: Time from randomization to 48h of sustained spontaneous breathing (i.e., extubation success)
41 ICUs, 1,404 patients
🧩 PICO (3-arm):
P: Adults expected to require ≥48h of MV
I: Sedation primarily with ① dexmedetomidine or ② clonidine
C: Sedation primarily with propofol
O: Time from randomization to 48h of sustained spontaneous breathing (i.e., extubation success)
🆕 New RCT in JAMA: Sedation in mechanically ventilated ICU patients—Dexmedetomidine vs Clonidine vs Propofol
📕 Main takeaway: In critically ill patients, neither dexmedetomidine nor clonidine shortened time to successful extubation compared to propofol.
📕 Main takeaway: In critically ill patients, neither dexmedetomidine nor clonidine shortened time to successful extubation compared to propofol.
May 20, 2025 at 1:49 AM
🆕 New RCT in JAMA: Sedation in mechanically ventilated ICU patients—Dexmedetomidine vs Clonidine vs Propofol
📕 Main takeaway: In critically ill patients, neither dexmedetomidine nor clonidine shortened time to successful extubation compared to propofol.
📕 Main takeaway: In critically ill patients, neither dexmedetomidine nor clonidine shortened time to successful extubation compared to propofol.
Reposted by Yuki Kotani, MD
🎓 Applications are OPEN for the 1️⃣ #ESICMNEXT 𝗚𝗲𝗻𝗜𝗨𝗦 𝗙𝗲𝗹𝗹𝗼𝘄𝘀𝗵𝗶𝗽𝘀 — a 5-day hands-on training in General Intensive Care Ultrasound!
🌍 30 young intensivists will train at 7 top centres across Europe 🗓️ 𝗢𝗰𝘁 𝟭𝟯–𝟭𝟳, 𝟮𝟬𝟮𝟱
🗓️ Apply by 𝗠𝗮𝘆 𝟮𝟬 👉 www.esicm.org/newfellowshi...
#IntensiveCare #GenIUSFellowship
🌍 30 young intensivists will train at 7 top centres across Europe 🗓️ 𝗢𝗰𝘁 𝟭𝟯–𝟭𝟳, 𝟮𝟬𝟮𝟱
🗓️ Apply by 𝗠𝗮𝘆 𝟮𝟬 👉 www.esicm.org/newfellowshi...
#IntensiveCare #GenIUSFellowship
NEXT Fellowship in General Intensive Care Ultrasound (GenIUS) - ESICM
www.esicm.org
April 30, 2025 at 11:00 AM
🎓 Applications are OPEN for the 1️⃣ #ESICMNEXT 𝗚𝗲𝗻𝗜𝗨𝗦 𝗙𝗲𝗹𝗹𝗼𝘄𝘀𝗵𝗶𝗽𝘀 — a 5-day hands-on training in General Intensive Care Ultrasound!
🌍 30 young intensivists will train at 7 top centres across Europe 🗓️ 𝗢𝗰𝘁 𝟭𝟯–𝟭𝟳, 𝟮𝟬𝟮𝟱
🗓️ Apply by 𝗠𝗮𝘆 𝟮𝟬 👉 www.esicm.org/newfellowshi...
#IntensiveCare #GenIUSFellowship
🌍 30 young intensivists will train at 7 top centres across Europe 🗓️ 𝗢𝗰𝘁 𝟭𝟯–𝟭𝟳, 𝟮𝟬𝟮𝟱
🗓️ Apply by 𝗠𝗮𝘆 𝟮𝟬 👉 www.esicm.org/newfellowshi...
#IntensiveCare #GenIUSFellowship
Reposted by Yuki Kotani, MD
📢 Your 𝗹𝗮𝘁𝗲𝘀𝘁 𝗶𝘀𝘀𝘂𝗲 of the @intenscaremed.bsky.social with the latest articles is here! 📖 𝗙𝗼𝗹𝗹𝗼𝘄 𝘂𝘀 & stay updated with the latest research, delivered straight to you.
📍 Read all the latest articles here 👉 www.esicm.org/icm-latest-i...
#ICM #ESICM #Research #MedicalJournals #IntensiveCare
📍 Read all the latest articles here 👉 www.esicm.org/icm-latest-i...
#ICM #ESICM #Research #MedicalJournals #IntensiveCare
May 2, 2025 at 12:00 PM
📢 Your 𝗹𝗮𝘁𝗲𝘀𝘁 𝗶𝘀𝘀𝘂𝗲 of the @intenscaremed.bsky.social with the latest articles is here! 📖 𝗙𝗼𝗹𝗹𝗼𝘄 𝘂𝘀 & stay updated with the latest research, delivered straight to you.
📍 Read all the latest articles here 👉 www.esicm.org/icm-latest-i...
#ICM #ESICM #Research #MedicalJournals #IntensiveCare
📍 Read all the latest articles here 👉 www.esicm.org/icm-latest-i...
#ICM #ESICM #Research #MedicalJournals #IntensiveCare
Guidelines for CPB in adult cardiac surgery
The CPB can only be performed through collaboration between cardiac surgeons, anesthesiologists, and perfusionists.
This European guideline covers hot topics, such as intravenous amino acid therapy for AKI prevention.
www.bjanaesthesia.org/article/S000...
The CPB can only be performed through collaboration between cardiac surgeons, anesthesiologists, and perfusionists.
This European guideline covers hot topics, such as intravenous amino acid therapy for AKI prevention.
www.bjanaesthesia.org/article/S000...
2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery
Clinical practice guidelines consolidate and evaluate all pertinent evidence on a
specific topic available at the time of their formulation. The goal is to assist physicians
in determining the most ef...
www.bjanaesthesia.org
February 16, 2025 at 4:41 AM
Guidelines for CPB in adult cardiac surgery
The CPB can only be performed through collaboration between cardiac surgeons, anesthesiologists, and perfusionists.
This European guideline covers hot topics, such as intravenous amino acid therapy for AKI prevention.
www.bjanaesthesia.org/article/S000...
The CPB can only be performed through collaboration between cardiac surgeons, anesthesiologists, and perfusionists.
This European guideline covers hot topics, such as intravenous amino acid therapy for AKI prevention.
www.bjanaesthesia.org/article/S000...
Both frequentist and Bayesian approaches are important to interpret the findings of critical care research.
ccforum.biomedcentral.com/articles/10....
ccforum.biomedcentral.com/articles/10....
Death by p-value: the overreliance on p-values in critical care research - Critical Care
The p-value has changed from a versatile tool for scientific reasoning to a strict judge of medical information, with the usual 0.05 cutoff frequently deciding a study’s significance and subsequent cl...
ccforum.biomedcentral.com
February 12, 2025 at 9:52 AM
Both frequentist and Bayesian approaches are important to interpret the findings of critical care research.
ccforum.biomedcentral.com/articles/10....
ccforum.biomedcentral.com/articles/10....
This secondary analysis of an RCT examined whether the risk of death changes between balanced crystalloids and saline depending on the Cl concentration.
The higher the Cl concentration, the more the point estimates of mortality risk favor balanced crystalloids.
link.springer.com/article/10.1...
The higher the Cl concentration, the more the point estimates of mortality risk favor balanced crystalloids.
link.springer.com/article/10.1...
Serum chloride concentration and outcomes in adults receiving intravenous fluid therapy with a balanced crystalloid solution or 0.9% sodium chloride - Intensive Care Medicine
Purpose To determine whether there is an interaction between baseline serum chloride concentration and pH and treatment effects in Intensive Care Unit (ICU) patients receiving intravenous fluid therap...
link.springer.com
February 12, 2025 at 9:50 AM
This secondary analysis of an RCT examined whether the risk of death changes between balanced crystalloids and saline depending on the Cl concentration.
The higher the Cl concentration, the more the point estimates of mortality risk favor balanced crystalloids.
link.springer.com/article/10.1...
The higher the Cl concentration, the more the point estimates of mortality risk favor balanced crystalloids.
link.springer.com/article/10.1...
Pathological physiology, clinical significance, and differential diagnosis of euglycemic DKA by SGLT2 inhibitors
idp.springer.com/authorize?re...
idp.springer.com/authorize?re...
Understanding the disease: euglycemic ketoacidosis with SGLT2 inhibitors - Intensive Care Medicine
Intensive Care Medicine -
idp.springer.com
February 4, 2025 at 10:24 AM
Pathological physiology, clinical significance, and differential diagnosis of euglycemic DKA by SGLT2 inhibitors
idp.springer.com/authorize?re...
idp.springer.com/authorize?re...
Recently, it has been mostly accepted that ketamine does not increase intracranial pressure. Rather, thanks to its hemodynamic tolerance, ketamine can avoid hypotension and maintain cerebral perfusion pressure when used as an induction agent for intubation.
www.bjanaesthesia.org/article/S000...
www.bjanaesthesia.org/article/S000...
The diverse effects of ketamine, jack-of-all-trades: a narrative review
Ketamine, an N-methyl-D-aspartic acid receptor antagonist that was first discovered
in 1962, has become established in anaesthesia providing dose-dependent anaesthetic,
sedative, and analgesic effects...
www.bjanaesthesia.org
January 31, 2025 at 12:58 PM
Recently, it has been mostly accepted that ketamine does not increase intracranial pressure. Rather, thanks to its hemodynamic tolerance, ketamine can avoid hypotension and maintain cerebral perfusion pressure when used as an induction agent for intubation.
www.bjanaesthesia.org/article/S000...
www.bjanaesthesia.org/article/S000...
Heterogeneity in the therapeutic effects of oxygen therapy in critically ill patients
Different baseline conditions, acute diseases, and concurrent interventions likely modify the optimal goals for oxygen therapy. Two large RCTs may guide future practice.
ccforum.biomedcentral.com/articles/10....
Different baseline conditions, acute diseases, and concurrent interventions likely modify the optimal goals for oxygen therapy. Two large RCTs may guide future practice.
ccforum.biomedcentral.com/articles/10....
January 29, 2025 at 11:29 PM
Heterogeneity in the therapeutic effects of oxygen therapy in critically ill patients
Different baseline conditions, acute diseases, and concurrent interventions likely modify the optimal goals for oxygen therapy. Two large RCTs may guide future practice.
ccforum.biomedcentral.com/articles/10....
Different baseline conditions, acute diseases, and concurrent interventions likely modify the optimal goals for oxygen therapy. Two large RCTs may guide future practice.
ccforum.biomedcentral.com/articles/10....
Thanks a lot for our paper!
journals.lww.com/ccmjournal/f...
journals.lww.com/ccmjournal/f...
Induction Agents for Tracheal Intubation in Critically Ill... : Critical Care Medicine
tracheal intubation in critically ill patients.
STUDY SELECTION:
We included randomized controlled trials and observational studies that reported patient outcomes.
DATA EXTRACTION:
Data from inc...
journals.lww.com
January 27, 2025 at 11:51 AM
Thanks a lot for our paper!
journals.lww.com/ccmjournal/f...
journals.lww.com/ccmjournal/f...
Reposted by Yuki Kotani, MD
Induction Agents for Tracheal Intubation in Critically Ill Patients
CCR Journal Watch
criticalcarereviews.com/latest-evide...
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at criticalcarereviews.com/newsletters/...
CCR Journal Watch
criticalcarereviews.com/latest-evide...
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at criticalcarereviews.com/newsletters/...
January 27, 2025 at 11:45 AM
Induction Agents for Tracheal Intubation in Critically Ill Patients
CCR Journal Watch
criticalcarereviews.com/latest-evide...
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at criticalcarereviews.com/newsletters/...
CCR Journal Watch
criticalcarereviews.com/latest-evide...
Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at criticalcarereviews.com/newsletters/...
What happens to hemodynamics in ARDS patients after VV ECMO initiation?
Improvements occurred in 61% at 2 h & 83% at 24 h.
The main causes seem to be improved respiratory parameters & acid-base balance and a reduction in ventilator support.
www.jcvaonline.com/article/S105...
Improvements occurred in 61% at 2 h & 83% at 24 h.
The main causes seem to be improved respiratory parameters & acid-base balance and a reduction in ventilator support.
www.jcvaonline.com/article/S105...
Hemodynamic improvement in ARDS patients after VV ECMO implantation
Severe acute respiratory distress syndrome (ARDS) is often complicated by hemodynamic
instability requiring pharmacological support. Venovenous extracorporeal membrane
oxygenation (VV ECMO) is a well-...
www.jcvaonline.com
January 25, 2025 at 12:54 PM
What happens to hemodynamics in ARDS patients after VV ECMO initiation?
Improvements occurred in 61% at 2 h & 83% at 24 h.
The main causes seem to be improved respiratory parameters & acid-base balance and a reduction in ventilator support.
www.jcvaonline.com/article/S105...
Improvements occurred in 61% at 2 h & 83% at 24 h.
The main causes seem to be improved respiratory parameters & acid-base balance and a reduction in ventilator support.
www.jcvaonline.com/article/S105...
Review article on AKI: Lancet
This is a must-read paper that covers not only the epidemiology, pathophysiology, and management of AKI, but also crosstalk with other organs during the acute phase and long-term adverse effects on other organs.
www.thelancet.com/journals/lan...
This is a must-read paper that covers not only the epidemiology, pathophysiology, and management of AKI, but also crosstalk with other organs during the acute phase and long-term adverse effects on other organs.
www.thelancet.com/journals/lan...
Acute kidney injury
Acute kidney injury (AKI) is a common, heterogeneous, multifactorial condition, which
is part of the overarching syndrome of acute kidney diseases and disorders. This condition's
incidence highest in ...
www.thelancet.com
January 21, 2025 at 1:39 AM
Review article on AKI: Lancet
This is a must-read paper that covers not only the epidemiology, pathophysiology, and management of AKI, but also crosstalk with other organs during the acute phase and long-term adverse effects on other organs.
www.thelancet.com/journals/lan...
This is a must-read paper that covers not only the epidemiology, pathophysiology, and management of AKI, but also crosstalk with other organs during the acute phase and long-term adverse effects on other organs.
www.thelancet.com/journals/lan...
Narrative review on vasoplegic shock
Regarding the dosage of norepinephrine used as a guideline for starting vasopressin therapy, there are an increasing number of publications stating "0.2 µg/kg/min" rather than "0.25 µg/kg/min."
www.bjaed.org/article/S205...
Regarding the dosage of norepinephrine used as a guideline for starting vasopressin therapy, there are an increasing number of publications stating "0.2 µg/kg/min" rather than "0.25 µg/kg/min."
www.bjaed.org/article/S205...
Management of vasoplegic shock
Vasoplegic shock is common, contributing up to two-thirds of cases of shock admitted
to the ICU.1,2 For the two most common causes of vasoplegic shock—septic shock and
vasoplegic shock after cardiopul...
www.bjaed.org
January 21, 2025 at 1:38 AM
Narrative review on vasoplegic shock
Regarding the dosage of norepinephrine used as a guideline for starting vasopressin therapy, there are an increasing number of publications stating "0.2 µg/kg/min" rather than "0.25 µg/kg/min."
www.bjaed.org/article/S205...
Regarding the dosage of norepinephrine used as a guideline for starting vasopressin therapy, there are an increasing number of publications stating "0.2 µg/kg/min" rather than "0.25 µg/kg/min."
www.bjaed.org/article/S205...
US assessment of LV function in septic shock
EF does not represent LV contractility but the relationship between LV contractility and afterload. For example, if there is too much vasopressor, the afterload will increase and EF may appear relatively low.
link.springer.com/article/10.1...
EF does not represent LV contractility but the relationship between LV contractility and afterload. For example, if there is too much vasopressor, the afterload will increase and EF may appear relatively low.
link.springer.com/article/10.1...
How we could use critical care echocardiography in the assessment of and management of cardiovascular phenotypes in septic shock: the good, the bad, and the ugly profiles - Intensive Care Medicine
Intensive Care Medicine -
link.springer.com
January 21, 2025 at 1:36 AM
US assessment of LV function in septic shock
EF does not represent LV contractility but the relationship between LV contractility and afterload. For example, if there is too much vasopressor, the afterload will increase and EF may appear relatively low.
link.springer.com/article/10.1...
EF does not represent LV contractility but the relationship between LV contractility and afterload. For example, if there is too much vasopressor, the afterload will increase and EF may appear relatively low.
link.springer.com/article/10.1...