Some brilliant #MEdEd news. Roche announced statistically significant and clinically meaningful results from the phase III INShore study of Gazyva®/Gazyvaro® (obinutuzumab) in children and young adults (aged >= 2-25 years) with idiopathic nephrotic syndrome (INS).
We're running an uncontrolled experiment on Indian children's brains. Every cough syrup. Every appetite stimulant. Anticholinergics blocking neurotransmitters in developing brains. The worst part? We're doing it to calm OUR anxiety, not cure THEIR illness.👇
Caption: “Sex is a biological conversation.” Alt text: Microscopic view of immune and reproductive cells exchanging glowing chemical signals. Image prompt: “artistic rendering of immune cells and sperm communicating through streams of light particles.”
7️⃣ Different body sites, different conversations: Cervix and uterus = diplomacy. Rectum = defense. That’s why immune responses — and risks — differ by where semen lands.
5️⃣ Over time, that tolerance helps pregnancy succeed. Long-term partners? Lower risk of rejection-like immune issues (like pre-eclampsia). Your immune system prefers consistency.
4️⃣ The female body listens. Instead of attacking, it adapts. Regulatory T cells (Tregs) learn that partner’s antigens and build “tolerance memory.” Your immune system literally remembers who you’ve been with.
3️⃣ Those prostate molecules — TGF-β, PGE₂, IL-10 — are peacekeepers. They tell the receiving immune system: “Don’t attack. I come in peace.” Without that truce, fertilization would be a war.
2️⃣ Sperm aren’t lone travelers. They’re passengers in a biochemical potion called seminal plasma — rich in cytokines, growth factors, and immune-calming signals from the prostate.
1️⃣ Every time two people have sex, their immune systems meet. They exchange information — and if the bond lasts, the body learns that partner’s molecular signature. Not metaphor. Biology. #meded#medsky#TIL#science#biology
A mother was jailed for poisoning her child. Another child later revealed the truth. The machine hadn’t lied. It just couldn’t see. Read more 👇🏾 #medsky#meded open.substack.com/pub/vikkypae...
Interview with Eberechi Nwogu-Onyemkpa on integrating palliative care services and resources into the management of sickle cell disease. | New England Journal of Medicine www.nejm.org/do/10.1056/N...
I’m a pediatrician who loves the stories behind our festivals as much as those behind our pts. This #Deepavali, I trace the lamp back to its Sanskrit roots Padma Purāṇa to Guru Hargobind Ji. Read: “Diwali vs Deepāvali - the light behind the lamps.” 👇 open.substack.com/pub/vikkypae...
Ray Kurzweil predicts #AI will cure all diseases, merge our brains with the cloud, and multiply our intelligence a millionfold. He also has other interests..... Before we buy the vision, let's check who's selling it. New blog: 👇 open.substack.com/pub/vikkypae...
He made reels, quoted Power Star, fought monogenic SLE for a decade with a grin that refused to dim. His passing was expected. The heartbreak wasn’t. On René Leriche’s “small cemetery,” medical humility, and what my tradition taught me about what endures: substack.com/inbox/post/1...
When Trust Walks Away.....! The child we treated for systemic-onset JIA came back months later, worse but alive. We saved him again — and this time, maybe, saved their faith too! Read and share 👇 open.substack.com/pub/vikkypae... #meded#bioethics#medsky
The Goat, the Cloud, & the Science of Power. If handled well, India gains leverage as a data-rich, vaccine-producing power. If handled poorly, it becomes a supplier of raw genomic material for someone else’s innovation. Read More 👇 open.substack.com/pub/vikkypae... #meded#medsky#policy
The Silent Pulse: When Our Children Start Living with an Adult Disease. Because preventing a lifetime of disease can begin with one quiet reading, on one ordinary clinic day. Read More 👇 open.substack.com/pub/vikkypae...
