PRIMED Consortium
@prsmethods.bsky.social
The NIH-funded Polygenic Risk Methods Development (PRIMED) Consortium. primedconsortium.org
Pinned
PRIMED Year in Review: Join us as we look back on some of what @prsmethods.bsky.social consortium members accomplished in 2025 to help improve genetic risk prediction in global populations 1/
The call for #DNADay26 essays is out! Open to students in grades 9-12 📝 🧬
Pro tip for genetics professionals: the contest is also often looking for judges...
Pro tip for genetics professionals: the contest is also often looking for judges...
The #DNADay26 Essay Contest is HERE! 🧬This year’s challenge: Analyze a genetic treatment or therapy developed or widely used in recent years. Teachers—help your students share their ideas with the world! Submit by March 4 👉 https://www.ashg.org/dna-day/ #ASHG
January 12, 2026 at 7:00 PM
The call for #DNADay26 essays is out! Open to students in grades 9-12 📝 🧬
Pro tip for genetics professionals: the contest is also often looking for judges...
Pro tip for genetics professionals: the contest is also often looking for judges...
PRIMED Year in Review: Join us as we look back on some of what @prsmethods.bsky.social consortium members accomplished in 2025 to help improve genetic risk prediction in global populations 1/
January 9, 2026 at 1:06 AM
PRIMED Year in Review: Join us as we look back on some of what @prsmethods.bsky.social consortium members accomplished in 2025 to help improve genetic risk prediction in global populations 1/
🧬🫀🌏 NEW data release from the OurHealth study of Cardiovascular Disease in South Asians now available on @anvilproject.org!
anvilproject.org/news/2025/11...
1/
anvilproject.org/news/2025/11...
1/
Release of The OurHealth Study on the AnVIL Platform - AnVIL Portal
anvilproject.org
December 3, 2025 at 8:41 PM
🧬🫀🌏 NEW data release from the OurHealth study of Cardiovascular Disease in South Asians now available on @anvilproject.org!
anvilproject.org/news/2025/11...
1/
anvilproject.org/news/2025/11...
1/
📢 New from the @prsmethods.bsky.social consortium, "Recommendations for responsible use of population descriptors in polygenic risk score development"! H/t to leads @johannalsmith.bsky.social and Quan Sun
www.nature.com/articles/s41...
in @natgenet.nature.com
www.nature.com/articles/s41...
in @natgenet.nature.com
Recommendations for responsible use of population descriptors in polygenic risk score development - Nature Genetics
In this Perspective, authors from the Polygenic Risk Methods Development (PRIMED) Consortium highlight the ethical and analytical impact of population descriptors in polygenic risk score development a...
www.nature.com
December 2, 2025 at 2:39 AM
📢 New from the @prsmethods.bsky.social consortium, "Recommendations for responsible use of population descriptors in polygenic risk score development"! H/t to leads @johannalsmith.bsky.social and Quan Sun
www.nature.com/articles/s41...
in @natgenet.nature.com
www.nature.com/articles/s41...
in @natgenet.nature.com
🎉 Congrats to Julie-Alexia Dias and thanks for the shout out to @prsmethods.bsky.social !
"Some of the most formative parts of my own training have come from working across groups and institutions...through my involvement in PRIMED (Polygenic Risk Methods Development)..."
"Some of the most formative parts of my own training have come from working across groups and institutions...through my involvement in PRIMED (Polygenic Risk Methods Development)..."
@ajhgnews.bsky.social sat with Julie-Alexia Dias, MSc, in the latest "Inside AJHG" to discuss her recently published paper, “Evaluating multi-ancestry genome-wide association methods: statistical power, population structure, and practical implications.”➡️ ashg.org/ajhg/inside-... #ASHG #humangenetics
November 7, 2025 at 12:49 AM
🎉 Congrats to Julie-Alexia Dias and thanks for the shout out to @prsmethods.bsky.social !
"Some of the most formative parts of my own training have come from working across groups and institutions...through my involvement in PRIMED (Polygenic Risk Methods Development)..."
"Some of the most formative parts of my own training have come from working across groups and institutions...through my involvement in PRIMED (Polygenic Risk Methods Development)..."
👀 🔖 ICYMI @prsmethods.bsky.social investigators report on incorporating social determinants of health into disease prediction in the NIH All of Us research program - www.medrxiv.org/content/10.1...
Quantifying Social Determinants of Health for Disease Prediction: A Multi-Level Approach Using Healthy People 2030 and All of Us Data
Despite the growing recognition that social determinants of health (SDoH) play a prominent role in shaping health outcomes, inconsistent measures across health systems and research studies - and the a...
www.medrxiv.org
October 29, 2025 at 10:15 PM
👀 🔖 ICYMI @prsmethods.bsky.social investigators report on incorporating social determinants of health into disease prediction in the NIH All of Us research program - www.medrxiv.org/content/10.1...
Attending #ASHG25? Learn how @prsmethods.bsky.social investigators are improving polygenic risk prediction in diverse populations by visiting these talks and posters docs.google.com/spreadsheets...
ASHG 2025 PRIMED Abstracts
docs.google.com
October 14, 2025 at 4:14 PM
Attending #ASHG25? Learn how @prsmethods.bsky.social investigators are improving polygenic risk prediction in diverse populations by visiting these talks and posters docs.google.com/spreadsheets...
👀🔖 Check out this new review by @prsmethods.bsky.social member Iftikhar Kullo, which explores the current state of the field, highlights key challenges, and outlines future directions for the use of PRSs to improve risk prediction and to advance personalized prevention in clinical care
New online! Clinical use of polygenic risk scores: current status, barriers and future directions
Clinical use of polygenic risk scores: current status, barriers and future directions
Nature Reviews Genetics, Published online: 10 October 2025; doi:10.1038/s41576-025-00900-8This article reviews the current state of implementation of polygenic risk scores in the clinical setting, highlights key challenges and outlines future directions for the use of such scores to improve disease risk prediction and to enable personalized prevention.
www.nature.com
October 10, 2025 at 6:00 PM
👀🔖 Check out this new review by @prsmethods.bsky.social member Iftikhar Kullo, which explores the current state of the field, highlights key challenges, and outlines future directions for the use of PRSs to improve risk prediction and to advance personalized prevention in clinical care
Reposted by PRIMED Consortium
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
www.medrxiv.org
September 2, 2025 at 11:08 PM
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
The PRIMED Consortium has a new handle: @prsmethods.bsky.social! Please tag us there when referencing our work or to share with us the latest in PRS methods development. We’re excited to keep connecting with you!
August 25, 2025 at 6:55 PM
The PRIMED Consortium has a new handle: @prsmethods.bsky.social! Please tag us there when referencing our work or to share with us the latest in PRS methods development. We’re excited to keep connecting with you!
👀 🔖 Congrats to @aliciahuerta.bsky.social @josepmercader.bsky.social and @prsdiversity.bsky.social co-authors and collaborators on this pre-print demonstrating that multi-ancestry PRSs improve T2D prediction across all ancestries
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Sharing a global effort to develop PRSs for T2D in multiple ancestries. www.medrxiv.org/content/10.1... funded by NHGRI @prsdiversity.bsky.social #D_PRISM
Collab with Maggie Ng, with Tian Ge, Alisa Manning, Marie Loh, Piper Below, Xueling Sim, led by star @aliciahuerta.bsky.social and Joohyun Kim
Collab with Maggie Ng, with Tian Ge, Alisa Manning, Marie Loh, Piper Below, Xueling Sim, led by star @aliciahuerta.bsky.social and Joohyun Kim
Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries
Background Polygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermin...
www.medrxiv.org
August 15, 2025 at 6:02 PM
👀 🔖 Congrats to @aliciahuerta.bsky.social @josepmercader.bsky.social and @prsdiversity.bsky.social co-authors and collaborators on this pre-print demonstrating that multi-ancestry PRSs improve T2D prediction across all ancestries
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
📣 Reminder that @anvilproject.org is calling all genomic researchers, data scientists, and cloud computing enthusiasts to register for the AnVIL Community Conference
In-person registration closes Aug 19: https:/bit.ly/anvil2025
In-person registration closes Aug 19: https:/bit.ly/anvil2025
⏳ Only 1 Week Left to Register for ACC2025! Register before August 19 to come to Nashville on Sep 3–5! bit.ly/anvil2025
🔵 Full (in-person): $75 🔵 Student (in-person): $25 🔵 Virtual: free
And don't forget to submit an abstract for a poster or talk by this Friday, August 15! bit.ly/acc2025-abst...
🔵 Full (in-person): $75 🔵 Student (in-person): $25 🔵 Virtual: free
And don't forget to submit an abstract for a poster or talk by this Friday, August 15! bit.ly/acc2025-abst...
AnVIL Community Conference 2025: Abstract Submission Form
Please use this form to submit an abstract (300 word limit) to the AnVIL Community Conference 2025 in Nashville, TN. The conference will take place from September 3-5, 2025. In-person attendance is…
bit.ly
August 14, 2025 at 8:46 PM
📣 Reminder that @anvilproject.org is calling all genomic researchers, data scientists, and cloud computing enthusiasts to register for the AnVIL Community Conference
In-person registration closes Aug 19: https:/bit.ly/anvil2025
In-person registration closes Aug 19: https:/bit.ly/anvil2025
Thanks to @elsihub.bsky.social for featuring "A data model for population descriptors in genomic research" from the NIH-funded @prsdiversity.bsky.social consortium in their "New Publications" section!
www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...
www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...
August 1, 2025 at 11:47 PM
Thanks to @elsihub.bsky.social for featuring "A data model for population descriptors in genomic research" from the NIH-funded @prsdiversity.bsky.social consortium in their "New Publications" section!
www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...
www.cell.com/ajhg/abstrac...
elsihub.org/news-and-eve...
Reposted by PRIMED Consortium
🚨 Registration is OPEN for #AnVILCommunity2025 Conference! Join us in Nashville, Sept 3-5 for talks, posters, & CoFest!
- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual
Don’t miss it!
- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual
Don’t miss it!
July 10, 2025 at 8:28 PM
🚨 Registration is OPEN for #AnVILCommunity2025 Conference! Join us in Nashville, Sept 3-5 for talks, posters, & CoFest!
- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual
Don’t miss it!
- Regular rate ($75): bit.ly/acc2025-register
- Student rate ($25): bit.ly/acc2025-register-student
- Virtual (free!): bit.ly/acc2025-register-virtual
Don’t miss it!
🎉 Out now in @ajhgnews.bsky.social: the @prsdiversity.bsky.social perspective on data sharing to improve genetic risk prediction in global populations 🧬🌎 🌍🌏
See also our thread on the pre-print - bsky.app/profile/prsd...
See also our thread on the pre-print - bsky.app/profile/prsd...
Data sharing is crucial to advancing health research. @ajhgnews.bsky.social's latest article provides policy recommendations to facilitate future use & sharing of heterogeneous data sources w/ a goal of improving polygenic risk prediction: www.cell.com/ajhg/abstrac... @prsdiversity.bsky.social
July 10, 2025 at 11:46 PM
🎉 Out now in @ajhgnews.bsky.social: the @prsdiversity.bsky.social perspective on data sharing to improve genetic risk prediction in global populations 🧬🌎 🌍🌏
See also our thread on the pre-print - bsky.app/profile/prsd...
See also our thread on the pre-print - bsky.app/profile/prsd...
ICYMI - see this recent work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social introducing a data model for population descriptors in genomic research 🎉 published in @ajhgnews.bsky.social
www.cell.com/ajhg/abstrac...
www.cell.com/ajhg/abstrac...
👀 🧬 Curious how to respectfully, robustly, and flexibly use population descriptors in genomic research, and align with @nationalacademies.org recommendations?
Check out this work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social, co-led by Alyna Khan and Stephanie Gogarten
Check out this work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social, co-led by Alyna Khan and Stephanie Gogarten
📣New from the PRIMED Consortium!
📄A data model for population descriptors in genomic research
📄A data model for population descriptors in genomic research
July 2, 2025 at 10:21 PM
ICYMI - see this recent work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social introducing a data model for population descriptors in genomic research 🎉 published in @ajhgnews.bsky.social
www.cell.com/ajhg/abstrac...
www.cell.com/ajhg/abstrac...
Happy #DNADay25 from the PRIMED Consortium @prsdiversity.bsky.social!
Genetic information can help improve risk prediction for a broad range of health outcomes.
Learn more:
🧬 Publications: primedconsortium.org/publications...
🧬 Research Highlights: primedconsortium.org/research/hig...
Genetic information can help improve risk prediction for a broad range of health outcomes.
Learn more:
🧬 Publications: primedconsortium.org/publications...
🧬 Research Highlights: primedconsortium.org/research/hig...
April 25, 2025 at 4:36 PM
Happy #DNADay25 from the PRIMED Consortium @prsdiversity.bsky.social!
Genetic information can help improve risk prediction for a broad range of health outcomes.
Learn more:
🧬 Publications: primedconsortium.org/publications...
🧬 Research Highlights: primedconsortium.org/research/hig...
Genetic information can help improve risk prediction for a broad range of health outcomes.
Learn more:
🧬 Publications: primedconsortium.org/publications...
🧬 Research Highlights: primedconsortium.org/research/hig...
Reposted by PRIMED Consortium
I wrote a thing.
I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach.
Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.
I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach.
Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.
Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics
https://go.nature.com/4jGqiUc
https://go.nature.com/4jGqiUc
Eugenics is on the rise again: human geneticists must take a stand
Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.
go.nature.com
April 24, 2025 at 2:25 PM
I wrote a thing.
I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach.
Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.
I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach.
Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.
👀 🔖 🧬 New @prsdiversity.bsky.social publication out in @ajhgnews.bsky.social, "Opportunities and challenges of local ancestry in genetic association analyses" 1/
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Opportunities and challenges of local ancestry in genetic association analyses
Recently, admixed populations make up an increasing percentage of the US and global populations, and the admixture is not uniform over space or time o…
www.sciencedirect.com
April 9, 2025 at 3:46 PM
👀 🔖 🧬 New @prsdiversity.bsky.social publication out in @ajhgnews.bsky.social, "Opportunities and challenges of local ancestry in genetic association analyses" 1/
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by PRIMED Consortium
I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...
April 3, 2025 at 2:48 PM
I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...
📣 Call for community feedback!
The @prsdiversity.bsky.social is using @anvilproject.org for shared data storage and collaborative analysis in the cloud - see a list of our workflows: primedconsortium.org/research/ana...
The @prsdiversity.bsky.social is using @anvilproject.org for shared data storage and collaborative analysis in the cloud - see a list of our workflows: primedconsortium.org/research/ana...
April 2, 2025 at 7:43 PM
📣 Call for community feedback!
The @prsdiversity.bsky.social is using @anvilproject.org for shared data storage and collaborative analysis in the cloud - see a list of our workflows: primedconsortium.org/research/ana...
The @prsdiversity.bsky.social is using @anvilproject.org for shared data storage and collaborative analysis in the cloud - see a list of our workflows: primedconsortium.org/research/ana...
Congratulations to @prsdiversity.bsky.social researchers @eimearekenny.bsky.social and @genandgenes.bsky.social, featured in @geneticssociety.bsky.social #WomensHistoryMonth
Honored to be featured in ASHG’s #WomensHistoryMonth celebration! Huge thanks to @GeneticsSociety & @sarahtishkoff.bsky.social for the recognition.
Grateful to stand alongside incredible women shaping human genetics & genomics! 💙 #ASHG #WomenInSTEM
www.ashg.org/publications...
Grateful to stand alongside incredible women shaping human genetics & genomics! 💙 #ASHG #WomenInSTEM
www.ashg.org/publications...
Celebrating Women's History Month: Trailblazing Women in Human Genetics and Genomics
ASHG President Sarah Tishkoff, PhD, celebrates women past and present who blaze trails in the human genetics and genomics field.
www.ashg.org
March 12, 2025 at 8:10 PM
Congratulations to @prsdiversity.bsky.social researchers @eimearekenny.bsky.social and @genandgenes.bsky.social, featured in @geneticssociety.bsky.social #WomensHistoryMonth
Reposted by PRIMED Consortium
📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!
March 4, 2025 at 12:27 PM
📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!
👀🔖 Curious how a research consortium manages sharing data to collaborate on improving genetic risk prediction in global populations? Check out this new preprint from the @prsdiversity.bsky.social data sharing working group! arxiv.org/abs/2502.09351 1/
Data Sharing in the PRIMED Consortium: Design, implementation, and recommendations for future policymaking
Sharing diverse genomic and other biomedical datasets is critical to advance scientific discoveries and their equitable translation to improve human health. However, data sharing remains challenging i...
arxiv.org
February 27, 2025 at 1:07 AM
👀🔖 Curious how a research consortium manages sharing data to collaborate on improving genetic risk prediction in global populations? Check out this new preprint from the @prsdiversity.bsky.social data sharing working group! arxiv.org/abs/2502.09351 1/
Reposted by PRIMED Consortium
So fantastic that NPR featured the unexplained troublingly high rates of heart disease among S Asian individuals, and our research efforts with the OurHealth Study to address these issues! www.npr.org/2025/02/11/n... @broadinstitute.org @prsdiversity.bsky.social
Researchers look to genetics to better understand heart disease in South Asians
People of South Asian descent are more likely to be affected by heart disease, but their risks often go unnoticed. Researchers are looking to genetics to learn more and prevent early deaths.
www.npr.org
February 11, 2025 at 2:12 PM
So fantastic that NPR featured the unexplained troublingly high rates of heart disease among S Asian individuals, and our research efforts with the OurHealth Study to address these issues! www.npr.org/2025/02/11/n... @broadinstitute.org @prsdiversity.bsky.social