Thanks Misha for the shout-out!
It has been a truly mind-opening journey. WHOLISTIC is one step towards whole-organism neuroscience and a true physiological observatory - with extensions on the way! I am continually amazed by what the data reveals - so much remains to be discovered and mined.

New #Outlook #PsynomLB 'Emergence of orthogonal hippocampal representations during spatial learning' https://bit.ly/4mlOXQa by Prof. Vern Bingman @BGSU_Biology about the recent paper https://bit.ly/4jZO0eT by @sunw37 @JohanWinn @CornellNBB et al. @nature @Psychonomic_Soc

Excited to share our latest story! We found disentangled memory representations in the hippocampus that generalized across time and environments, despite the seemingly random drift and remapping of single cells. This code enabled the transfer of prior knowledge to solve new tasks

It was fun to visit Weinan's lab @sunw37.bsky.social at Cornell to give this talk. Exciting to see the experiments he's cooking up, and we had lots of fun discussions about PFC, hippocampus, consciousness and meditation!

Part of the talk content is here: blog.dileeplearning.com/p/space-is-a...

We read "Large Concept Models" in our reading group. It models language at the sentence resolution - "concepts". We had lots of thoughts about it! You can read them in our new Janelia CVML blog post:
janelia-cvml.github.io/blog/posts/L...
#ML #AI #Janelia @adjavon.bsky.social @bogovicj.bsky.social

(1/11) Today I preprinted a lot of work from my postdoc with @dudman.bsky.social, which started with a question of how the nervous system balances flexibility with efficiency of learning. The thread below gives some background....
www.biorxiv.org/content/10.1...

delighted to share our work revealing a new type of excitatory hippocampal neuron we call the "ovoid cell", which has really exquisite properties relative to adjacent pyramidal cells! superb work of first-author @adriennekinman.bsky.social and many others in the lab

www.nature.com/articles/s41...

#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41...

Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊

Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.

Paper here 👇
www.nature.com/articles/s41...

I’m excited about this collaborative project by @sunw37.bsky.social, @johanwinn.bsky.social, and many other talented contributors. Read about how our @hhmijanelia.bsky.social team imaged thousands of neurons in mouse hippocampus as mice learned cognitive tasks over several days: hhmi.news/4hXIp7r

Must-read for anyone interested in cognitive maps & the hippocampus.

Do I like this so much because it's a fantastic bit of science or because it's a fantastic job of doing science communication?!? Probably both. Regardless, awesome work that is worth checking out:)

Fantastic video explaining a study of hippocampal map formation.

Great fun!!!

1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...

Come lead a group at Janelia, be our neighbor. Nov 1 deadline for this round www.janelia.org/our-research...

My latest Substack post:

Can Large Language Models Reason?

aiguide.substack.com/p/can-large-...