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Reposted by Timothée Lionnet

Sheila Teves @sheilateves.bsky.social · 8d

How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.

Read it here 👉

www.biorxiv.org/content/10.1...

#MolecularEvolution #Transcription

Molecular determinants underlying functional divergence of TBP homologs

The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...

www.biorxiv.org

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Reposted by Timothée Lionnet

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 7d

👀

bioRxivpreprint @biorxivpreprint.bsky.social · 7d

Identification of human RNA Polymerase II interactors at early stages of transcription. https://www.biorxiv.org/content/10.1101/2025.10.08.681243v1

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Reposted by Timothée Lionnet

James Briscoe @jamesbriscoe.bsky.social · 9d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Reposted by Timothée Lionnet

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 13d

A printed human genome (displayed in the 'Medicine Now' room at the Wellcome Collection, London)

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Timothée Lionnet @successprocess.bsky.social · 16d

tl;dr it's all downhill from here

Julia M. Rohrer @dingdingpeng.the100.ci · 16d

Looks like my favorite paper on the age trajectory of happiness is finally out!!! So happy for the authors. Go check it out, it’s great.

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Reposted by Timothée Lionnet

Christophe 🔬 L @christlet.bsky.social · 20d

#FluorescenceFriday: getting ready for #GEF25, playing with Ciarán's stunning ExM data

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Reposted by Timothée Lionnet

Lucas Farnung @lucas.farnunglab.com · 20d

🚀 Ordering lab supplies just got way easier in our lab.
We built a workflow (github.com/farnunglab/N...) where tapping an NFC tag on a reagent bottle automatically triggers an order request in Quartzy. No more scribbling notes or hunting for a computer. Here’s how 👇

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Reposted by Timothée Lionnet

Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 20d

Back to work on #bigvolumebrowser, I've added the import of point clouds that change over time. The test data generation was a pleasant detour into the world of attractors (Thomas' cyclically symmetric is shown).

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Timothée Lionnet @successprocess.bsky.social · 20d

we could learn from other communities which have used preprints for longer - their preprints are usually much better formatted and easier to read

paveltomancak.bsky.social @paveltomancak.bsky.social · 20d

If we are to read exclusively pre-prints in the future, can we at least require to inline Figures with text? The pre-print format is all geared towards peer review, not the convenient presentation of the science.

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Reposted by Timothée Lionnet

Drug Monkey @drugmonkey.bsky.social · 20d

This may be the most important paper ever published about NIH funded research.

www.science.org/doi/10.1126/...

What if NIH had been 40% smaller?

Replaying history with less NIH funding shows widespread impacts on drug-linked research

www.science.org

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Reposted by Timothée Lionnet

John Greally @greally.bsky.social · 21d

Seven years.
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.

#EpigeneticsBook
@cshlpress.bsky.social

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Reposted by Timothée Lionnet

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 22d

Emergence of activation or repression in transcriptional control under a fixed molecular context www.pnas.org/doi/10.1073/...

Emergence of activation or repression in transcriptional control under a fixed molecular context | PNAS

Transcription factors (TFs) can be both activators and repressors of gene transcription. This can manifest as “duality,” where the transcriptional ...

www.pnas.org

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Reposted by Timothée Lionnet

Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 21d

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇

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Timothée Lionnet @successprocess.bsky.social · 22d

www.bbc.com/news/article...

www.bbc.com

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Reposted by Timothée Lionnet

Serena Sanulli Lab at Stanford Genetics @serenasanulli.bsky.social · 23d

Excited to share our first preprint! We developed an image-based pooled screen to uncover regulators of HP1 condensates and discovered a link with intronic RNA and RNA processing. 👏 Congrats to all authors, especially Matthew, Shaopu & Chris!

bioRxiv Genetics @biorxiv-genetic.bsky.social · 24d

An image-based CRISPR screen reveals splicing-mediated control of HP1α condensates https://www.biorxiv.org/content/10.1101/2025.09.21.676939v1

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Reposted by Timothée Lionnet

Slavov Laboratory @slavovlab.bsky.social · 25d

We quantified mRNA abundance, translation, protein abundance, protein degradation and cell growth across thousands of single cells from a mammalian tissue.

The results revealed 𝐜𝐨𝐦𝐩𝐥𝐞𝐱 regulation & 𝐬𝐢𝐦𝐩𝐥𝐞 organizing principles:

www.biorxiv.org/content/10.1...

🧵

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Reposted by Timothée Lionnet

Anders Sejr Hansen @andersshansen.bsky.social · 24d

Asking BlueSky for help: For a review, I am trying to accurately credit the first paper that measured pairwise 3D distances between 2 pieces of DNA on the same chromosome (or cosmid). Is Trask 1989 the first?
I know of earlier single-locus papers (1982).
www.sciencedirect.com/science/arti...

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Reposted by Timothée Lionnet

siddhartha jena @epijenatics.bsky.social · Sep 11

Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9

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Reposted by Timothée Lionnet

Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · Sep 11

Really enjoying reading this primer on single particle tracking #microscopy by @svanteeffelen.bsky.social and colleagues www.nature.com/articles/s43... (pdf on Sven's website)

A guide to single-particle tracking - Nature Reviews Methods Primers

Single-particle tracking is a method for analysing different motion behaviours of individual proteins and protein complexes in live cells. This Primer outlines the experimental setup and labelling tec...

www.nature.com

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Reposted by Timothée Lionnet

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Sep 11

👀

Multiple human enhancer RNAs contain long translated open reading frames

genesdev.cshlp.org/content/earl...

Multiple human enhancer RNAs contain long translated open reading frames

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

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Reposted by Timothée Lionnet

Pedro Rocha @pedroprocha.bsky.social · Sep 8

🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...

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Reposted by Timothée Lionnet

Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · Sep 8

Become our colleague at @fmiscience.bsky.social! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!

FMI science @fmiscience.bsky.social · Sep 8

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

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Timothée Lionnet @successprocess.bsky.social · Sep 2

looks like this would only apply for institutions with endowments > 500k per student? www.law.cornell.edu/uscode/text/...

26 U.S. Code § 4968 - Excise tax based on investment income of private colleges and universities

www.law.cornell.edu

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Reposted by Timothée Lionnet

Dr. David Miller 🏳️‍🌈 @davidimiller.bsky.social · Sep 1

🧪 And House appropriators say: no cuts to NIH budget!

House subcommittee version just came out (link below). Holds NIH flat at $48 billion.

To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.

YOUR VOICE MATTERS!!

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Timothée Lionnet @successprocess.bsky.social · Aug 31

I just love the esthetics of those old school drawn figures of cells

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