Wanlu Zhang
@wanluzhang.bsky.social
Research Scientist @EllenbergLab @EMBL
Studying how nuclear pores assemble using super-resolution and electron microscopy.
Studying how nuclear pores assemble using super-resolution and electron microscopy.
Reposted by Wanlu Zhang
🎉Publication alert🎉
Congratulations to @lemkelab.bsky.social, @wittmann-lab.bsky.social, Girard Lab & their teams on their new Nature Communications publication. This work showcases the active cross-disciplinary dialogue that lies at the heart of our network. www.nature.com/articles/s41...
Congratulations to @lemkelab.bsky.social, @wittmann-lab.bsky.social, Girard Lab & their teams on their new Nature Communications publication. This work showcases the active cross-disciplinary dialogue that lies at the heart of our network. www.nature.com/articles/s41...
Differential conformational expansion of NUP98-HOXA9 oncoprotein from nanosized assemblies to macrophases - Nature Communications
Some transcription factors can organize into different structural states, from small nanoscale clusters to macrophases. Here authors show that NHA9 undergoes differential conformational expansion acro...
www.nature.com
November 18, 2025 at 3:30 PM
🎉Publication alert🎉
Congratulations to @lemkelab.bsky.social, @wittmann-lab.bsky.social, Girard Lab & their teams on their new Nature Communications publication. This work showcases the active cross-disciplinary dialogue that lies at the heart of our network. www.nature.com/articles/s41...
Congratulations to @lemkelab.bsky.social, @wittmann-lab.bsky.social, Girard Lab & their teams on their new Nature Communications publication. This work showcases the active cross-disciplinary dialogue that lies at the heart of our network. www.nature.com/articles/s41...
Reposted by Wanlu Zhang
We are very excited that our work on Torsins, dystonia and NE membrane fusion is out on bioRxiv: doi.org/10.1101/2025...
Fantastic collaboration with Madhav Jagannathan and the labs of Gautam Dey and Stefano Vanni!
Fantastic collaboration with Madhav Jagannathan and the labs of Gautam Dey and Stefano Vanni!
Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis
DYT1 early-onset dystonia is a severe, incurable disorder of the central nervous system caused by mutations in the gene encoding Torsin1A (Tor1A, DYT1). Torsins are ER-resident AAA+-ATPases implicated...
doi.org
November 10, 2025 at 8:54 AM
We are very excited that our work on Torsins, dystonia and NE membrane fusion is out on bioRxiv: doi.org/10.1101/2025...
Fantastic collaboration with Madhav Jagannathan and the labs of Gautam Dey and Stefano Vanni!
Fantastic collaboration with Madhav Jagannathan and the labs of Gautam Dey and Stefano Vanni!
Very happy to receive the Poster Prize at #EESImaging.
Huge thanks to everyone for the stimulating discussions and thoughtful feedback💡🔬✨!
Huge thanks to everyone for the stimulating discussions and thoughtful feedback💡🔬✨!
We're excited to announce the poster prize winners of #EESImaging 🔬
A special poster prize committee elected three winners:
Alara Kiris, @lumasullo.bsky.social and @wanluzhang.bsky.social. Congratulations!
Read on to learn about their research: s.embl.org/ees25-09post...
A special poster prize committee elected three winners:
Alara Kiris, @lumasullo.bsky.social and @wanluzhang.bsky.social. Congratulations!
Read on to learn about their research: s.embl.org/ees25-09post...
October 30, 2025 at 3:15 PM
Very happy to receive the Poster Prize at #EESImaging.
Huge thanks to everyone for the stimulating discussions and thoughtful feedback💡🔬✨!
Huge thanks to everyone for the stimulating discussions and thoughtful feedback💡🔬✨!
Reposted by Wanlu Zhang
A heartfelt thank you to everyone who attended #EESImaging 🙏
It was an enriching four-day symposium filled with high-level speakers, an enthusiastic crowd, fascinating insights, and amazing networking opportunities. We hope everyone found it beneficial and enjoyed the beautiful Heidelberg!
It was an enriching four-day symposium filled with high-level speakers, an enthusiastic crowd, fascinating insights, and amazing networking opportunities. We hope everyone found it beneficial and enjoyed the beautiful Heidelberg!
October 14, 2025 at 1:49 PM
A heartfelt thank you to everyone who attended #EESImaging 🙏
It was an enriching four-day symposium filled with high-level speakers, an enthusiastic crowd, fascinating insights, and amazing networking opportunities. We hope everyone found it beneficial and enjoyed the beautiful Heidelberg!
It was an enriching four-day symposium filled with high-level speakers, an enthusiastic crowd, fascinating insights, and amazing networking opportunities. We hope everyone found it beneficial and enjoyed the beautiful Heidelberg!
Reposted by Wanlu Zhang
This year’s Nobel Prize in Physiology or Medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering a class of immune cells that help to prevent the body from attacking its own tissues. #medsky 🧪
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
October 6, 2025 at 1:55 PM
This year’s Nobel Prize in Physiology or Medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering a class of immune cells that help to prevent the body from attacking its own tissues. #medsky 🧪
Reposted by Wanlu Zhang
“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.”
― Jane Goodall
💙 RIP to a real one. My childhood hero
― Jane Goodall
💙 RIP to a real one. My childhood hero
October 2, 2025 at 2:56 AM
“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.”
― Jane Goodall
💙 RIP to a real one. My childhood hero
― Jane Goodall
💙 RIP to a real one. My childhood hero
Excited to share the preprint from my postdoc work @ellenberglab.bsky.social! 🌟
During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...
During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...
Hydrophobic interactions of FG-nucleoporins are required for dilating nuclear membrane pores into selective transport channels after mitosis
Nuclear envelope (NE) reformation after mitosis is essential for daughter cell viability and requires tightly coordinated nuclear pore complex (NPC) assembly and nuclear membrane reformation. To revea...
doi.org
September 9, 2025 at 1:15 PM
Excited to share the preprint from my postdoc work @ellenberglab.bsky.social! 🌟
During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...
During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...
Reposted by Wanlu Zhang
Curious about RNA, aptamers, lipid membranes, molecular dynamics simulations, synthetic cells - and how these topics come together? Join @floppleton.bsky.social's talk in the unano webinar blogs.ed.ac.uk/unanowebinars
September 8, 2025 at 2:59 PM
Curious about RNA, aptamers, lipid membranes, molecular dynamics simulations, synthetic cells - and how these topics come together? Join @floppleton.bsky.social's talk in the unano webinar blogs.ed.ac.uk/unanowebinars
Reposted by Wanlu Zhang
If you are thinking about the future of structural biology, we are too! Our two cents (Jürgen Plitzko and I) just got published online here: authors.elsevier.com/sd/article/S...
August 23, 2025 at 11:21 PM
If you are thinking about the future of structural biology, we are too! Our two cents (Jürgen Plitzko and I) just got published online here: authors.elsevier.com/sd/article/S...
Reposted by Wanlu Zhang
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
ki.se/en/about-ki/...
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
ki.se
June 25, 2025 at 2:56 PM
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
ki.se/en/about-ki/...
Reposted by Wanlu Zhang
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
Reposted by Wanlu Zhang
Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX.
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
August 20, 2025 at 9:01 PM
Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX.
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
Reposted by Wanlu Zhang
🧪 Open PhD or Postdoc position 🧪
The project is in collaboration with my new collegue Miha Modic. If you are interesed in RNA modification, centromeres and bioinformatics this is for you!
Miha has more positions to fill, infos on his linkedin: linkedin.com/in/miha-modic-9aa8a752.
The project is in collaboration with my new collegue Miha Modic. If you are interesed in RNA modification, centromeres and bioinformatics this is for you!
Miha has more positions to fill, infos on his linkedin: linkedin.com/in/miha-modic-9aa8a752.
July 23, 2025 at 7:56 PM
🧪 Open PhD or Postdoc position 🧪
The project is in collaboration with my new collegue Miha Modic. If you are interesed in RNA modification, centromeres and bioinformatics this is for you!
Miha has more positions to fill, infos on his linkedin: linkedin.com/in/miha-modic-9aa8a752.
The project is in collaboration with my new collegue Miha Modic. If you are interesed in RNA modification, centromeres and bioinformatics this is for you!
Miha has more positions to fill, infos on his linkedin: linkedin.com/in/miha-modic-9aa8a752.
Reposted by Wanlu Zhang
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
www.nature.com
July 3, 2025 at 7:45 PM
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
Reposted by Wanlu Zhang
Static structures are out. A new publication from the Ellenberg lab ( @ellenberglab.bsky.social, @embl.org , @sfb1638.bsky.social ) and Andrej Sali shows how integrative spatiotemporal modeling captures molecular motion in 4D, unlocking dynamic views of nuclear pore complex assembly.
www.pnas.org
April 14, 2025 at 2:19 PM
Static structures are out. A new publication from the Ellenberg lab ( @ellenberglab.bsky.social, @embl.org , @sfb1638.bsky.social ) and Andrej Sali shows how integrative spatiotemporal modeling captures molecular motion in 4D, unlocking dynamic views of nuclear pore complex assembly.
Reposted by Wanlu Zhang
Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
How chromosomes shape up for cell division | EMBL
EMBL scientists have shown how overlapping loops of DNA stack upon each other in dividing cells to give rise to rod-shaped chromosomes
www.embl.org
March 24, 2025 at 3:10 PM
Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
🚨 Exciting Opportunity Alert! 🚨
The Ellenberg Lab is #hiring for two incredible postdoc/research scientist positions! Join the ERC-funded MITOFOLD project! 🧬
If you’re passionate about cutting-edge research and want to make a real impact, this is your chance! 🚀
The Ellenberg Lab is #hiring for two incredible postdoc/research scientist positions! Join the ERC-funded MITOFOLD project! 🧬
If you’re passionate about cutting-edge research and want to make a real impact, this is your chance! 🚀
We are #hiring!
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
March 19, 2025 at 12:03 PM
🚨 Exciting Opportunity Alert! 🚨
The Ellenberg Lab is #hiring for two incredible postdoc/research scientist positions! Join the ERC-funded MITOFOLD project! 🧬
If you’re passionate about cutting-edge research and want to make a real impact, this is your chance! 🚀
The Ellenberg Lab is #hiring for two incredible postdoc/research scientist positions! Join the ERC-funded MITOFOLD project! 🧬
If you’re passionate about cutting-edge research and want to make a real impact, this is your chance! 🚀
Reposted by Wanlu Zhang
My first own project is published:
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu
@wanluzhang.bsky.social
@wanluzhang.bsky.social
January 9, 2025 at 7:19 PM
My first own project is published:
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳