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roeldemaeyer.bsky.social
Roel De Maeyer
@roeldemaeyer.bsky.social
58 followers 70 following 3 posts
Immunology, inflammation and ageing
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Reposted by Roel De Maeyer
erictopol.bsky.social
Eric Topol @erictopol.bsky.social · 3d
Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...

Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...
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roeldemaeyer.bsky.social
Roel De Maeyer @roeldemaeyer.bsky.social · 3d
Such an overlooked area that needs much more attention. Major kudos and thanks to @emmaschambers.bsky.social for driving this work and here's to more exciting stuff in future!
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roeldemaeyer.bsky.social
Roel De Maeyer @roeldemaeyer.bsky.social · 3d
New paper alert #immunosky 🚨
What happens to our immune systems as we get older? What happens after the menopause? Turns out monocytes are actually quite important in their own right!

Check out our paper in Aging Cell now:
onlinelibrary.wiley.com/doi/10.1111/...
Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy
Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace...
onlinelibrary.wiley.com
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Reposted by Roel De Maeyer
emmaschambers.bsky.social
Dr Emma S Chambers @emmaschambers.bsky.social · Apr 2
If you have wondered how age, sex and even the menopause influences monocyte phenotype and function. Then our new preprint is for you www.biorxiv.org/content/10.1...
Age-associated inflammatory monocytes are increased in menopausal females and reversed by Hormone Replacement Therapy
Biological sex is a crucial, but poorly understood variable in age-related susceptibility to infections and chronic inflammation, inflammageing. Monocytes are important immune cells responsible for in...
www.biorxiv.org
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roeldemaeyer.bsky.social
Roel De Maeyer @roeldemaeyer.bsky.social · Jan 31
First Bluesky post, and it's a good one!
Check out a brand new review in @naturerevdrugdisc.bsky.social on targeting tissue immune interactions to improve age-related immunity:
www.nature.com/articles/s41...
Enhancing immunity during ageing by targeting interactions within the tissue environment - Nature Reviews Drug Discovery
Immune dysfunction increases with age owing to cellular senescence and low-grade inflammation, processes that drive each other during ageing. This Review discusses the potential of therapeutic approac...
www.nature.com
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