Stáňa Martínková
@stanam.bsky.social
Assistant Professor at the Faculty of Medicine/pancreatic cancer researcher/tumor microenvironment/organoids/TNTs/metabolism/reproductive biology
Zooming 🍀 into the Šumava National Park, Czech Republic
August 22, 2025 at 8:06 PM
Zooming 🍀 into the Šumava National Park, Czech Republic
Reposted by Stáňa Martínková
Hello World !
Super pleased to annonce that this account is now the official page to follow the STEMDORADO science magazine!
We are a FREE and independent science magazine for kids aged 6–14 published every other month authored by researchers across UK's leading institutions, access for free here:
Super pleased to annonce that this account is now the official page to follow the STEMDORADO science magazine!
We are a FREE and independent science magazine for kids aged 6–14 published every other month authored by researchers across UK's leading institutions, access for free here:
STEM Dorado Science | Stem Dorado
www.stemdorado.com
August 8, 2025 at 11:38 AM
Hello World !
Super pleased to annonce that this account is now the official page to follow the STEMDORADO science magazine!
We are a FREE and independent science magazine for kids aged 6–14 published every other month authored by researchers across UK's leading institutions, access for free here:
Super pleased to annonce that this account is now the official page to follow the STEMDORADO science magazine!
We are a FREE and independent science magazine for kids aged 6–14 published every other month authored by researchers across UK's leading institutions, access for free here:
Reposted by Stáňa Martínková
Our significantly expanded preprint is out. In it we show that pancreatic cancer cells can transfer ribosomes via tunnelling nanotubes and rescue protein synthesis when co-cultured with cells with impaired ribosomal biogenesis.
🧪
(Includes some #bayesian #rstats inspired by @rmcelreath.bsky.social)
🧪
(Includes some #bayesian #rstats inspired by @rmcelreath.bsky.social)
Ribosome transfer via tunnelling nanotubes rescues protein synthesis in pancreatic cancer cells
Background: Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the deadliest types of cancer. Tunnelling nanotubes (TNTs) are thin, membranous, intercellular communication structures obse...
www.biorxiv.org
August 6, 2025 at 7:56 AM
Our significantly expanded preprint is out. In it we show that pancreatic cancer cells can transfer ribosomes via tunnelling nanotubes and rescue protein synthesis when co-cultured with cells with impaired ribosomal biogenesis.
🧪
(Includes some #bayesian #rstats inspired by @rmcelreath.bsky.social)
🧪
(Includes some #bayesian #rstats inspired by @rmcelreath.bsky.social)
Reposted by Stáňa Martínková
Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis
https://go.nature.com/46c474I
https://go.nature.com/46c474I
Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature
A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.
go.nature.com
June 25, 2025 at 4:31 PM
Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis
https://go.nature.com/46c474I
https://go.nature.com/46c474I
Insightful research article 🍀 www.science.org/doi/10.1126/...
Tunneling nanotube–like structures regulate distant cellular interactions during heart formation
In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morpho...
www.science.org
May 1, 2025 at 6:15 AM
Insightful research article 🍀 www.science.org/doi/10.1126/...
Reposted by Stáňa Martínková
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress
Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.
www.science.org
April 18, 2025 at 10:56 PM
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Reposted by Stáňa Martínková
ThermoFisher tell us their CellTracker dyes are not transferred to neighbouring cells but we see significant transfer @24h when we mix stained with unstained cells. Any suggestions how to label cells reliably so that we can track distinct populations with no or minimal transfer? 🧪 #fluorescence
April 11, 2025 at 11:55 AM
ThermoFisher tell us their CellTracker dyes are not transferred to neighbouring cells but we see significant transfer @24h when we mix stained with unstained cells. Any suggestions how to label cells reliably so that we can track distinct populations with no or minimal transfer? 🧪 #fluorescence
Reposted by Stáňa Martínková
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
February 3, 2025 at 7:38 AM
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Stáňa Martínková
A new mechanism for cancer-induced immune evasion. We knew about cancer cells hijacking mitochondria. Now we learn about how their mitochondrial transfer to T cells impairs the tumor immune response.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
January 22, 2025 at 4:39 PM
A new mechanism for cancer-induced immune evasion. We knew about cancer cells hijacking mitochondria. Now we learn about how their mitochondrial transfer to T cells impairs the tumor immune response.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Reposted by Stáňa Martínková
Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.
December 20, 2024 at 11:18 AM
Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.
A quick snapshot from a fluorescence microscope, taken during a teaching session with medical students, showcased the fascinating world of mitochondria. The students were excited, asking many questions about why cells transfer mitochondria (MitoTracker-Red) via tunneling nanotubes (actin-green).
December 11, 2024 at 3:50 AM
A quick snapshot from a fluorescence microscope, taken during a teaching session with medical students, showcased the fascinating world of mitochondria. The students were excited, asking many questions about why cells transfer mitochondria (MitoTracker-Red) via tunneling nanotubes (actin-green).
Reposted by Stáňa Martínková
#TunnelingNanotubes are long filamentous actin-based cell protrusions that create communication networks between cells, especially in cancer. Here, an especially long nanotube transmits GFP-expressing oncolytic virus, a mechanism for propagation of the bystander effect.
www.cell.com/molecular-th...
www.cell.com/molecular-th...
November 18, 2024 at 2:12 AM
#TunnelingNanotubes are long filamentous actin-based cell protrusions that create communication networks between cells, especially in cancer. Here, an especially long nanotube transmits GFP-expressing oncolytic virus, a mechanism for propagation of the bystander effect.
www.cell.com/molecular-th...
www.cell.com/molecular-th...