Stefan Köstler
@stefankoestler2025.bsky.social
54 followers 130 following 8 posts
PhD Candidate @zwickergroup.bsky.social & IMPRS-PBCS Fellow, studying the dynamics of active droplets. https://sites.google.com/view/stefan-koestler
Posts Media Videos Starter Packs
Pinned
New preprint 🥳
In our new paper, we show that “Advection selects pattern in multi-stable emulsions of active droplets” — which provides a path toward controlling regular arrangements of droplets. 🧵
📄 arxiv.org/abs/2510.00827
Reposted by Stefan Köstler
Good news in rough times:
Our work on generalising Lifshitz-Slyosov-Wagner (LSW) theory to active systems, led by the all-mighty Jonathan Bauermann, is out on PRL!! Special thanks to Christoph Weber @m-pol.bsky.social and Frank Jülicher.

doi-org.sire.ub.edu/10.1103/f5x9...
🔬 This mechanism could be vital in biological cells to control condensates. Similarly, this method could allow creating micro-reactors for chemical assembly in synthetic applications or facilitate localized enzymatic activity for biomedical applications.
Taken together, advection modulates the initial dynamics — essentially independent of reactions — and biases the overall system toward a particular configuration, which is then maintained by reactions.
Interestingly, we find that multiple pattern sizes around the predicted one are stable!
Linear stability analysis reveals that emulsions become stable against Ostwald ripening from a minimal pattern size onwards.
Reactions arrest coarsening (left)
Advection accelerates early coarsening (right)

👉 We numerically and analytically determine the final equilibrium pattern size using a mapping to an equilibrium system.
👉 Looking at dissipation, we observe that advection peaks in early stages of coarsening.
New preprint 🥳
In our new paper, we show that “Advection selects pattern in multi-stable emulsions of active droplets” — which provides a path toward controlling regular arrangements of droplets. 🧵
📄 arxiv.org/abs/2510.00827
Reposted by Stefan Köstler
New preprint 🎉
What began as Frieder Johannsen’s bachelor thesis in the @zwickergroup.bsky.social (which I had the pleasure to supervise) evolved into our latest paper: “Chemically Active Liquid Bridges Generate Repulsive Forces” — unlike passive ones, which attract.
📄 arxiv.org/abs/2509.18777
Reposted by Stefan Köstler
“Journals and peer review are unlikely to change for the better if the companies that operate scientific indexes and citation databases continue to stifle innovation.”

Read our guest post in DORA: buff.ly/EGDbskH
Reposted by Stefan Köstler
Our institute turned 100 years today! We had a fantastic celebration with scientific talks by Howard Stone and Christina Marchetti. 🎉
Das Max-Planck-Institut für Dynamik und Selbstorganisation in Göttingen feiert am 16. Juli seinen 100. Geburtstag. Ein Blick auf die Geschichte des Instituts und die Verantwortung, die daraus erwächst. www.mpg.de/25050354/100... #Wissenschaftsgeschiche #Physik
Große Physik und große Verantwortung
Vor hundert Jahren nahm das Kaiser-Wilhelm-Institut für Strömungsforschung seine Arbeit auf. Aus ihm wurde das heutige Max-Planck-Institut für Dynamik und Selbstorganisation, das grundlegende Fragen d...
www.mpg.de
Reposted by Stefan Köstler
And that concludes our #kitp program on biomolecular condensates 😢 Wow, what an *incredible* experience, and unique place to learn and think and grow! 🤓
Reposted by Stefan Köstler
Can't say enough about the Condensates program at @kitp-ucsb.bsky.social. Invigorating discussions, fantastic facilities, and a beautiful location (a place I consider "home"). Thanks to @weber-lab.bsky.social, @jerelleaj.bsky.social, @zwickergroup.bsky.social, and Frank Julicher for organizing!
Just leaving Paris after 3 weeks of summer school on combining maths and physics to tackle #ActiveMatter.
I gained new perspectives, met wonderful people and had fascinating discussions. It was great to communicate my research to so many interested people!
And of course, Paris was just wonderful!
Reposted by Stefan Köstler
@jerelleaj.bsky.social, master painter 👩🏽‍🎨 of the blackboard 👩🏽‍🏫, in action! 🤩 She is amazing at capturing the essence of our complex, meandering (and sometimes contentious) discussions @kitp-ucsb.bsky.social
Reposted by Stefan Köstler
It’s been a lot of fun talking about chemically active condensates to such an attentive and motivated crowd!
David @zwickergroup.bsky.social gives the first tutorial of the biomol25 program @kitp-ucsb.bsky.social, reminding us that phase equilibria and chemical equilibria are coupled by thermodynamics
Reposted by Stefan Köstler
We updated our pre-print on equilibria in multicomponent mixtures: arxiv.org/abs/2405.01138 In particular, we added the figure below, which shows that such mixtures exhibit countless metastable states between a metastable homogeneous state and the equilibrium with many phases.
Reposted by Stefan Köstler
Huge thanks to all the incredible speakers who have shared their research at the Young Biophysicists Meeting so far!

Here's a glimpse.

See you in the next session!
Reposted by Stefan Köstler
I am looking forward to tell you about my research at #DPG. Come by my poster on wednesday to learn how coarsening of active droplets can be controlled by active reactions!
Excited for the #DPG meeting in Regensburg this week! Our group has a number of contributions across various sections. We look forward to discuss our science with you!
A list of all contributions of the Zwicker Group at the meeting. Details at https://www.dpg-verhandlungen.de/year/2025/conference/regensburg/search?query=David+Zwicker&submit=Suchen
Reposted by Stefan Köstler
We have an open postdoc position in our group! We seek motivated and fun people with a background in theoretical biological physics to work on projects revolving around pattern formation, cell biology, and particularly #condensates. Details: www.ds.mpg.de/4078435/job_...

#TheoBiophysicsPosition
Postdoctoral Position (m/f/d) | Biological Physics
For the independent research group “Theory of Biological Fluids” headed by Dr. David Zwicker we seek to fill a Postdoctoral Position (m/f/d) in Biological Physics.
www.ds.mpg.de
Reposted by Stefan Köstler
We published a one-page article in Nat. Chem. Eng. on phase separation in multicomponent mixtures: rdcu.be/ea4Ts

The article exposes our latest results, which indicate such mixtures are generically multistable and imply that states with various different droplets (or none at all) are all stable.
To mix or not to mix?
Nature Chemical Engineering - David Zwicker discusses the delicate balance between entropy and enthalpy that determines whether fluids comprising many components mix or phase separate.
rdcu.be
Reposted by Stefan Köstler
We wrote a review on the "Physics of droplet regulation in biological cells": arxiv.org/abs/2501.13639 Beside the basic #physics of phase separation, we discuss three aspects that separate cellular from traditional droplets:
A schematic picture of a cell, showing condensates, a nucleus and the cytoskeleton.
Reposted by Stefan Köstler
We just updated our preprint on size-control of condensates by electrostatic effects: arxiv.org/abs/2409.15599 This joint work with the group of @jerelleaj.bsky.social shows that electrostatic effects matter, even when one would naively expect that screening by salt is strong.
Condensate Size Control by Net Charge
Biomolecular condensates are complex droplets comprising diverse molecules that interact using various mechanisms. Condensation is often driven by short-ranged attraction, but net charges can also med...
arxiv.org