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Paul Sufka MD @psufka.bsky.social · 1d

AI discovers new cancer mechanism. Hopefully the first of many.

Paul Sufka MD @psufka.bsky.social · 1d

Reposted by Paul Sufka MD

ACR Journals @acr-journals.bsky.social · 2d

Management of SAPHO syndrome remains challenging. A systematic review found patients with SAPHO syndrome receiving JAK inhibitors had significant improvement in clinical symptoms and reduction in markers of inflammation. Time to response varied

ACR Open Rheumatology
doi.org/10.1002/acr2...
#Medsky

JAK Inhibitors for Treatment of SAPHO Syndrome: A Systematic Review of 72 Cases

Objective Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome usually involves bones, joints, and skin. Due to a lack of known pathogenesis and clinical trials, there is no stan...

doi.org

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Paul Sufka MD @psufka.bsky.social · 2d

Gigawatts-> tokens

Reposted by Paul Sufka MD

Eric Topol @erictopol.bsky.social · 6d

Reclaiming care of patients in the age of A.I.
"A.I. will not replace care, rather, it could help us rediscover it."
This week's @thelancet.com editorial
www.thelancet.com/journals/lan...

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Paul Sufka MD @psufka.bsky.social · 7d

Vera health offers CME already and is very good.

Paul Sufka MD @psufka.bsky.social · 8d

So much opportunty for medical app development with OpenAI's new Apps SDK. developers.openai.com/apps-sdk

Apps SDK

Learn how to use Apps SDK by OpenAI. Our framework to build apps for ChatGPT.

developers.openai.com

Paul Sufka MD @psufka.bsky.social · 10d

"general methods that leverage computation are ultimately the most effective, and by a large margin" —The Bitter Lesson, Rich Sutton www.incompleteideas.net/IncIdeas/Bit...

The Bitter Lesson

www.incompleteideas.net

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Paul Sufka MD @psufka.bsky.social · 11d

I can’t suggest using an AI scribe enough.
jamanetwork.com/journals/jam...

Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout

This quality improvement study examines whether ambient artificial intelligence (AI) scribes are associated with reductions in clinician administrative burden and burnout.

jamanetwork.com

Reposted by Paul Sufka MD

Eric Topol @erictopol.bsky.social · 14d

A.I. generated clinic notes from ambient out-patient visits helps clinicians in many ways, across 6 health systems jamanetwork.com/journals/jam...

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Reposted by Paul Sufka MD

Bob Wachter @bobwachter.bsky.social · 15d

My latest Substack: As OpenEvidence sprinted past UpToDate to become medicine's best AI-enabled point-of-care tool, I've been waiting for UTD's response. Now it's here, raising fascinating questions about which knowledge base should be our source of truth.
robertwachter.substack.com/p/medicines-...

Medicine’s AI Knowledge War Heats Up

The Battlegrounds May Surprise You

robertwachter.substack.com

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Paul Sufka MD @psufka.bsky.social · 15d

OpenEvidence or Vera Health >> UTD.

I find Grok and GPT5 really good at medical questions as well.

Reposted by Paul Sufka MD

Eric Topol @erictopol.bsky.social · 24d

Highlighting some of the many current pitfalls of A.I. in health care
@newyorker.com
@dhruvkhullar.bsky.social
www.newyorker.com/magazine/202...

If A.I. Can Diagnose Patients, What Are Doctors For?

Large language models are transforming medicine—but the technology comes with side effects.

www.newyorker.com

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Paul Sufka MD @psufka.bsky.social · 27d

Dr. Amanda Ombrello talking about autoinflammatory diseases

Paul Sufka MD @psufka.bsky.social · 27d

Always great to hear Dr. Marcela Ferrada speak about relapsing polychondtitis.

Paul Sufka MD @psufka.bsky.social · 27d

Slides and notes for my talk this afternoon: The Current State of AI in Rheumatology — Virginia Society of Rheumatology 2025 Annual Meeting paulsufka.com/ai/

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Paul Sufka MD @psufka.bsky.social · 29d

"LLMs have "dead reasoning zones" — areas in their weights where logic doesn't work. Humans have dead knowledge zones (things we don't know), but not dead reasoning zones. Asking questions outside the training distribution is almost like an adversarial attack on the model."

How I got the highest score on ARC-AGI again swapping Python for English

Using Multi-Agent Collaboration with Evolutionary Test-Time Compute

jeremyberman.substack.com

Reposted by Paul Sufka MD

ACR Journals @acr-journals.bsky.social · Sep 12

Retrospective review of patients with rheumatoid arthritis and BMI≥27 prescribed GLP-1RA (semaglutide or tirzepatide) showed improved disease activity & cardiovascular risk factors vs controls. Nearly one-third of GLP-1RA group discontinued during study period

ACROR
doi.org/10.1002/acr2...
#Medsky

Effect of Glucagon‐Like Peptide 1 Receptor Agonists on Patients With Rheumatoid Arthritis

Objective Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are approved for weight loss, diabetes, and cardiovascular risk reduction. Despite widespread use, GLP-1RAs have not been well studied ...

doi.org

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Paul Sufka MD @psufka.bsky.social · Sep 10

I started a Github repo for my AI Scribe Template github.com/psufka/AI-Sc...

Feel free to use/modify/share.

GitHub - psufka/AI-Scribe-Template: Template for rheumatology clinic visits

Template for rheumatology clinic visits. Contribute to psufka/AI-Scribe-Template development by creating an account on GitHub.

github.com

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Paul Sufka MD @psufka.bsky.social · Sep 9

Nobel Prize winner and Google DeepMind CEO Demis Hassabis: Future of AI, Simulating Reality, Physics and Video Games... youtu.be/-HzgcbRXUK8

Demis Hassabis: Future of AI, Simulating Reality, Physics and Video Games | Lex Fridman Podcast #475

YouTube video by Lex Fridman

youtu.be

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Paul Sufka MD @psufka.bsky.social · Sep 8

The Illusion of Thinking (Apple et al.)

Emergent statistical effect ≠ Thinking

ml-site.cdn-apple.com/papers/the-i...

Paul Sufka MD @psufka.bsky.social · Sep 8

Understanding why hallucinations happen gives ways to avoid them. I expect this will happen quickly (like everything else in AI).

Paul Sufka MD @psufka.bsky.social · Sep 5

I've wanted this feature for a while and hope all the models add this soon.

Paul Sufka MD @psufka.bsky.social · Sep 3

Soon (17 days):

https:// {3899, 13433, 1427, 1854, 1136, 14, 17527}

Paul Sufka MD @psufka.bsky.social · Sep 1

Have been thinking about doing something with #RheumJC.

Seems like something like Discord or Slack could be more useful for a journal club chat. (Or others, like Telegram, Whatsapp). Anyone have preferences?