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Julie Kovacs @juliekovacs.bsky.social · 1d

"The pause has many academic researchers feeling anxious. The timing couldn’t be worse for Julie Kovacs, a bioinorganic chemist at the University of Washington (UW) whose grant proposal was slated to be reviewed on 23 October. Even if the... 1/2

www.science.org/content/arti...

As U.S. shutdown drags on, ‘it’s just one blow after another’

Federal researchers confront growing uncertainty about future

www.science.org

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SmithLabUMBC @smithlabumbc.bsky.social · 1d

Hopefully they are giving you a discount as the lifetime of the source continues to decrease!! 😬

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 5d

👏 👏 👏

orgchart.mit.edu/letters/rega...

Regarding the Compact | MIT Organization Chart

The U.S. Department of Education recently sent MIT and eight other institutions a proposed “Compact for Academic Excellence in Higher Education," along with a letter asking that MIT review the document.

orgchart.mit.edu

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Structural Biology @actacrystd.iucr.org · 6d

Unintended proteins can easily sneak into experiments, but cryo-EM shows surprising power to uncover these `off-target' proteins in great detail #CryoEM #ArnA #AcrB doi.org/10.1107/S205...

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Structural Biology @actacrystd.iucr.org · 6d

Gayathri Yuvaraj et al.: Critical evaluation of three cryo-EM structures of particulate methane monooxygenase by quantum refinement ##QuantumRefinement##CryogenicElectronMicroscopy@lundsuni...##IUCrhttps://journals.iucr.org/paper?S2059798325008356

Critical evaluation of three cryo-EM structures of particulate methane monooxygenase by quantum refinement

We have studied the copper sites in three cryogenic electron-microscopy structures of particulate methane monooxygenase with quantum refinement. We show that the CuA, CuC and CuD sites are correctly modelled and that the CuB site is mononuclear in all structures, whereas we find no support for copper in the suggested trinuclear active site or two sites in the so-called copper sponge in PDB entry 7ev9.

journals.iucr.org

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SmithLabUMBC @smithlabumbc.bsky.social · 7d

Hey, that's us! 😀

UW–Madison Department of Biochemistry @uwbiochem.bsky.social · 7d

Join us on Monday Oct. 13 for Biochemistry Colloquium with Aaron Smith! Research in Smith's lab focuses on understanding the structure and function of metalloproteins involved in crucial biological processes. More info: today.wisc.edu/events/view/...

Biochemistry Colloquium: Aaron T. Smith | UW–Madison Events Calendar

today.wisc.edu

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bioRxivpreprint @biorxivpreprint.bsky.social · 8d

The structure of the full catalytic cycle of Vibrio cholerae NFeoB https://www.biorxiv.org/content/10.1101/2025.10.06.680749v1

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SmithLabUMBC @smithlabumbc.bsky.social · 8d

🚨 Just out in @biorxivpreprint.bsky.social 🚨 Kate, Candice, and Mark's paper on the structure of the V. cholerae NFeoB NTPase catalytic cycle. Serendipity of a P1 spacegroup with 4 mols in the ASU played a role in capturing all the states, and Mg is pivotal! Read the paper here: tinyurl.com/263u9vtn

The structure of the full catalytic cycle of Vibrio cholerae NFeoB

The acquisition of iron is critical for the survival and the virulence of numerous infectious pathogens, and most bacteria acquire ferrous iron (Fe2+) by utilizing the ferrous iron transport (Feo) sys...

tinyurl.com

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SmithLabUMBC @smithlabumbc.bsky.social · 11d

And let's not forget the "oh our grad program is special so we don't accept letters but instead here's a 100 question census of the applicant; please rank the applicant whether they are 'extra special', 'extra, extra special,' 'once in a lifetime talent,' or 'once in a century talent'?

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SmithLabUMBC @smithlabumbc.bsky.social · 12d

A great opportunity to work with a great mentor!

HematianLab @hematianlab.bsky.social · 12d

For our lab at Virginia Tech, we are hiring a postdoctoral scholar to advance catalytic and energy storage systems. This is a collaborative project, and expertise in synthesis, photocatalysis, electrochemistry, or energy storage is ideal. For details see here: spartantalent.uncg.edu/postings/32936

The pictures of the research team and collaborators.

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SmithLabUMBC @smithlabumbc.bsky.social · 16d

Someone got pooped from helping us decorate for Halloween…🎃

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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 18d

🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…

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SmithLabUMBC @smithlabumbc.bsky.social · 19d

Not safe. Needs to add three-factor authentication...🫠

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Drug Monkey @drugmonkey.bsky.social · 19d

The NSF GRFP is now limited to undergrads and first-year grads drugmonkey.wordpress.com/2025/09/26/t...

The NSF GRFP is now limited to undergrads and first-year grads

The solicitation for the 2025 submission dates for the NSF Graduate Research Fellowship Program is out, with the first deadline of November 10 for life-sciences disciplines. The big news is that el…

drugmonkey.wordpress.com

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Drug Monkey @drugmonkey.bsky.social · 20d

This may be the most important paper ever published about NIH funded research.

www.science.org/doi/10.1126/...

What if NIH had been 40% smaller?

Replaying history with less NIH funding shows widespread impacts on drug-linked research

www.science.org

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SmithLabUMBC @smithlabumbc.bsky.social · 21d

@rajat-jha.bsky.social

getacrystal @getacrystal.bsky.social · 21d

Not being able to crystallize your biomolecule of interest?

Now that's scary. 😱
Try our high-throughput screen!
October 2025 Soluble (taking reservations)

Reservation Deadline: Fri Oct 3rd
Package Acceptance & Plate Setup:
Tues Oct 7th – Thurs Oct 9th
Tues Oct 14th – Thurs Oct 16th

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perlstein.bsky.social @perlstein.bsky.social · 26d

New paper alert! We ID resides of CIA targeting complex that recruit clients - in contradiction to what was predicted from previous studies, we find it is the cia1-cia2 interface, not cia1 on its own, that mediates the interaction.

pubs.acs.org/doi/10.1021/...

A Conserved Cia1–Cia2 Interface Mediates Client Recruitment in the Cytosolic Iron–Sulfur Cluster Assembly Pathway

The cytosolic iron–sulfur cluster assembly (CIA) targeting complex maturates over 30 cytosolic and nuclear Fe–S proteins, raising the question of how a single complex recognizes such a diverse set of ...

pubs.acs.org

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Chris Chang @christhechang.bsky.social · 27d

Copper regulates the evolution of REM sleep and transition of animals from water to land! It all relies on a new “metalloadaptor” function for RAD23B linking Cu uptake to distribution to multiple Cu targets. Tong and Dan co-led this @cp-molcell.bsky.social story www.sciencedirect.com/science/arti...

RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity

Increasing brain complexity is a major step in the evolution of species. Here, we show that, in the transition from amphibians to reptiles, the DNA re…

www.sciencedirect.com

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SBGrid Consortium @sbgrid.bsky.social · 28d

SBGrid's eLife paper received a citation in August from @fisherlab.bsky.social at @wesleyanuniversity.bsky.social in Journal of Biological Chemistry: Copper acquisition in Bacillus subtilis involves Cu(II) exchange between YcnI and YcnJ.

Read more here: buff.ly/myITTv8

#SBGrid #ScienceMatters

Copper acquisition in Bacillus subtilis involves Cu(II) exchange between YcnI and YcnJ

The transition metal copper (Cu) is biologically essential across all three domains of life. Several Cu-dependent proteins and enzymes produced by the Gram-positive bacterium Bacillus subtilis have…

buff.ly

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International Society for Protein Termini (ISPT) @ispt-proteinterm.bsky.social · 28d

New review on the generation and consequences of N-terminal proteoform diversity from Evan Morrison and Olivia Rissland | #N-degron #RNA @cp-cellreports.bsky.social www.sciencedirect.com/science/arti...

The generation and consequences of N-terminal proteoform diversity

N-terminal proteoforms are protein variants with altered N termini that arise from RNA-driven processes, such as alternative promoter usage, splicing,…

www.sciencedirect.com

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Ákos T Kovács @evolvedbiofilm.bsky.social · Sep 12

See our @natmicrobiol.nature.com News&Views on the publication from Yun Chen laboratory

A rapid writing exercise for María Negre Rodríguez, a PhD student in my group

Ecological function of phenazine in soil
www.nature.com/articles/s41...

#MicrobiomeEcology at #LeidenBiology

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Laura M. K. Dassama @lmkdassama.bsky.social · Sep 6

@jonathanccc-chem.bsky.social's predictor for discovering lipid interacting proteins is now in press - congratulations to all the authors!. We are delighted that SLiPP has spurred so many new research directions in the lab and nucleated many collaborations! pubs.acs.org/doi/10.1021/...

A Machine Learning Model for the Proteome-Wide Prediction of Lipid-Interacting Proteins

Lipids are essential metabolites that play critical roles in multiple cellular pathways. Like many primary metabolites, mutations that disrupt lipid synthesis can be lethal. Proteins involved in lipid...

pubs.acs.org

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MiTeGen @mitegen.com · Sep 5

The 4th Annual Early Career Symposium at IBBR is Sept. 17th - Its a forum for graduate students & post-docs to share their scientific research in the fields of disease biology & biotherapeutics development & analysis - zurl.co/4oUyS We are sponsoring & exhibiting there

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sarahejbowman @xtalmaker.bsky.social · Sep 4

Exciting news 🎉! Notice of Award from NIH National Institute of General Medical Sciences (NIGMS) for a new instrument in the National Crystallization Center! Stay tuned for more details... hint: 🦟 🤖
@getacrystal.bsky.social

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SmithLabUMBC @smithlabumbc.bsky.social · Sep 3

JFC:

www.cnn.com/2025/09/03/h...

Florida plans to end vaccine mandates statewide | CNN

Florida will move to end all vaccine mandates in the state, Florida Surgeon General Dr. Joseph Ladapo announced Wednesday.

www.cnn.com