Sixteen-week dupilumab improved clinical outcomes in young children with AD, restoring skin barrier and suppressing local Th2 inflammation. However, persistent systemic inflammation suggests a need f...

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Heterogeneity among CRSwNP patients in Western and Eastern countries leads to differences in management. Type 2 (T2) inflammation accounts for the majority of CRSwNP patients in Western countries, wh...

Chronic rhinosinusitis (CRS) is driven by poorly understood immune-epithelial crosstalk. Liao et al. present a single-cell and spatial transcriptomic atlas of CRS, revealing how immune and epithelial ...

Mikrobiom Das Mikrobiom spielt eine entscheidende Rolle in der HNO-Heilkunde und beeinflusst sowohl lokale als auch systemische Gesundheit. Das aktuelle Themenheft beleuchtet, wie eine Dysbiose Infektionen und Tumoren fördern kann. Von zentraler Bedeutung sind dabei die mikrobielle Vielfalt und das Potenzial mikrobiommodulierender Maßnahmen zur Therapieverbesserung und Risikostratifizierung.

Constant loss of smell, facial pain and a blocked nose are a reality for the 10 per cent of people living with chronic rhinosinusitis, a disease long-neglected by research. Targeting the nasal microbiome, though, is offering hope

Background Emerging evidence suggests a possible link between rhinosinusitis and systemic rheumatic diseases; however, no meta-analysis has comprehensively examined this association to date. We aime...