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Sixten Harborg, MD @sixtenharborg.bsky.social · May 17

Happy to see the @breastcancerorg.bsky.social highlighting our study presented at the #ESMOBreast2025 🔬

Breastcancer.org @breastcancerorg.bsky.social · May 17

At #ESMOBreast2025, @sixtenharborg.bsky.social
shared a significant analysis from the Nurses’ Health Study showing that weight gain after diagnosis may raise #breastcancer death risk. Study followed 6,800+ women between 1978 - 2018, with follow-up ranging from 4–15 years.
🔗http://bit.ly/ESMO2025

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Reposted by Sixten Harborg, MD

Breastcancer.org @breastcancerorg.bsky.social · May 17

At #ESMOBreast2025, @sixtenharborg.bsky.social
shared a significant analysis from the Nurses’ Health Study showing that weight gain after diagnosis may raise #breastcancer death risk. Study followed 6,800+ women between 1978 - 2018, with follow-up ranging from 4–15 years.
🔗http://bit.ly/ESMO2025

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Reposted by Sixten Harborg, MD

Journal of Internal Medicine @jinternmed.bsky.social · Jan 31

Follow the discussion! #Obesity treatment in #adolescents and adults in the era of personalized medicine

➡️The treatment arsenal has never been more diverse than now

🔹Review: doi.org/10.1111/joim.13816
🔹Regarding: doi.org/10.1111/joim.20063
🔹Authors reply: doi.org/10.1111/joim.20062

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Sixten Harborg, MD @sixtenharborg.bsky.social · Jan 8

#bcsm #OncSky #MedSky #metabolicsyndrome #cancersky #cansky @oncoalert.bsky.social @oncodaily.bsky.social
@aarhusuni.bsky.social @lunduniversity.bsky.social

Sixten Harborg, MD @sixtenharborg.bsky.social · Jan 8

Based on our findings and others, we propose that research is warranted into whether BC survivors might benefit from metabolic screening during their treatment course to improve their chances of avoiding a recurrence or death from their malignancy 🔬🧪🧑‍🔬

Sixten Harborg, MD @sixtenharborg.bsky.social · Jan 8

More research is needed ❗️

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Sixten Harborg, MD @sixtenharborg.bsky.social · Jan 8

The molecular changes affecting breast cancer progression in women with metabolic syndrome are complex

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Sixten Harborg, MD @sixtenharborg.bsky.social · Jan 8

Recurrence and BC mortality 📈

Our analyses show that the presence of metabolic syndrome among BC survivors is equally harmful in people living in Europe, Asia or North America 🌍

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Sixten Harborg, MD @sixtenharborg.bsky.social · Jan 8

🚨PUBLISHED🚨

In an extensive effort to chart the impact of living with metabolic syndrome among BC survivors we conducted a large meta-analysis of >42,000 patients.

We found that BC survivors living with metabolic syndrome had shorter DFS 📉 and increased risk of….

Journal of Internal Medicine @jinternmed.bsky.social · Jan 8

Metabolic syndrome increases the risk for breast cancer events!

🚨 A meta-analysis reveals a 69% higher recurrence risk & 83% higher mortality risk in BC survivors with metabolic syndrome.

➡️ Is it time to prioritize metabolic health in BC care?

🔗 doi.org/10.1111/joim.20052

#bcsm #cancer

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Reposted by Sixten Harborg, MD

Journal of Internal Medicine @jinternmed.bsky.social · Jan 8

Metabolic syndrome increases the risk for breast cancer events!

🚨 A meta-analysis reveals a 69% higher recurrence risk & 83% higher mortality risk in BC survivors with metabolic syndrome.

➡️ Is it time to prioritize metabolic health in BC care?

🔗 doi.org/10.1111/joim.20052

#bcsm #cancer

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Reposted by Sixten Harborg, MD

Maryam Lustberg MD MPH FASCO @maryamlustberg.bsky.social · Dec 20

@cancercaremascc.bsky.social webinar today with Amy Comander and @raalbany.bsky.social

#bcsm #supponc

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Reposted by Sixten Harborg, MD

Erika Hamilton MD, FASCO @erikahamilton9.bsky.social · Dec 12

It's a difficult topic to discuss- weight. Hugely personal, not easy to change, but impt.

4% ⬆️ recurrence in pts w/ node + #bcsm obese vs. lean

2% ⬆️ recurrence in pts with N0 dz

📌Magnitude of effect larger among premeno.

📌ER + AND ER neg

@sabcs.bsky.social
#SABCS24
@oncoalert.bsky.social

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Sixten Harborg, MD @sixtenharborg.bsky.social · Dec 12

#SABCS24 #bcsm #OncSky #MedSky

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Sixten Harborg, MD @sixtenharborg.bsky.social · Dec 12

The discussion turns towards a wish of longitudinal weight measures during follow-up 📊

Sixten Harborg, MD @sixtenharborg.bsky.social · Dec 12

Beautifully depicted work on obesity and risk of distant recurrence in BC pts by EBCTCG👏🏻

Across data from 147 including 200.000+ pts they demonstrated that BMI is independently associated with risk of distant recurrence regardless of treatment characteristics📈

@sabcs.bsky.social

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Sixten Harborg, MD @sixtenharborg.bsky.social · Dec 12

#SABCS24 #bcsm #OncSky #MedSky

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Sixten Harborg, MD @sixtenharborg.bsky.social · Dec 12

Thank you so much! It was great chatting with you too and thank you for sharing your insights.

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Sixten Harborg, MD @sixtenharborg.bsky.social · Dec 12

Lifestyle interventions will need to be a vital parameter of future studies assessing GLP1ra’s role in adjuvant BC care❗️

Sixten Harborg, MD @sixtenharborg.bsky.social · Dec 12

and future studies should carefully consider the ethics of inducing a weight loss with anti obesity medication in BC pts…if the drug is not efficacious it might leave pts with increased fat mass deposits when discontinuing the AOM.

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Sixten Harborg, MD @sixtenharborg.bsky.social · Dec 12

Still many questions to answer with regards to weight loss medications application in BC care❓

Prospective studies are needed❗️

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Sixten Harborg, MD @sixtenharborg.bsky.social · Dec 12

A great start to @sabcs.bsky.social day 3 with a session on survivorship.

Intriguing data on GLP-1ra’s in adjuvant BC care❗️ As suspected by many GLP1ra’s seems to be less effective in pts treated with ET…

Brilliantly discussed by @neil-iyengarmd.bsky.social 👏🏻

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Sixten Harborg, MD @sixtenharborg.bsky.social · Dec 12

Happy to be @sabcs.bsky.social and share the results from our study on the risk of CVD events and CVD mortality in BC patients with type 2 diabetes 🫀📈

Thankful to @graspcancer.bsky.social for awarding our poster with the GRASP Advocate Choice Award🏅

If you are at #SABCS24 and would like to chat⬇️

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Reposted by Sixten Harborg, MD

Antonio Giordano MD PhD @antgiordanomd.bsky.social · Dec 11

BWEL intervention with diet and weight loss is able to improve:
✅metabolic biomarkers
✅insulin resistance
✅ stress biomarkers
BWEL study presented by Dr. Jennifer Ligibel. Looking forward to future data with improved breast cancer outcomes. @dfcibreastonc.bsky.social #SABCS24

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Reposted by Sixten Harborg, MD

Eric Topol @erictopol.bsky.social · Nov 27

Lifestyle interventions to reduce cardiovascular and metabolic diseases, a new comprehensive review
nature.com/articles/s41...

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Reposted by Sixten Harborg, MD

Johanna Joyce @johannajoyce.bsky.social · Nov 23

Both #Cancer #Research starter packs are now completely full!

~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️

I hope you'll find these useful to build our community here

Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA

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