Wiltgenlab
@wiltgenlab.bsky.social
Professor at UC Davis. Interested in neurobiological mechanisms of learning and memory.
Reposted by Wiltgenlab
I don't see a lot of people talking about this, so I want to highlight something GOOD
Billie Eilish stood in a room full of billionaires and said "you're billionaires... Why?"
She donated 11.5 MILLION DOLLARS to food equity and climate orgs, which Stephen Colbert announced to said billionaires.
Billie Eilish stood in a room full of billionaires and said "you're billionaires... Why?"
She donated 11.5 MILLION DOLLARS to food equity and climate orgs, which Stephen Colbert announced to said billionaires.
Billie Eilish Calls on Billionaires to Support People in Need: 'No Hate, But Give Your Money Away'
Billie Eilish donates $11.5 million from 'Hit Me Hard and Soft' tour to charity and calls on billionaires to support people in need during hard times.
www.rollingstone.com
October 30, 2025 at 3:56 PM
I don't see a lot of people talking about this, so I want to highlight something GOOD
Billie Eilish stood in a room full of billionaires and said "you're billionaires... Why?"
She donated 11.5 MILLION DOLLARS to food equity and climate orgs, which Stephen Colbert announced to said billionaires.
Billie Eilish stood in a room full of billionaires and said "you're billionaires... Why?"
She donated 11.5 MILLION DOLLARS to food equity and climate orgs, which Stephen Colbert announced to said billionaires.
Reposted by Wiltgenlab
Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)
www.sciencedirect.com/science/arti...
(1/2)
www.sciencedirect.com/science/arti...
Molecular mechanisms mediating engram ensemble retrievability state in mice
Engrams, ensembles of neurons that store memories, exist along a continuum of retrievability. Normally, sensory cues can reactivate a latent engram to…
www.sciencedirect.com
October 30, 2025 at 3:32 PM
Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)
www.sciencedirect.com/science/arti...
(1/2)
www.sciencedirect.com/science/arti...
Reposted by Wiltgenlab
New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
authors.elsevier.com
October 22, 2025 at 6:50 PM
New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
Reposted by Wiltgenlab
I am excited to share my PhD work on head-direction cells recorded in the wild, now published in @science.org, where we recorded neurons in bats flying outdoors on an island.
doi.org/10.1126/sci...
With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
doi.org/10.1126/sci...
With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
October 16, 2025 at 6:04 PM
I am excited to share my PhD work on head-direction cells recorded in the wild, now published in @science.org, where we recorded neurons in bats flying outdoors on an island.
doi.org/10.1126/sci...
With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
doi.org/10.1126/sci...
With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
Very interesting work by the Yin lab! 🤔
Really interesting work by Bakhurin and colleagues challenging the reward prediction error hypothesis of dopamine:
www.nature.com/articles/s41...
I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).
www.nature.com/articles/s41...
I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).
October 14, 2025 at 7:30 PM
Very interesting work by the Yin lab! 🤔
Reposted by Wiltgenlab
How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions: Trends in Neurosciences www.cell.com/trends/neuro...
How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions
The brain constantly generates predictions based on one’s knowledge of the world,
as captured in memory. When these predictions are in error, our knowledge base must
be revised to remain relevant. Her...
www.cell.com
October 4, 2025 at 3:17 PM
How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions: Trends in Neurosciences www.cell.com/trends/neuro...
Reposted by Wiltgenlab
New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows:
authors.elsevier.com/a/1lsO73QW8S...
authors.elsevier.com/a/1lsO73QW8S...
authors.elsevier.com
October 1, 2025 at 12:39 AM
New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows:
authors.elsevier.com/a/1lsO73QW8S...
authors.elsevier.com/a/1lsO73QW8S...
Reposted by Wiltgenlab
So proud🤩: Beautiful work by @clykken.bsky.social 💃🏻 et al: finally we understand how the hippocampus can express multiple maps even though grid cell inputs are universal metrics.
E.g. hippocampal global remapping was induced when different grid modules anchored independently to environments. See 👇🏽
E.g. hippocampal global remapping was induced when different grid modules anchored independently to environments. See 👇🏽
1/8
How can the brain create countless unique memories using a single, universal metric of space? We’ve been waiting for the answer to this for two decades!
Read it here:
www.biorxiv.org/content/10.1...
How can the brain create countless unique memories using a single, universal metric of space? We’ve been waiting for the answer to this for two decades!
Read it here:
www.biorxiv.org/content/10.1...
September 25, 2025 at 3:07 PM
So proud🤩: Beautiful work by @clykken.bsky.social 💃🏻 et al: finally we understand how the hippocampus can express multiple maps even though grid cell inputs are universal metrics.
E.g. hippocampal global remapping was induced when different grid modules anchored independently to environments. See 👇🏽
E.g. hippocampal global remapping was induced when different grid modules anchored independently to environments. See 👇🏽
Reposted by Wiltgenlab
When a typo in your Google search leads to new and exciting philosophical positions
September 22, 2025 at 9:25 PM
When a typo in your Google search leads to new and exciting philosophical positions
Reposted by Wiltgenlab
Thrilled to share that our work is now published in Science! ✨
We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭
www.science.org/doi/10.1126/...
🧵1/
We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭
www.science.org/doi/10.1126/...
🧵1/
September 11, 2025 at 8:14 PM
Thrilled to share that our work is now published in Science! ✨
We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭
www.science.org/doi/10.1126/...
🧵1/
We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭
www.science.org/doi/10.1126/...
🧵1/
Reposted by Wiltgenlab
MLK Jr. on violence:
September 10, 2025 at 7:45 PM
MLK Jr. on violence:
Reposted by Wiltgenlab
Mice are always smarter that we expect, here guessing the trail ahead rather than just blind following. Cool work:
We watched mice follow scent trails drawn on an “endless” treadmill. By manipulating trail geometry/statistics, perturbing mouse nose & brain, and modeling behavior with a Bayesian framework, we show that mice use predictive (rather than reactive) strategies.
September 1, 2025 at 7:12 PM
Mice are always smarter that we expect, here guessing the trail ahead rather than just blind following. Cool work:
Reposted by Wiltgenlab
When the PI hasn't worked in at the bench in years but needs to do something in the lab for a photoshoot
August 25, 2025 at 12:33 PM
When the PI hasn't worked in at the bench in years but needs to do something in the lab for a photoshoot
Green Day at Bottlerock 2025 🤘
May 24, 2025 at 10:44 PM
Green Day at Bottlerock 2025 🤘
Reposted by Wiltgenlab
I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. a🧵(1/8)
rdcu.be/el19t
rdcu.be/el19t
Prefrontal encoding of an internal model for emotional inference
Nature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.
rdcu.be
May 14, 2025 at 11:35 PM
I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. a🧵(1/8)
rdcu.be/el19t
rdcu.be/el19t
Reposted by Wiltgenlab
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested.
1/n
rdcu.be/el18q
A short thread follows for those interested.
1/n
Systems consolidation reorganizes hippocampal engram circuitry
Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...
rdcu.be
May 14, 2025 at 4:32 PM
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested.
1/n
rdcu.be/el18q
A short thread follows for those interested.
1/n
Reposted by Wiltgenlab
A wonderful day for science, to see the (peri) #LC in all its glory. A ginormous effort from all involved, and a fantastic resource for the field. Chapeau 🎩
🧠 🔵
www.nature.com/articles/s41...
🧠 🔵
www.nature.com/articles/s41...
Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours - Nature
A set of neurons in the peri-locus coeruleus region controls arousal and avoidance states, providing an understanding of the neurobiological basis of arousal and exploratory behaviours.
www.nature.com
May 7, 2025 at 8:37 PM
A wonderful day for science, to see the (peri) #LC in all its glory. A ginormous effort from all involved, and a fantastic resource for the field. Chapeau 🎩
🧠 🔵
www.nature.com/articles/s41...
🧠 🔵
www.nature.com/articles/s41...
Said goodbye to Ana and Cassiano last night. Best of luck in Brazil!!!
May 7, 2025 at 5:15 PM
Said goodbye to Ana and Cassiano last night. Best of luck in Brazil!!!
Reposted by Wiltgenlab
Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25
YouTube video by Steve Lawson
youtu.be
May 3, 2025 at 7:20 PM
Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
Reposted by Wiltgenlab
Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41...
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
April 9, 2025 at 6:28 PM
Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41...
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
Reposted by Wiltgenlab
Reposted by Wiltgenlab
It's the post-"standard model" age! Our Preview of a fantastic new study from Yi Zhong's lab on the role of the hippocampus in updating remote memories. Fun putting this together with Ali Golbabaei.
authors.elsevier.com/a/1kZ4f3BtfH...
authors.elsevier.com/a/1kZ4f3BtfH...
February 5, 2025 at 4:39 PM
It's the post-"standard model" age! Our Preview of a fantastic new study from Yi Zhong's lab on the role of the hippocampus in updating remote memories. Fun putting this together with Ali Golbabaei.
authors.elsevier.com/a/1kZ4f3BtfH...
authors.elsevier.com/a/1kZ4f3BtfH...
Reposted by Wiltgenlab
I’m old enough to remember when a person who dumped a dead bear cub in New York’s Central Park and tried to make it look like a bike accident might have trouble getting confirmed as Health and Human Services secretary.
February 4, 2025 at 6:22 PM
I’m old enough to remember when a person who dumped a dead bear cub in New York’s Central Park and tried to make it look like a bike accident might have trouble getting confirmed as Health and Human Services secretary.
Reposted by Wiltgenlab
1/19 I’m thrilled that my postdoctoral work, with John Widloski and David Foster is now out in @science.org, along with a wonderful preview by Daniel Bendor!
The time course and organization of hippocampal replay
The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content i...
www.science.org
January 31, 2025 at 9:14 PM
1/19 I’m thrilled that my postdoctoral work, with John Widloski and David Foster is now out in @science.org, along with a wonderful preview by Daniel Bendor!