russellbiolab.bsky.social
@russellbiolab.bsky.social
Excited to share our new autophagy resource here, a dataset directly contrasting kinase regulators of bulk or organelle-specific autophagy. Look at the results for your gene/organelle of interest or get ideas for your own parallel screen. #autophagy #CRISPR #functionalgenomics
Losier, Russell et al. @uottawa.ca identify distinct kinase signaling pathways that differentially regulate bulk and selective #autophagy. Using kinome-wide #CRISPR screening, they reveal both shared and pathway-specific regulators rupress.org/jcb/article/...
August 27, 2025 at 1:59 PM
Really nice study!
This study from the labs of Wei Zou and Qiming Sun @ZJU_China uncovers Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/...

#mitophagy #lipophagy #xenophagy
April 9, 2025 at 3:41 AM