Lightnews — Scholar-powered news

Reposted by Sébastien Gauvrit

Beck Richardson @beckrichardson.bsky.social · 1d

Our new paper on valve disease in aged #zebrafish is out! onlinelibrary.wiley.com/doi/10.1111/... This has been a long running collaborative effort with contributions from lots of great people!

Aged Zebrafish as a Spontaneous Model of Cardiac Valvular Disease

Natural ageing in zebrafish results in spontaneous development of valvular degeneration in both the atrioventricular (AV) and bulboventricular (BV) valves. Aged zebrafish valves are larger and exhibi...

onlinelibrary.wiley.com

8 15

Reposted by Sébastien Gauvrit

Khoa @khoavuumn.bsky.social · 14h

Paper under review for 6 months at a journal

38 42 340

Reposted by Sébastien Gauvrit

Carmen Ruiz de Almodóvar @ruizdealmodovar.bsky.social · 12h

Interested in the heterogeneity of blood vessels in the CNS? Here we review the unique features of the spinal cord vasculature, its barrier properties and neurovascular interactions, highlighting unknown aspects and future research directions.
@CRC1366
@erc.europa.eu @immunosens.bsky.social

Neuron @cp-neuron.bsky.social · 14h

Neurovascular dynamics in the spinal cord from development to pathophysiology

Ruiz de Almodóvar et al. review the unique properties of spinal cord vasculature and its interactions with neural tissue across development, physiology, and disease, highlighting future directions to address open questions in neurovascular biology and translation.

dlvr.it

12 30

Reposted by Sébastien Gauvrit

Denis Duboule @denisduboule.bsky.social · 22h

Tomorrow wednesday October 15th at 11am, first seminar of @neilshubin.bsky.social , guest Professor @college-de-france.fr on ‘The history we share with fish’. Come, have a seat and enjoy learning where we come from. Free knowledge, no registration🤘

7 21

Reposted by Sébastien Gauvrit

Tony Firulli @tonyfirulli.bsky.social · 19h

Official publication day. Thanks to all the people who contributed to this. journals.biologists.com/dev/article/...

Hand1 gene replacement with Hand2 reveals overlap in function with unique occurrence of omphalocele and heart defects

Summary: Analysis of mice in which the protein coding of Hand1 is replaced with Hand2 coding reveals some functional redundancy, but most neonatal mutants present with omphalocele and cardiac morpholo...

journals.biologists.com

5 13

Reposted by Sébastien Gauvrit

Eric Topol @erictopol.bsky.social · 2d

When 2 life science discoveries converge: solving a ~3 decade mystery of extraordinary longevity and healthspan + an essential cell danger sensor
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...

A Long-Awaited Longevity Mystery Solved

Spotlighting an essential human biologic pathway targeted by drugs in clinical trials

erictopol.substack.com

3 40 150

Reposted by Sébastien Gauvrit

@NicoliLab @nicolilab.bsky.social · 4d

OMG 😱 a true game changer for biology! Menstruation is a natural miracle of tissue regeneration. Amazing biology to come!

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

1 6 15

Reposted by Sébastien Gauvrit

Ralf H. Adams @ralfhadams.bsky.social · 4d

A recent preprint (Yang et al., doi.org/10.1101/2025...) challenges an article from my lab published in 2024 (Koh et al. 2024, PMID: 39537918). We strongly dispute their claims (please see our comment on bioRXiv).

1/4

Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow

Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary ...

doi.org

1 8 16

Reposted by Sébastien Gauvrit

Jo Wolff @jowolff.bsky.social · 6d

This was not a sample of academics.

YouGov @yougov.co.uk · 6d

How many browsing tabs do you typically have open?*

1: 6%
2-5: 54%
6-10: 14%
11-20: 8%
21-30: 2%
More than 30: 3%

*across all windows, on desktop/laptop

yougov.co.uk/topics/techn...

21 34 200

Reposted by Sébastien Gauvrit

Oded Rechavi @odedrechavi.bsky.social · 7d

Fwd: Fwd: “I hope this email finds you well”

7 50 280

Reposted by Sébastien Gauvrit

marco-tarasco.bsky.social @marco-tarasco.bsky.social · 13d

📢 The #Danioheart atlas webpage has been updated.
In addition to the whole dataset (>34,000 zebrafish heart cells across 10 developmental stages) we now provide subclusters of each major cardiac cell population. #zebrafish #heart #scRNAseq
@stainierlab.bsky.social
www.mpi-hlr.de/danioheartat...

danioheartatlas

www.mpi-hlr.de

1 5

Reposted by Sébastien Gauvrit

W. Brent Derry @wbderry.bsky.social · 8d

Regulatory T-cells for the 2025 Nobel in Physiology or Medicine. www.nobelprize.org/prizes/medic...

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

2 6

Reposted by Sébastien Gauvrit

Journal of Cell Science @jcellsci.bsky.social · 11d

Mario Ledesma-Terrón, Diego Pérez-Dones, David Míguez and colleagues @cbm-csic-uam.bsky.social @ifimacuam.bsky.social present OSCAR, a framework to quantify 3D stacks with high cellular density.
journals.biologists.com/jcs/article-...

1 22 73

Reposted by Sébastien Gauvrit

Tilly Mommersteeg @tillymommersteeg.bsky.social · 13d

More new work from the lab! @idrm.ox.ac.uk @oxforddpag.bsky.social
Do all zebrafish regenerate their hearts equally? Also featuring the Mexican cavefish☺️
Thanks to all co-authors and especially the incredibly talented DPhil student Kostas Lekkos who drove the project. #zebrafish #heartregeneration

kostaslekkos.bsky.social @klekkos.bsky.social · 13d

Do zebrafish regenerate their hearts equally? In our new paper at the @tillymommersteeg.bsky.social lab we uncovered variations in the regenerative response of 7 wt zebrafish strains leading us to identify a critical role of oxidative phosphorylation in long-term heart regeneration.
rdcu.be/eI1v5

Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration

Nature Cardiovascular Research - Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in...

rdcu.be

2 8 14

Reposted by Sébastien Gauvrit

Christian Mosimann @chrmosimann.bsky.social · 14d

...and officially out now:
www.nature.com/articles/s41...
#devbio 🫀🎈

The pericardium forms as a distinct structure during heart formation - Nature Communications

The developing heart integrates several progenitor cell types. Here they show that the pericardium enveloping the heart develops among cells that form the mesothelium around inner organs and body cavities, distinct from the classic heart field.

www.nature.com

3 4 23

Reposted by Sébastien Gauvrit

Baptiste Lacoste @blacoste.bsky.social · 16d

Interested in assessing #BBB integrity at high resolution in 3D by electron tomography without spending $$$$$ on cryo-EM? I think we can help with this detailed method 😇 #cerebrovascular #microscopy #EM

Volumetric Analysis of the Blood–Brain Barrier After Ischemic Stroke by Electron Tomography in Mice

Objective Transmission electron microscopy (TEM) enables ultrastructural investigation of both organic and nonorganic samples. However, conventional TEM is limited by the acquisition of two-dimensio...

onlinelibrary.wiley.com

2 4 14

Reposted by Sébastien Gauvrit

Dr. Liz Haynes 🐟🔬 @drlizhaynes.bsky.social · 19d

Want to image the adult zebrafish brain? Here's a nifty design that I made with the help of a talented master's student, Corey Steinhauser.

Supporting files here!
morgridge.org/research/lab...

2 8 27

Reposted by Sébastien Gauvrit

Audrey Desgrange @audreydsg.bsky.social · 20d

Ventricle position can be remodeled after heart looping!
In a model of heterotaxy we uncovered a new asymmetric morphogenesis process during which the heart reorients its chambers.
So grateful to all the authors for their expertise and input during this long (but fun) ride 💪
Read more here ⬇️

Sigolène Meilhac @meilhacsigolene.bsky.social · 20d

New publication | Science Advances www.science.org/doi/10.1126/...

Plasticity of ventricle position after heart looping in heterotaxy with right isomerism

The left/right position of ventricles needs to be maintained after heart looping, an unexpected step affected in heterotaxy.

www.science.org

3 8 19

Reposted by Sébastien Gauvrit

Ian Scott @icscott.bsky.social · 21d

Two exciting Assistant Professor opportunities in Toronto! apply.interfolio.com/172703

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

3

Reposted by Sébastien Gauvrit

Ondine Cleaver @ondinecleaver.bsky.social · 29d

Join me next week, if you have interest in reviewing for the SDB's society ( @socdevbio.bsky.social 's) official journal, Developmental Biology (DB!) Always a fun and useful discussion.

Sign up today! forms.gle/4ZGYMErrA8YU...

3 6

Reposted by Sébastien Gauvrit

Rui Benedito @ruibenedito.bsky.social · Sep 12

We are looking for postdoctoral researchers to join us at the MPI for Molecular Biomedicine 👇 postdocprogram.mpg.de/all-postdoc-...

4 3

Reposted by Sébastien Gauvrit

Peng Huang @penghuang031.bsky.social · Sep 12

Thrilled to share our latest work from my fantastic postdoc fellow Dr. Emilio Méndez-Olivos: Pdgfab/Pdgfra-mediated chemoattraction guides the migration of sclerotome-derived fibroblast precursors in zebrafish, now published in @plosbiology.org! 1/8
dx.plos.org/10.1371/jour...

Pdgfab/Pdgfra-mediated chemoattraction guides the migration of sclerotome-derived fibroblast precursors in zebrafish

During vertebrate development, fibroblast precursors migrate from the sclerotome to specific tissues, but the mechanisms that guide these precursors remain unclear. This study shows that Pdgfab/Pdgfra...

dx.plos.org

3 8 26

Reposted by Sébastien Gauvrit

Daniel Durocher @durocher1.bsky.social · Aug 28

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

170 130

Reposted by Sébastien Gauvrit

Sara Nunes Vasconcelos, PhD she/her/hers🇨🇦🇧🇷 @saravasconcelos.bsky.social · Sep 9

Excited about this cutting-edge, cross-disciplinary conference I'm co-organizing at EMBL Heidelberg bringing together leaders in vascular biology, cardiac research, & bioengineering.
A stellar lineup of speakers w Keynotes:
James Martin & Alessandra Moretti
Opportunities for oral pres from abstracts

1 4 6

Reposted by Sébastien Gauvrit

Axel Montagne @axelmontagne.bsky.social · Aug 31

✨ Preorders are OPEN ✨

My amazing wife just finished her very first children’s book, and I couldn’t be prouder 💛

📚 Preorder until Sept 7
📦 Shipped w/ tracking
🔗 www.etsy.com/shop/ElodieWho

She’s poured her heart into this — every preorder, share, & boost means the world 🙌

www.etsy.com

1 4 4