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Ruth Amy Purcell @ruthamypurcell.bsky.social · May 12

Happy to have the latest @amywchung.bsky.social lab preprint online! 🦠 Here we demonstrated that systemic inflammation in solid tumor malignancy patients was associated with impaired SARS-CoV-2 neutralizing antibody functions while non-neutralizing functions remained robust (yay Fc functions!) 🦠

medRxivpreprint @medrxivpreprint.bsky.social · May 11

Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination https://www.medrxiv.org/content/10.1101/2025.05.09.25327344v1

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Reposted by Ruth Amy Purcell

IMAGE Lab @labphan.bsky.social · Apr 29

Happy #DayofImmunology! Congrats @ramadhenni.bsky.social & Alexandra Carey Hoppé it's out (finally!) @cp-cell.bsky.social! Incredibly grateful to co-leads @mlmunier.bsky.social, Vanessa Venturi & Tony Kelleher & all brilliant folks @garvaninstitute.bsky.social & Kirby Inst. for fantastic collab! 🧵

Macrophages direct location-dependent recall of B cell memory to vaccination

Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…

www.sciencedirect.com

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Reposted by Ruth Amy Purcell

Michelle Linterman @linterman.bsky.social · Apr 3

Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.

@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...

Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS

The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and...

doi.org

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Reposted by Ruth Amy Purcell

ViralVax Lab @viralvaxlab.bsky.social · Mar 11

1/ Hot off the press in @jimmunol.bsky.social. We investigated how same side (ipsilateral) vs alternate side (contralateral) prime-boost vaccination impacts germinal center (GC) dynamics & antibody responses against SARS-CoV-2 spike in mice.💉🦠#immunology #vaccines @thedohertyinst.bsky.social

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Ruth Amy Purcell @ruthamypurcell.bsky.social · Mar 1

Fantastic to have our study out describing the nuances of increased SARS-CoV-2 IgG4 following repeated mRNA vaccination 💉💉💉 @amywchung.bsky.social @kev-in-science.bsky.social @viralvaxlab.bsky.social
And great discussion started below!

Edward Nirenberg @enirenberg.bsky.social · Mar 1

#immunosky #IDsky #medsky 🧪

I know everyone missed thinking about IgG4, but we have a new study that finds some very interesting properties of anti-spike IgG4 elicited by mRNA vaccines

tl;dr- IgG4 seems to buffer inflammation but enhances the function of other antibodies when titers are lower

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Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant

Elevated SARS-CoV-2–specific IgG4 titers decrease ADCC but can increase ADCP when spike-specific antibody titers are low.

www.science.org

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