Lars Teschke
@teschkel.bsky.social
Plant Science, Proteomics, Epigenetics & Epitranscriptomics
Reposted by Lars Teschke
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…
www.sciencedirect.com
September 24, 2025 at 3:30 PM
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Lars Teschke
Combining expansion microscopy with super-resolution radial fluctuations captures the morphology of single proteins go.nature.com/3Y1FD8M
rdcu.be/eI29D
rdcu.be/eI29D
One-step nanoscale expansion microscopy reveals individual protein shapes - Nature Biotechnology
Combining expansion microscopy with super-resolution radial fluctuations captures the morphology of single proteins.
go.nature.com
October 3, 2025 at 1:45 AM
Combining expansion microscopy with super-resolution radial fluctuations captures the morphology of single proteins go.nature.com/3Y1FD8M
rdcu.be/eI29D
rdcu.be/eI29D
Happy that I could contribute a tiny part to this amazing collaborative effort.
Online Now: A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity Online now:
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Fokkens et al. identify a eukaryotic module combining kinase and ubiquitin ligase domains. This module is part of a Leishmania virulence factor, TKUL, that requires both enzymatic activities and employs HSP70 adaptors for substrate ubiquitylation. This activity is allosterically controlled by the kinase, enabling suppression of ubiquitylation by kinase inhibitors.
dlvr.it
October 2, 2025 at 11:56 AM
Happy that I could contribute a tiny part to this amazing collaborative effort.
Reposted by Lars Teschke
From a gene’s single cell expression–through spatial localization–to novel function, and beyond!
Now out @natplants.nature.com
We built a comprehensive spatial-transcriptomic atlas of Arabidopsis, revealing cell-type identities across organs in unprecedented detail
www.nature.com/articles/s41...
Now out @natplants.nature.com
We built a comprehensive spatial-transcriptomic atlas of Arabidopsis, revealing cell-type identities across organs in unprecedented detail
www.nature.com/articles/s41...
A single-cell, spatial transcriptomic atlas of the Arabidopsis life cycle - Nature Plants
This study presents an extensive single-nucleus and spatial transcriptomic atlas of the Arabidopsis life cycle that represents ten distinct developmental time points inclusive of six diverse organs.
www.nature.com
August 19, 2025 at 7:20 PM
From a gene’s single cell expression–through spatial localization–to novel function, and beyond!
Now out @natplants.nature.com
We built a comprehensive spatial-transcriptomic atlas of Arabidopsis, revealing cell-type identities across organs in unprecedented detail
www.nature.com/articles/s41...
Now out @natplants.nature.com
We built a comprehensive spatial-transcriptomic atlas of Arabidopsis, revealing cell-type identities across organs in unprecedented detail
www.nature.com/articles/s41...